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Nuvigil (Armodafinil)

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Nuvigil is a medication that promotes wakefulness. Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Nuvigil may also be used for purposes not listed in this medication guide.

Other names for this medication:
Armod, Armodafinil, Biryth, Waklert

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Also known as: Armodafinil


Nuvigil is a prescription medication used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders: narcolepsy, obstructive sleep apnea (OSA), shift work disorder (SWD).

Nuvigil is used with other medical treatments for this sleep disorder. Nuvigil does not take the place of using your CPAP machine or other treatments that your doctor has prescribed for this condition. It is important that you continue to use these treatments as prescribed by your doctor.

Nuvigil is in a class of medications called wakefulness-promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Nuvigil is usually given for up to 12 weeks. Follow your doctor's instructions.

Nuvigil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.

If you are taking Nuvigil to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.

Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and Nuvigil may be necessary to best treat your condition.

Nuvigil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.

Taking this medication does not take the place of getting enough sleep. Talk with your doctor if you continue to have excessive sleepiness even while taking Nuvigil.


When a person takes too much Nuvigil, overdose symptoms may include unusual bruising or bleeding, nausea, diarrhea, and chest pain. Specific effects will be based on certain factors. If the Nuvigil overdose was recent, healthcare providers may give certain medicines, place a tube in the stomach to pump the stomach, or treat the symptoms that occur as a result of the overdose.


Store Nuvigil at 20 to 25 deegres C (68 to 77 degrees F).

Keep this and all medicines out of the reach of children.

Nuvigil is classified as federally controlled substance (C-IV), because it can be abused or lead to dependence. Keep Nuvigil in a safe place to prevent misuse and abuse.

Side effects

The most common side effects associated with Nuvigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use this medication if you are allergic to Nuvigil or modafinil (Provigil).

Before using Nuvigil, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, a heart valve disorder, a history of mental illness, a history of drug or alcohol addiction, or if you have recently had a heart attack.

Nuvigil may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid other dangerous activity until you know how this medication will affect your level of wakefulness.

Stop taking Nuvigil and call your doctor if you have a skin rash, no matter how mild. A medicine similar to Nuvigil has caused severe skin reactions serious enough to require hospitalization. Other signs of a severe reaction include fever, sore throat, headache, and vomiting with a severe blistering, peeling, and red skin rash.

There may be other drugs that can interact with Nuvigil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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Influence of nephron mass and a phosphorylated 38 mitogen-activated protein kinase inhibitor on the development of early and long-term injury after renal warm ischaemia. Tardy posterior interosseous nerve palsy due to childhood osteomyelitis: a case report. Graft-versus-host disease was not detected in the pancreas recipients. Data regarding the renal effects of vasodilatory therapy in acute heart failure are inconclusive. The results of the analysis demonstrate that medication adherence, persistence, and discontinuation rates are suboptimal in patients with T2DM prescribed OAHAs. We suggest the completion of our previously published sepsis classification due to the immune status at the onset of sepsis: type A as the spontaneously acquired sepsis and type B as sepsis in trauma-induced pre-existing immune suppression. Lacunarity, derived from quantitative analysis of gluten network, is suggested as a new indicator for wheat quality. This research documents 7 patterns and identifies common driving and restraining forces. Morphometric detection of incipient glomerular lesions in diabetic nephropathy in rats.

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Campylobacter fetus is recognized as a human and animal pathogen. According to the machine, a 360 degrees rotation of the tube is obtained in 0.5 to 0.8 sec. Integrated planning and spatial evaluation of megasite remediation and reuse options. Deuterium labeled linoleic acid 17,17,18,18,18-d(5)-(9Z,12Z)-octadeca-9,12-dienoic acid (d(5)-LA) was synthesized to facilitate the detection and characterization of the protein modifications by mass spectrometry. Immunoreactivity for TGF-beta 1 and -beta 2 was present in the ganglion cell layer and photoreceptor outer segments of the normal adult rat retina. There is no series in literature, to the best of our knowledge, regarding the results of revision of the Souter-Strathclyde prosthesis (SSP) to the Coonrad-Morrey prosthesis (CMP). The stomach was identified as the primary site of GI colonization as determined by fluorescent in situ hybridization.

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Using this strain, we investigated whether the identified genetic evolution of NDV is accompanied by antigenic evolution. Taken together, these results demonstrate that the interaction between MdmX and ARF represents a novel pathway for regulating Mdm2 protein levels. To our knowledge this is the first reported case of feline choroidal melanocytoma. Evaluation of the inferior alveolar canal by cross-sectional hypocycloidal tomography. Consistent with the imprinted status of the genes in the region, Beckwith-Wiedemann syndrome (BWS) and Wilms tumor are each associated with loss of maternal information. In five focus groups involving 21 participants, the Medical Expert and Professional roles were seen as most relevant to an EM rotation, whereas the Health Advocate, Manager, Scholar, and Collaborator roles were least relevant. Cardiovascular disease (CVD) is a well-known complication of diabetes mellitus (DM), and patients with DM are at an increased risk for early onset of CVD.

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In the present paper we report a study of 20 patients with hereditary spherocytosis (HS) performed with the aim of provide further information on the electrophoretic abnormalities of red blood cell (RBC) membrane proteins and their putative relationship with the clinical, biological and genetic aspects of the disease. Improved hospital administration, expanded training programs, educational work by local mental health societies and modification of laws on malpractice and commitment will go far to help solve these problems. Clinical data of workers (40-69 yrs) operating chain saws for a ten-year period from 1986 to 1995 were analyzed to assess the evaluation standard of finger skin temperature for a cold provocation test (10 degrees C 10 min). Complex formation between NRIP and calcium/calmodulin activates the phosphatase calcineurin to dephosphorylate E2 and increase E2 protein stability. CAP cleaved big endothelin-1 at different sites when compared with that of other known aspartic proteinases, and it suppressed endothelin-1 production through the degradation of big endothelin-1. It was found that the presence or absence of limb preference, identified in short preliminary tests, often did not coincide with the nature and degree of lateralization formed during the process of prolonged training. Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension. Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2. Taken together, our findings suggest the involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups. Our results indicate that IL-12 can down-regulate the autoimmune component of this experimental syndrome and that the various manifestations of mercury-induced autoimmunity are independently regulated.

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A fragment of DNA containing a site that is uniformly methylated on the macronuclear chromosome was moved to a new location on the extrachromosomal rDNA. The relationship between such changes and cognitive function remains unclear. The QTL-MAS workshop offers the opportunity to test different methods to perform a genome-wide association study on simulated data with a QTL structure that is unknown beforehand. The isolated Au (III) complex is stable for about 1.5 months, while the stability of the Au (III) complex/DNA adduct is decreased to 33 days. The following is already known about MC540: firstly, MC540 exists in distilled water in both monomeric and dimeric forms, and the addition of salts into a MC540 solution leads to the formation of large aggregates that can be detected by the resonance light scattering technique. One proprietary software package calculates three 3D vascular indices: the vascularization index (VI), the flow index (FI), and the vascularization flow index (VFI). The present study was designed to determine if OFQ similarly attenuates cocaine-induced motor stimulation and to determine if this effect is dependent on attenuation of the increase in extracellular DA. Our results suggest that during the first trimester of normal pregnancy, active renin concentration in the plasma is increased and that renin is not the factor that limits angiotensin II synthesis. The diagnosis of laryngeal papillomatosis was made when she was 17 months old.

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Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes. Specific phosphorylation events are associated with the spatial and temporal coordination of these different activities. Several PET/CT-related parameters, including SUV(max), and various thresholds of metabolic tumor volume, total lesion glycolysis, and PET/CT-based tumor width (TW) were measured. RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. As HSCs are able to supply blood cells for the lifespan of the individual, LT-HSCs undergo an aging process. The carcinogenic effects of benzoquinones produced by the flour beetle. We propose a diagnostic algorithm based on the evaluation of GERD symptoms, the test results with a single dose of alginate with heartburn and EGD--esophagogastroduodenoscopy data. The device exploits, whenever possible, optical fibers, in order to simplify the alignment and to improve the stability.

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The main goal is to compare the degree of the cross-reactivity between Salsola kali and Salsola imbricata, and secondly to compare the various common allergen components between Salsola kali and Salsola imbricata. Functional role of estrogen metabolism in target cells: review and perspectives. Nasolabial follicular sebaceous casts: a novel complication of isotretinoin therapy. The English version of the DLQI was translated according to standard procedures and the translated version was validated among 200 outpatients attending the dermatology clinics at the National Hospital of Sri Lanka and 30 healthy volunteers. Only a few cases of cutaneous metastasis from follicular thyroid carcinoma are reported in the English language literature. This study was conducted to evaluate the results of treating hypertrophic nonunion of mid-shaft clavicle fracture with a limited contact dynamic compression plate (LC-DCP) without autologous cancellous bone graft. A significant decrease in phagocytic activity of hemocytes was observed in clams exposed to 10(-6) M of HgCl(2) for 28 days. The acetabular rim is a highly specialized structure known as the labro-acetabular complex.

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This study represents an audit of COPD diagnosis and management in primary care practices in Devon. HI-6 has been safely used in individuals to treat OP insecticide poisoning, as well as in human volunteers, although its efficacy against OP nerve agent poisoning in humans cannot be demonstrated due to ethical considerations. Eleven out of 19 selected articles showed the highest correlation between atypical glandular cells with benign diseases and six with squamous pre-malignant lesions. Such structures of BHK-21 cell and mouse liver cell are similar to that of HeLa cell. Tobacco floral homeotic geneNfbp6 is specifically expressed during pollen and ovule development. Queen-produced pheromones have long been believed to be the main factor inhibiting the differentiation of new reproductive individuals. A typical acoustic cycle of compression and rarefication of the acoustic wave is observed in the A-REMPI. The multifactorial pathway leading to preterm labor possibly includes the implication of apoptosis. Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. Prognostic value of admission red blood cell distribution width in acute pancreatitis: a systematic review.

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Intensive insulin therapy can attenuate the abnormity of oxidative stress and the levels of serum circulating adhesion molecules in patients with hyperglycemia crisis. Coronary artery calcification on electron beam computed tomography: a 6-year follow-up study of HIV-infected patients. The oxidatively deteriorated Pt nanoparticle catalytically decomposed ascorbic acid, which is one of the most important biological antioxidants. In addition, sequencing of phenergan dissolving tablets the TP63L (p63) gene, residing at 3q27, remained normal in the presented patient. A patency capsule (PC) is used to assess intestinal patency in patients with known or suspected stricture, but PC localization by plain abdominal X-ray (AXR) is difficult in those patients in whom the PC is not detected in the feces. Evidence supports the use of pulmonary rehabilitation to effectively manage psychological morbidity in COPD. The additional distension of the descending colon at a distending volume of 0.25 l augmented the response of decrease in coronary blood flow caused by the first two levels of gastric distension, but it did not have any further effect when added to the higher level of gastric distension.

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This case strongly suggests that it is important to understand the positional relationship of the inferior mesenteric and renal arteries by preoperative assessment using either 3-D CT angiography or magnetic resonance angiography. We demonstrate the potential of the technique by applying it to a variety of difficult ligase reactions. Melanocytes were depleted at the dermo-epidermal junction and formed aggregates in the epidermis. Analyzing the modified rankin scale using concepts of is 50 mg of coreg too much the international classification of functioning, disability and health. Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. Complex hemodynamical investigations were done in 32 patients in 1985-1999 yr. Socioeconomic inequalities in stage at diagnosis and survival of breast cancer may not always be explained by lower likelihood of suspecting cancer and subsequent impact on help-seeking. To determine whether, as mandated by Brazilian law, health care (outpatient care, hospitalization) among older community residents is based on health-related criteria and not on other characteristics. Severe tissue trauma results in a general inflammatory immune response (SIRS) representing an overall inflammatory reaction of the immune system.

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Monobase-conjugated apoferritin probes were coupled to the mutant sites of the formed duplex DNA in the presence of DNA polymerase. PtCl4(Fast Black)2 and hyperthermia were additive over a wide range of scheduling from heat exposure 2 h prior to 5 h after fenofibrate 200mg brand name drug exposure. Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. We evaluated the function of human immunodeficiency virus type 1 vpu gene in various cell lines. The Changing Pattern of Published Articles in the Field of Otology: 1818 to Today. AMPs have been described to perturb protozoan homeostasis by disrupting the cellular membranes but also by interfering with key processes in the parasite metabolism.

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In 363 donors, psychological (donation-stress and arousal) and hormonal (cortisol) stress were measured by questionnaire and salivary sample at seven key moments during a routine donation. Long term survival in a patient with aggressive Rosai-Dorfman disease treated with interferon alpha. In some B-chronic lymphoproliferative disorders, the over-expression of cyclin D1 protein is thought to confer a proliferative phenotype. Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge. The economic evaluation was based on double-blind randomised controlled trials of vasoactive agents previously reported as Cochrane meta-analyses. Oxidative and nitrosative stress caused by a disturbance in the homeostasis of pro-oxidants and antioxidants play a vital role in the pathogenesis of coronary heart disease (CHD). With a better understanding of therapeutic options other than compression therapy the care for each individual patient may be optimized.

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Red squirrels are the predominant predispersal seed predator and selective agent on lodgepole pine cones. The advent of highly active anti-retroviral therapy (HAART) has extended the lives of patients affected by human immunodeficiency virus (HIV) disease. No differences in the mouth alcohol elimination patterns were observed. Peritoneal dialysis in acute kidney injury: Brazilian experience. In GPR3 -/- mice, the IGL was widened with increased proliferation of CGPs, as measured by bromodeoxyuridine incorporation. Clouston, whose eponym is attached to a type of hidrotic ectodermal dystrophy, and a brief account of the mapping of the gene and its identification as the connexin gene, GJB6. Liposomes were fluorescently labeled with membranotropic cost of ventolin in usa rhodamine-phosphatidylethanolamine or by entrapping FITC-dextran. Experience in developed countries has shown that they reduce the incidence of invasive and non-invasive disease. Diagnosis of recurrent astrocytoma with fludeoxyglucose F18 PET scanning.

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