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Zanaflex (Tizanidine)

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Zanaflex is a muscle relaxer used to treat stiff, rigid muscles and is particularly useful for spinal and nervous system conditions like multiple sclerosis and amyotrophic lateral sclerosis.

Other names for this medication:

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Also known as: Tizanidine


Generic Zanaflex is an agonist at (alpha) 2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, Generic Zanaflex has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of Generic Zanaflex are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. The imidazoline chemical structure of Generic Zanaflex is related to that of the anti-hypertensive drug clonidine and other (alpha) 2 -adrenergic agonists. Pharmacological studies in animals show similarities between the two compounds, but Generic Zanaflex was found to have one-tenth to one-fiftieth (1/50) of the potency of clonidine in lowering blood pressure. Zanaflex is also known as Tizanidine, Sirdalud. Generic name of Generic Zanaflex is Tizanidine-Oral. Brand name of Generic Zanaflex is Zanaflex.


You should take it by mouth. It usually is taken two or three times a day. If you want to achieve most effective results do not stop taking Generic Zanaflex suddenly.


If you overdose Generic Zanaflex and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zanaflex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Zanaflex if you are allergic to tizanidine, or if:

you also take the antidepressant fluvoxamine (Luvox); or you also take the antibiotic ciprofloxacin (Cipro).

To make sure Zanaflex is safe for you, tell your doctor if you have ever had:

liver disease; kidney disease; or low blood pressure; or high blood pressure.

It is not known whether Zanaflex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using tizanidine. Ask your doctor about any risk.

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Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial Infarction. We coexpressed the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) domains of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt)--namely NAhR and NArnt, respectively--which are known to form heterodimers and bind the cognate xenobiotic response element (XRE) sequence both in vitro and in vivo, as a positive control in the study of XRE-binding proteins in the MY1H system. The role of glutathione reductase in the cytotoxicity of chromium (VI) in isolated rat hepatocytes. This study suggests that susceptibility to malignant neoplasm is modified partly by fetal programming. An examination of covariates suggested that age effects were associated with age differences in mental health and affective responses rather than demographic or cognitive variables. A functional lateral shift of the mandible modulated the condylar cartilage extracellular matrix differently on each side of the condyle, which affected condylar morphology, growth, biomechanical properties, and even the susceptibility of the condylar cartilage to pathogenesis. The oval cell ductules are surrounded by a continuous basement membrane that is intermittently disrupted by processes of stellate cells that form direct cell-cell contact with the oval cells. Ultrastructural architecture of colonies of different morphologies produced by phenotypic switching of a clinical strain of Candida tropicalis and biofilm formation by variant phenotypes.

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Abstracts of the 5th Conference of the French-Speaking Clinical Epidemiology. Wanted: an effective public health response to hepatitis C virus in the United States. To further define the role played by two-step processing in mitochondrial biogenesis, we have now characterized the natural substrates of YMIP. Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination. Is it the time to reconsider the choice of valves for cardiac surgery: mechanical or bioprosthetic?.

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Photochemical inactivation of chikungunya virus in plasma and platelets using the Mirasol pathogen reduction technology system. Although correlative studies between MDCTA and coronary angiography (CA) show good agreement, MDCTA visualizes plaque burden and calcifications well before luminal dimensions are encroached. Forty patients with intra-oral cancer were given cobalt-60 teletherapy upon the primary lesion. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Low signals of radiating flow voids accompanied by high signals of slow blood flow or blood sinuses in the center part have high significance for the diagnosis of ASPS. The function of nsSNP-peptide was predicted using SIFT algorithm, and 2 nsSNPs were predicted to be damaged for protein function. As a result of this activity, the reader will (1) learn how children with SLI compare to their peers in producing third person pronouns, (2) learn the most common types of pronoun errors made by the children matched for mean length of utterance (MLU), and (3) evaluate how the findings relate to two current theories: one from typical language development and one from the area of SLI. Furthermore, this article will refresh the classification of trichomes in A. The impact of the ketone and amino moieties on guanine is revealed using their atomic-site-based inner-shell electronic properties and spectra.

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