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Xeloda (Capecitabine)
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Xeloda

Xeloda is a chemotherapy drug. It treats certain types of cancer like breast cancer, colon cancer, and rectal cancer. Xeloda belongs to the group of medicines called antineoplastics.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

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Hydrea, Trandate, Depakote, Zudena, Kamagra, Corvox, Birodogyl, Actical, Repaglinide, Zolran, Paracee, Pdone, Isoten,

Also known as: Capecitabine

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Xeloda dosage information

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls. coli that can enter, colonize urinary tract and cause infection are known as uropathogenic E. Readers were more sensitive to these demands when reading for recall than when reading for comprehension. However, nicotine also enhanced RVF processing and reduced negative affect, whereas it enhanced positive affect. Amino acids 114-135 of NSP4 are known to form the diarrhea-inducing region of this viral enterotoxin. Assessment of the quality of patient care is not possible without accurate, consistent documentation. The current article outlines the literature on substance abuse among Vietnamese, Cambodians and Laotians in the U.S., and makes tentative recommendations for assessment, treatment and future research. The data of the present study provide a basis for future studies to elucidate the molecular mechanism of follicular atresia and regulation of apoptotic cell death in ovarian follicles. Tumors became detectable between days 10-30, with approximately a 3 log increase in the luminescence signal by day 75. This study examined the effect of sense modality (auditory/visual) on emotional dampening (reduced responsiveness to emotions with elevation in blood pressure).

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In literature, most publications have been focused on the effects of the second generation antipsychotics (SGA) on glucose metabolism. We then provide an overview of the development of lipid activity probes to label and identify proteins that bind to a particular lipid from complex biological samples. Reversal was not undertaken in one due to subsequent development of liver metastases. Moreover, the total surface area of the nanoparticles in solution can be known with high precision and thus can be directly used for the kinetic analysis. New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices: A Survey of Practicing Ob-Gyns. Regression analyses were used to investigate the relationship between the level of productivity costs and the type of depressive disorder, the type of treatment and study characteristics such as time horizon used and productivity cost valuation method. We have used mouse entorhinohippocampal slice cultures to assess regeneration of entorhinal fibers after mechanical lesions in vitro.

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Although further research is needed to characterize the CV effects of exercise, particularly in elderly women and the oldest old population, aerobic endurance exercise should be advocated in the healthy elderly. Due to the availability of efficacious drugs for many years, research focused on blackhead was minimal. The mix of semiochemicals of opposite activity in each extract or fraction could explain the stimulatory-, inhibitory-, or sometimes neutral activity. The Hemagglutination Inhibition (HI) Antibody Test for the Determination Of Immunity to Rubella. These amino acid changes result in significant alterations of important channel properties. Our aim was to confirm this character of cationic materials and investigate its possible mechanism. Our study suggests that only annual mechanical clearing coupled with sheep and goats grazing can significantly reduce bramble cover. To improve scaffold functionality, increasing interest is being focused on in vitro and in vivo research in order to obtain the optimal scaffold design for a specific application.

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The results were statistically analysed with independent T test. We believe this pathology may in fact be fairly common, but that video-EEG monitoring is essential for diagnosis. To investigate the expression of MGST1 in primary tumors, solid metastases and metastatic effusions in advanced-stage serous ovarian carcinoma (OC) and analyze the association with clinicopathologic parameters, including chemotherapy resistance and survival. Generally, females and patients with bilateral lesions scored higher in all DHI subscales. The diameter of the pampiniform plexus and prostatic venous plexus was measured using scrotal and transperineal ultrasonography, respectively. Furthermore, SAHA and cisplatin combination treatment significantly decreased tumor metastasis and nanog expression, in vivo. Most patients with multiple myeloma (MM) are considered to be incurable, and relapse owing to minimal residual disease (MRD) is the main cause of death among these patients. It does, however, provide a therapeutic option for patients for whom transplantation is contraindicated. For 70 years it has been suspected that not all microfissures in histological bone sections are artifacts, but that some are provoked in vivo through repetitive stress. Tick-borne encephalitis virus NS1 glycoprotein during acute and persistent infection of cells.

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Infection, contagion and causality in Colonial Britain: the 1889-90 influenza pandemic and the British Medical Journal. Additionally, no indications of vertebral fractures or any other occurrences due to external factors are present. Somatostatin, when applied as intravenous bolus injection, controls acute bleeding very efficiently and quickly. Synthesized PGTAVFK and IKAFKEATKVDKVVVLWTA soy peptides were tested against Pseudomonas aeruginosa and Listeria monocytogenes using a microdilution assay. To investigate the significance of aquaporin-1(AQP-1) and aquaporin-3(AQP-3) in the development of colorectal carcinoma. Assays were performed after 5- or 24-h incubations to further enhance the sensitivity of detection of toxicity. The Society for Immunotherapy of Cancer (SITC) Biomarkers Task Force addressed the state of the art and made a series of recommendations for the field, which is summarized here. The question of whether a 4 or 9 week premating treatment period is more suitable in studies for effects on fertility and early embryonic development, and the extent to which the screening of sperm parameters may contribute to the detection of effects, has been under discussion since the ICH guideline changed in 1994/1995. Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it?. weihenstephanensis, and that intermediate forms between the two species exist.

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This article describes how the components of The NLN Jeffries Framework can help to guide simulation design for nurse educator preparation. A major player in this process is GrB (granzyme B), which triggers apoptosis in both caspase-dependent and caspase-independent pathways. In this study, a self-assembled cationic nanomicelles based on polyethyleneimine-stearic acid (PSA) copolymer were developed to delivery HIV-1 gag encoding mRNA to dendritic cells and BALB/c mice. However, beyond this kind of damage iron is known to catalyze the generation of hydroxyl radicals from superoxide anions and to increase oxidative stress which, in turn, increases free iron concentration. HPLC fingerprint analysis of flavonoids of phyllanthi fructus from different habitats.

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Retrospective review was performed on 50 sets of MR images of 25 patients who underwent both 3-T and 1.5-T brain imaging with a dedicated epilepsy protocol, including fast spin-echo T2-weighted, coronal FLAIR, coronal fast multiplanar inversion recovery, and 3D spoiled gradient-recalled echo pulse sequences. Although the majority of the studies identified changes in one or more outcome measurements across exercise modalities, the majority were non-significant, possibly due to Type II errors. A modification of the collar-and-cuff sling to elevate the hand. Reference ranges for hemoglobin variants by HPLC in African Americans. Because elevated levels of enkephalin in certain areas of the central nervous system may be necessary for antipsychotic activity, we have examined the effect of clozapine on certain receptors and mRNA transcripts involved in the opioid peptidergic system. In higher eukaryotes, the mechanisms used involve controlled modifications to both local and global DNA environments, principally through changes in chromatin structure as well as cis-element-driven mechanisms. FAU, which encodes a ubiquitin-like protein (termed FUBI) with ribosomal protein S30 as a carboxy-terminal extension, has recently been identified as a pro-apoptotic regulatory gene. Collateral sensitivity between aminoglycosides and beta-lactam antibiotics depends on active proton pumps. Effect of dinitrosyl iron complexes with glutathione on hemorrhagic shock followed by saline treatment. Patient 2 (46 XX), phenotypically female, presented for hypertension and amenorrhea.

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A new class of aromatic metamorphosis in which benzofurans are converted into diverse six-membered oxaheterocycles has been developed. Listening Effort: How the Cognitive Consequences of Acoustic Challenge Are Reflected in Brain and Behavior. In this case, the thermoregulatory center of the hypothalamus might be symptomatic zone of temporal lobe epilepsy. Transition from narrow to wide QRS tachycardia: what is the mechanism?. At low concentrations that do not cause mitotic arrest, PTX did not significantly inhibit proliferation of these cells. The expression of c-myc protein showed a similar distribution pattern to that of TERT, suggesting that c-myc protein might induce telomerase activity in ameloblastomas.

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Trocara virus: a newly recognized Alphavirus (Togaviridae) isolated from mosquitoes in the Amazon Basin. In our present study, we analyzed for the first time ZFN-activated gene repair of an USH gene. Endogenous CK2 is associated with JAK2 and JAK1 and phosphorylates JAK2 in vitro. We aimed to validate this approach and investigate the utility of a D2-40 antibody. Here, we focus attention on the Tetramorium fauna of India, a region of high biodiversity value and interest for conservation. Results in EAP rats were compared with data from rats immunized with kidney homogenate, BSA, and CFA, as well as nontreated rats. The inclusion criteria for the review were that the documents were original quantitative research and published in English.

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Cats and Toxoplasma gondii: A systematic review and meta-analysis in Iran. Socioeconomic variables, gender, heredity, capillary glucose control and local factors (prosthesis, dry mouth sensation) were analyzed in 196 diabetic and non-diabetic patients enrolled in HIPERDIA, at 41 Health units of Natal, Brazil. The aim of this study was to determine the long-term incidence of disc degeneration adjacent to an anterior interbody fusion and to determine whether this was influenced by the length of the fusion. A high index of suspicion is necessary in order to diagnose this rare what is the drug minocin used to treat condition. To investigate the usefulness of the NSC-60 questionnaire as a screening tool for CSE among painters and to investigate the course of the number of CSE cases over the years as a potential consequence of improved prevention and control.

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PRO2 predicted the short-term outcomes of remission induction treatment earlier than FC possibly because of the wide within-day variability of FC in active UC. Cardiovascular risk reduction: a randomized trial of two health promotion strategies for lowering risk in a community with low socioeconomic status. Changes in open phases of maintenance studies to reduce study enrichment, in study endpoints, and in statistical approaches to analysis of data are warranted. Special attention has been given to verbal memory deficits in schizophrenia because they are apparent in healthy biological relatives of affected individuals, indicating a link to genetic risk for the disorder. Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine. Pd NPs of different sizes and densities, which can modulate the photocatalytic activity of the as-prepared WS2/PdNPs, were effectively structured on the basal plane of 2H-WS2 nanosheets via a sonic wave-assisted nucleation method without any reductants at room temperature. aeruginosa in an immunogenically silent manner both in vitro and in vivo Treatment with CATH-2-killed P. The reflux was unilateral in 22 and bilateral in 9 (40 refluxing units).

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Design and validation of an annular shear cell depakote dose adjustment based on levels for pharmaceutical powder testing. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. The oxidative stress in allelopathy: Participation of prenyllipid antioxidants in the response to juglone in Chlamydomonas reinhardtii. Possible changes in expression of chemotaxin LECT2 mRNA in mouse liver after concanavalin A-induced hepatic injury.

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A cross-sectional survey on prevalence and risk factors for persistent postsurgical pain 1 year after total hip and knee replacement. Pain and the impossibility of sleeping due to noise and having tubes in the nose and mouth were considered the most important physical stressors. Cytotoxic strains of Pseudomonas aeruginosa can damage the intact corneal surface in vitro. To address this problem, a model of equilibrium self-assembly is formulated in which dynamically associating species organize into hierarchical structures that preserve their shape at each stage of assembly. The loop recorder enables documentation of the rhythm during a subsequent syncope. Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2. A proteolysis network was also built up, of which the CAPN2 centered subnetwork, including SPTBN1, ATP5B, and VIM, was more active in highly metastatic HCC cell line. A ten-port valve simultaneously permits equilibration of one analytical column while the other is used for sample analysis. TNF, immunity and inflammatory disease: lessons of the past decade.

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