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Plavix (Clopidogrel)
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Plavix

Plavix is an antiplatelet medication. It works by preventing platelets from sticking together, thereby decreasing the formation of harmful blood clots. This lowers the chance of heart attack or stroke.

Other names for this medication:
Aclotil, Adplatt, Antiban, Anticog, Aplatin, Clavix, Clodrel, Clopact, Clopicard, Clopicure, Clopidogrel, Clopigrel, Clopilet, Clopiriv, Clopivas, Cloplat, Clopod, Cloprez, Clospir, Closprez, Clotnil, Grelet, Kabitrol, Livigrel, Myogrel, Noklot, Oprin, Platfree, Rozanex, Starclop, Stromix, Synplatt, Themigril, Thrombosprin, Torplatt

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Risperdal, Cytoxan, Plavix, Keflex, Valtrex, Sporanox, Corixil, Atenolol, Estiva, Somavent, Imipam,

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Also known as: Clopidogrel

Description

Plavix (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

Plavix is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.

Dosage

Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Plavix dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Plavix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Plavix if you are allergic to Plavix components. Do not take Plavix if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Plavix if you suffer from or have a history of stroke, stomach ulcer or ulcerative colitis; liver or kidney disease, hemophilia. Be careful with Plavix if you are taking such medicines as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs such as naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ibuprofen (Motrin, Advil), (Toradol), ketoprofen (Orudis), nabumetone (Relafen), piroxicam (Feldene), ketorolac mefenamic acid (Ponstel), meloxicam (Mobic) and the others), phenytoin (such as Dilantin); torsemide (such as Demadex); medication used to prevent blood clots (alteplase (such as Activase), anistreplase (such as Eminase), dipyridamole (such as Persantine), streptokinase (such as Kabikinase, Streptase), ticlopidine (Ticlid) and urokinase (such as Abbokinase); fluvastatin (such as Lescol); a blood thinner (warfarin (such as Coumadin), heparin, ardeparin (such as Normiflo), dalteparin (such as Fragmin), danaparoid (such as Orgaran), enoxaparin (such as Lovenox), or tinzaparin (such as Innohep); tamoxifen (such as Nolvadex); tolbutamide (such as Orinase). It is not recommended to do sport while taking Plavix because it can cause bleeding or bruising injury. If you are going to have a surgery you should stop taking Plavix for 5 days before the surgery. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Plavix suddenly.

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Experimental and theoretical study of the oxidation of ventilation air methane over Fe2O3 and CuO. Necessary for these outcomes is the liberal use of both rescue PCI and in-hospital revascularisation. Despite a large number studies, there remains no high-quality evidence that hypothermia is beneficial in the treatment of people with TBI. Triplets: outcomes of expectant management versus multifetal reduction for 127 pregnancies. Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer. Evaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations. The applicability and usefulness of the new approach are demonstrated in the context of the recently measured multidimensional infrared spectra of dimanganese decacarbonyl. Further training for all involved professional groups must be improved. This system will provide a distributed architecture for both scheduling assistance and task guidance, as well as intelligent, automatic replanning on the levels of both the schedule and individual tasks. Cut flow and bypass flow measurements were, respectively, taken before and after completion of anastomoses.

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Wound healing is impaired in diabetes mellitus, but the mechanisms involved in this process are virtually unknown. Electrically driven (1 Hz) ventricular trabeculae from explanted failing human myocardium were indirectly examined for the localization of the alpha1-adrenoceptor population and the beta-adrenoceptor population in relation to sympathetic nerve endings. Gold nanoparticles have greatly improved the traditional treatment due to their unique properties. Metabolically engineered microorganisms may have tremendous potential in removing toxic compounds from nature. A systematic review was carried out following PRISMA recommendations including studies searched in Pubmed-Medline, Embase and Cochrane databases. Ascaris lumbricoides infection may, therefore, cause high-grade fever after cardiac surgery.

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D-Enantiomers of most protein L-amino acids were detected in all physiological samples of animals. Online public reactions to fMRI communication with patients with disorders of consciousness: Quality of life, end-of-life decision making, and concerns with misdiagnosis. The combination of a well-developed tapetum lucidum, an unpigmented pigment epithelium, well-developed rods, and a high number of rods converging on only few ganglion cells is obviously an adaptation to an extreme light sensitivity, enabling the animals hydroxyurea pediatric dosing to make use of the little light available in the deep sea. In this study we examined the effect of Slc2a8 deficiency on mouse gamete, preimplantation embryo, and implantation phenotype, as well as postnatal growth and physiology. Laboratory findings showed an erythrocyte sedimentation rate (92 in the first hour), positive histocompatibility antigen HLA-B27 and an increased level of acute phase reactants. Effects of a ketogenic diet on hippocampal plasticity in freely moving juvenile rats. The order of collection of the specimens was rotated every 50 patients. To compare five strategies for the diagnosis and treatment of cervical squamous intraepithelial lesions (SILs), including those that incorporate colposcopy and a new technology, fluorescence spectroscopy. The direct approach to detection and taxonomic placement of endophytic fungi within host tissue without the need for conventional in vitro culturing is discussed.

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Our data indicate that muscle cells in lean individuals and in those with severe obesity have innate differences in management of protein degradation, which may explain their metabolic differences. These findings will provide valuable information for further functional verification of miRNAs and their targets in radish taproot development. Accordingly, growing interest exists in defining the pathologic mechanisms involved. Genomic target DNA is subsequently visualized in labeled cells by fluorescent in situ hybridization using biotin-labeled chromosome-specific DNA probes. A logistic regression model was constructed, compared with the LACE and validated in a separate population. Fear conditioning can contribute to behavioral changes observed in a repeated stress model. In addition, we found two male-biased odorant receptors that did not group with previously described pheromone receptors. The results showed that benznidazole solubility increased up to 18.38 mg/ml in the optimised co-solvent system.

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Mutations in this cluster do not affect the binding of cytochrome c as the KM remains largely unchanged. This, together with other neuropathological phenotypes, including aberrant vacuolisation and lipid accumulation, indicates that deficiency in ATF2 leads to neurodegeneration of subsets of somatic and visceral motoneurons of the brainstem. Role of reproductive surgery in the era of assisted reproductive technology. Thus, the SAVE provides measurement of the stressor criterion associated with posttraumatic stress disorder, and allows quantification of severity of violence exposure by setting. The on-line nature of this microscopy system offers an opportunity to monitor the dynamics of the cell damage process and to gain insights into the mechanism governing photolytic cell injury processes. canimorsus septic shock in a post-splenectomy patient and review the epidemiology of OPSI, the role of the spleen in protecting the body from infection, and the potential role of early goal-directed therapy in the resuscitation of patients with OPSI. More specifically, we describe and give examples of the model of asking questions developed by Karl Tomm (1988) through its application in Family Focused Grief Therapy (FFGT), a preventive intervention delivered to high-risk families during palliative care and bereavement.

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Epidural analgesia (EA) has been more investigated during the perioperative sumycin period than in the intensive care unit (ICU) setting. Output from accelerometers can differentiate physical activity intensity in children with an acquired brain injury. As examined by electrophoretic mobility shift analyses, the HMGA protein and the proteins containing an HMG domain (HMGB proteins and SSRP1) bind specifically to purified maize mononucleosomes that contain a histone octamer and approximately 165 bp of DNA. To pursue further this possibility we measured the generation of immunoreactive endomorphin-2 (E2-IR) in adult rat isolated L4,5 dorsal root ganglia. Length constraints are also included in the integrated minimization procedure. Our system provides a new tool allowing for highly sensitive and specific detection and genetic analysis of CTCs in HCC patients. A postal questionnaire was sent to all private practice office-based physicians in the Nord-Pas de Calais region. Effector-target conjugation between different cell populations of human NK cells and K562 tumor cells has been studied from binding isotherms obtained from data of effector (alpha) and target (beta) conjugate frequencies measured by flow cytometry analysis at different effector-to-target ratios. The perils of medical tourism: NDM-1-positive Escherichia coli causing febrile neutropenia in a medical tourist.

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Adaptor ligation PCR (AL-PCR) of genomic DNA flanking T-DNA borders does not have these drawbacks and seems to be an adequate alternative to genomic DNA blot hybridization. Therefore, ICP4 is likely involved in the recruitment of these key cellular chromatin remodeling and transcription factors to viral genomes. Concentrations of IL-6 and IL-8 are increased during and after OLV in thoracic surgery. For HIV-1, obstacles to eliciting protective neutralizing antibodies (NAbs) have often seemed insurmountable. The Long Beach Longitudinal Study: evaluation of longitudinal effects of aging on memory and cognition. The results in this study confirm the predictive validity of the MPI-S subgroup classification system. The potency of PF1022A in reducing motility is greater than commercial anthelmintics.

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New 6beta,19-bridged steroid analogs of androstenedione, 6beta,19-epithio- and 6beta,19-methano compounds 11 and 17, were synthesized starting from 19-hydroxyandrostenedione (6) and 19-formylandrost-5-ene-3beta,17beta-yl diacetate (12), respectively, as aromatase inhibitors. Two patients suffered from closed high-energy periarticular elbow injuries. Predicting factors of malignancy in dermatomyositis and polymyositis: a case-control study. Successful treatment of partial graft failure after matched unrelated donor stem cell transplantation by a combination of ancestim (stem cell factor) and granulocyte colony stimulating factor in a patient with heavily pre-treated chronic lymphocytic leukemia. Visualization can be improved using reconstructed 3D ultrasound volumes. In addition, the growing need and interest in sports and successes in professional sports have become a symbol of international recognition and. We addressed uncertainty through one-way deterministic and probabilistic sensitivity analyses, extended the model to lifetime horizon and by another arm to compare first-line versus second-line use of bevacizumab on progression, performed value of information analysis, and performed US costing sensitivity analysis. They also studied the association between CDH1 hypermethylation and patient demographic characteristics using multivariate analysis and examined the impact of CDH1 hypermethylation on patient survival using both univariate and multivariate methods.

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Endocytic downregulation is a pivotal mechanism turning off signalling from the EGF receptor (EGFR). Photosensitivity is rather mild, but squamous cell carcinomas develop on sun-exposed areas mainly after the age of 40 years. Ergonomic interventions not only concur in the management and control of negative events for workers health but also in achieving advantages in terms of lower costs and greater productivity. We carried out a comprehensive search of nine databases--AMED, BIOSIS, CENTRAL, CINAHL, Cochrane Methodology Register, EMBASE, MEDLINE, Science Citation Index, and PsycINFO--from 1966 to 2012 and performed citation searches using the ISI Citation Indexes and Scopus. The ICD shocks are a unique aspect of treatment and have the potential to cause psychologic distress. Treatment effects on mortality were calculated as rate differences in each study (negative values favor steroids), and were combined with respect to the variability in each study. Several years after treatment, the vast majority of Venezuelan patients did not possess circulating anti-LID-1, anti-ML0405, and anti-ML2331 IgG, and the seropositivity of the remaining cases could be attributed to irregular treatment.

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A 14-year-old boy, with acquired haemolytic anaemia secondary to paravalvular leak from a prosthetic aortic valve, presented with severe pancytopenia. Using a Coulochem electrode array system, we investigated the developmental changes of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy. At days 0, 7, and 21 total and differential peripheral white blood cell (wbc) counts, together with full mouth plaque and gingivitis scores, were recorded. In vivo and in vitro effects of lysine clonixinate on nitric oxide synthase in LPS-treated and untreated rat lung preparations. The pathological features of the cancers in gene carriers show differences from those occurring in normal women.

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