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Lodine (Etodolac)

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Lodine is used to treat the symptoms of rheumatoid arthritis and osteoarthritis by reducing inflammation, swelling, stiffness, and joint pain. Each tablet contains 600mg of the active ingredient etodolac.

Other names for this medication:
Etios, Etobest, Etodolac, Etofree, Etogesic, Etomax, Etoron, Etosafe, Etova, Etura, Freeup, Penalgon, Proxym, Setolac, Toldin

Similar Products:
Lopid, Detrol, Differin, Decadron, Duphaston, Ledric, Richpram, Methopar, Prostin, Zeroworm, Arcolane, Spinofen, Cetpine, Ziglim,

Also known as: Etodolac


Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (eg, osteoarthritis and rheumatoid arthritis), including inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain etodolac. It may not be specific to Lodine XL. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients.

This medicine should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Swallow the extended-release tablet whole. Do not crush, break, or chew it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute pain: For oral dosage form (capsules or tablets): Adults—200 to 400 milligrams (mg) every 6 to 8 hours. However, the dose usually is not more than 1000 mg per day. Children—Use and dose must be determined by your doctor.

For osteoarthritis and rheumatoid arthritis: For oral dosage form (capsules or tablets): Adults—300 milligrams (mg) 2 to 3 times a day, or 400 or 500 mg 2 times a day. Your doctor may lower your dose to 600 mg once a day. The dose usually is not more than 1000 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—400 to 1000 milligrams (mg) once a day. Children 6 to 16 years of age—Dose is based on body weight and must be determined by your doctor. Children younger than 6 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, stomach pain, or stomach bleeding.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Lodine XL dosage information

Side effects

The most common side effects associated with Lodine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of etodolac in the elderly. However, elderly patients are more sensitive to the effects of etodolac than younger adults, and are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving etodolac.

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Clinical and radiological evaluation of malignant metaplasia of benign primary bone tumors on the material of University Orthopaedic Department of Szczecin between 2002-2007. The overlap of age-associated differential gene expression in HPC and MSC was moderate. However, when tested in ELISA-based assays and in adhesion assays with ST88-14 cells, in contrast to Hlp, S4 and S5 failed to bind laminin and act as adhesins. For two years before this presentation, serology showed abnormally high titres to EBV early antigen, suggestive of persistent infection with EBV. The advantages of this technique include the avoidance of large areas of craniectomy and immediate correction of the cranial deformity. In this study, we investigated whether race could be decoded from distributed patterns of neural activity in the fusiform gyri and early visual cortex when visual features that often covary with race were orthogonal to group membership. We retrospectively analyzed dose-volume histograms (DVHs) and clinical records of 73 cirrhotic patients treated with 3D-CRT for HCC. This increase of loss is attributed to both a permanent increase of loss-inducing color centers and a temperature-dependent broadening of the absorption spectrum. Enterobacter sakazakii infections among neonates, infants, children, and adults. Therefore, our aim was to analyze VP scenarios integrated into the combined internal medicine and surgery curriculum at the University of Munich (LMU) and compare the results with data from the population in Germany.

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