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Prograf (Tacrolimus)

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Prograf works on the immune system to prevent rejection of an organ transplant and is usually taken in combination with other anti-rejection medications. Swallow the capsules and tablets whole. Don’t cut, crush, or chew them.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus


Prograf (tacrolimus) weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Prograf is a prescription medicine and is used together with other medicines to prevent your body from rejecting a heart, liver, lung, or kidney transplant.

Prograf is supplied as oral capsules, granules for oral suspension, and as an injection for intravenous use.

Prograf capsules and oral granules are immediate-release medicines and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.


Take Prograf exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may receive an injection of Prograf shortly after your transplant. The injection is given until you are ready to take the pill form of tacrolimus.

Take Prograf at the same time each day, with a full glass of water.

Swallow the capsule whole and do not crush, chew, break, or open it.

Mix Prograf oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water.

You may take Prograf with or without food, but take it the same way each time.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need frequent medical tests, and your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Detailed Prograf dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Prograf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Analysis of the quality of reporting of randomized controlled trials in acute and chronic myeloid leukemia, and myelodysplastic syndromes as governed by the CONSORT statement. It focuses on the early years of bicycle and automobile use, using municipal council minutes, local newspapers, and satirical magazines as sources. One-half of both vaccinated and nonvaccinated groups of birds were challenged at 35 and 42 days of age with a recent IBV Ark field isolate. The instrument was self-administered by patients after an interval of 7 days. Becker muscular dystrophy is milder, often presenting after age 5, with ambulation frequently preserved past 20 years and sometimes into late decades. RNA in the spotlight: the dawn of RNA therapeutics in the treatment of human disease.

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Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. Specific stains were used to detect the presence of micro-organisms and associated carbohydrate, a major constituent of the biofilm matrix. The mineral coating of Dyerophytum indicum Kuntze (Plumbaginaceae) was analyzed by isotope ratio mass spectrometry, X-ray diffraction, thermogravimetric and differential thermal analysis, and scanning electron microscopy/energy-dispersive X-ray spectroscopy methods. We have successfully established three continuously growing cell lines from tissue obtained from a metastatic human carcinoid of the terminal ileum (midgut carcinoid): P-STS was derived from the primary equate motrin pill tumor, L-STS from a lymph node metastasis and H-STS from a hepatic metastasis. For two genes--EIF1AX/Y and RPS4X/Y--transposition to autosomes occurred independently in three distinct lineages. Synchronization, re-entry, and failure of spiral waves in a two-layer discrete excitable system. MMP modulatory factors, such as TIMPs and uPA, did not change after the 4-MU was administered. Here we show that the same conclusion does not apply to the visual recognition impairment produced by aspiration lesions of perirhinal cortex inasmuch as equally severe impairment was found after excitotoxic lesions of this cortex. Transesophageal echocardiography showed the lack of one leaflet of the prosthesis and regurgitation.

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