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Sustiva

Sustiva is an antiretroviral medicine that fights human immunodeficiency virus (HIV-1) infection by reducing the amount of the virus in blood. It is used by adults, adolescents and children 3 months of age and older and weighing at least 3.5 kg.

Other names for this medication:
Cytocom, Duovir, Efavir, Efavirenz, Efcure, Efferven, Emduo, Estiva, Evirenz, Lamivir, Lazid, Odivir, Retrodel, Revenz, Tenola, Trioday, Trustiva, Viraday, Viranz, Virocmb, Virolis, Vonavir, Zidolam

Similar Products:
Noroxin, Danocrine, Clozaril, Lamictal, Levothroid, Keflex, Acticin, Efavirenz, Rivol, Citroj, Montair, Norvin, Silam, Nexpro, Lamivir, Bakton,

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Also known as: Efavirenz

Description

Sustiva is used to treat HIV infection in combination with other anti-HIV medications. If Sustiva is the only drug you take to treat HIV infection, it may stop working. Sustiva is an oral medication that is used for the treatment of infections with the human immunodeficiency virus (HIV). It is similar to nevirapine (Viramune) and delavirdine (Rescriptor). Sustiva is also known as Efavirenz, Stocrin. Sustiva is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), and lamivudine (Epivir). During infection with HIV, the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to form this new DNA. Sustiva directly inhibits the activity of reverse transcriptase and blocks the production of DNA and new viruses. Unlike zidovudine, efavirenz does not need to be converted to an active form. Sustiva does not kill existing HIV virus and it is not a cure for HIV.

Dosage

Usual Adult Dose for HIV Infection:

600 mg orally once a day Comments: -This drug should be used with a protease inhibitor and/or NRTIs. Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure:

US CDC recommendations: 600 mg orally once a day Duration of therapy: 28 days Comments: -This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or tenofovir); recommended as the preferred NNRTI-based regimen for nonoccupational postexposure prophylaxis of HIV infection. -Prophylaxis should be started as soon as possible, within 72 hours of exposure. -Not approved by US FDA.

Usual Adult Dose for Occupational Exposure:

US Public Health Service working group recommendations: 600 mg orally once a day Duration of therapy: 28 days, if tolerated Comments: -An alternative antiretroviral agent for use as HIV postexposure prophylaxis only with expert consultation -Prophylaxis should be started as soon as possible, preferably within hours after exposure. -The optimal duration of prophylaxis is unknown and may differ based on institution protocol. -The most current therapeutic guidelines should be consulted for more information. -Not approved by US FDA.

Usual Pediatric Dose for HIV Infection:

3 months or older: 3.5 to less than 5 kg: 100 mg orally once a day 5 to less than 7.5 kg: 150 mg orally once a day 7.5 to less than 15 kg: 200 mg orally once a day 15 to less than 20 kg: 250 mg orally once a day 20 to less than 25 kg: 300 mg orally once a day 25 to less than 32.5 kg: 350 mg orally once a day 32.5 to less than 40 kg: 400 mg orally once a day 40 kg or more: 600 mg orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Detailed Sustiva dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sustiva are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Sustiva if you are allergic to Sustiva components. Do not take Sustiva if you are pregnant, planning to become pregnant, or are breast-feeding. It is unknown if Sustiva is excreted in breast milk. Avoid breast-feeding because breast milk can transmit HIV. Be careful with Sustiva if you have mental disorders, liver disease (such as hepatitis). Avoid machine driving. Limit alcohol intake, as it may intensify drug side effects. It can be dangerous to stop Sustiva taking suddenly.

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Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance. Diabetes is not a single disease but a group of diseases characterised by hyperglycaemia. The originally prescribed standard conformal four-field box technique, which includes the use of lateral ordinary wedge beams, was compared to a modified conformal treatment using customized lateral PWBs. Elevated levels of palmitic, palmitoleic and arachidonic acids, along with a low level of linoleic acid, were observed in membrane phospholipids of tumors with poor histoprognostic grade. Centrobin/Nip2 expression in vivo suggests its involvement in cell proliferation. Twenty-seven patients with immunobullous disease treated with azathioprine were enrolled during a 2-year period. Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT.

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Minimal invasive therapy of aneurysms of the superficial femoral artery and the popliteal artery. In this Practice Point commentary, we discuss the findings and limitations of a randomized, placebo-controlled trial conducted by Lewis and colleagues that examined the efficacy of rosiglitazone for the treatment of patients with mild-to-moderately active ulcerative colitis. Given the difference between our results and that reported in inter-order comparisons of brain size in birds, further research is required into other avian orders to assess how brain size and behavior might be related within orders as well as between them. However, other aspects (blood pressure, anemia, nutrition, inflammation, mineral metabolism and prevention of cardiovascular events) and, in particular, residual renal function must be taken into account. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Though fungi from mangrove ecosystem have been reported for production of several lignocellulolytic enzymes, they remain unexplored for their SCO producing ability. Specimens were analyzed to verify the presence of damaged vessels in and outside the ablation area. The amount of removed iron from these patients was more than that from gastrectomized patients.

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We used a comprehensive and clinically relevant assessment method to evaluate the hypothesis that a computerised tutorial more effectively increases knowledge acquisition than a facilitated case discussion. Comparison of DNA content, S-phase fraction, and survival between medullary and ductal carcinoma of the breast. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation. The high risk human papillomaviruses and oral cancer: evidence for and against a causal relationship.

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