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Prometrium (Progesterone)

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Prometrium is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy. Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause.

Other names for this medication:
Conest, Dubagest, Durbagest, Evagest, Forgest, Gemgest, Gestovin, Hilgestrone, Isogest, Macgest, Miprogen, Namgem, Naturone, Nidagen, Npton, Orgasest, Ornapro, Pgfast, Powergest, Pregcitil, Pregzed, Progminat, Promyzz, Rigest, Rimgest, Sperogest, Strone, Susten, Utrovin, Vageston, Wongest, Zesty, Zygogest

Similar Products:
Biaxin, Zanaflex, Strattera, Aldactone, Lodine, Glucotrol, Avodart, Addyi, Xalatan, Diamin, Metazole, Scalix, Budefex, Kemadrin,

Also known as: Progesterone


Progesterone is used to help prevent changes in the uterus (womb) in women who are taking conjugated estrogens after menopause. It is also used to properly regulate the menstrual cycle and treat unusual stopping of menstrual periods (amenorrhea) in women who are still menstruating.

This medicine is available only with your doctor's prescription.


It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine comes with a patient information leaflet. Read and follow the instructions in the leaflet carefully. Ask your doctor if you have any questions.

For women who use this medicine after menopause, it will be given together with an estrogen medicine. Carefully follow the schedule your doctor gives you for both medicines.

If you have trouble swallowing this medicine, take it with a glass of water while standing up. Talk to your doctor or pharmacist if this does not help.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For prevention of thickening of the lining of the uterus (endometrial hyperplasia): Adults—200 milligrams (mg) per day, taken as a single dose at bedtime, for 12 continuous days per 28-day menstrual cycle. Children—Use is not recommended. For treatment of unusual stopping of menstrual period (amenorrhea): Adults—400 milligrams (mg) per day, taken as a single dose at bedtime, for 10 days. Children—Use is not recommended.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Prometrium dosage information

Side effects

The most common side effects associated with Prometrium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of progesterone is not indicated in children. Safety and efficacy have not been established.

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