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Indocin (Indomethacin)
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Indocin

Indocin is a non-steroidal anti-inflammatory drug, also known as an NSAID. It treats pain, inflammation, and swelling. Indocin works well for moderate to severe pain. It should be used carefully when taken long-term since it has some serious side effects.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Also known as: Indomethacin

Description

Indocin is a nonsteroidal anti-inflammatory drug (NSAID).

Indocin is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. This medicine is also used to treat shoulder pain caused by bursitis or tendinitis.

Extended-release Indocin (Indocin SR) should not be used to treat gouty arthritis.

Dosage

Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.

Swallow the extended-release capsule whole and do not crush, chew, break, or open it.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Your dose needs may change if you switch to a different brand, strength, or form of Indocin. Avoid medication errors by using only the form and strength your doctor prescribes.

If you use this medicine long-term, you may need frequent medical tests.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

Detailed Indocin dosage information

Overdose

If you overdose Indocin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Indocin overdosage: vomiting, migraine, lightheadedness, confusion, extreme tiredness, feeling of numbness, pricking, burning, creeping on the skin, convulsions, dyspepsia.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Indocin dosage information

Side effects

The most common side effects associated with Indocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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To investigate the stage-specific and tissue expression of bone sialoprotein (BSP) and osteopontin (OPN) during reparative dentinogenesis in vivo. It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. Phantom solutions containing several cerebral metabolites at physiological concentrations were evaluated initially for sequence optimization. Specifically, the increased egg production and high fertilization success within reserves is more than offset by the reduced egg production and fertilization success in the fished areas, relative to a system in which fishing mortality is distributed more evenly over the entire system. Our findings suggest that i) RUNX3 has an oncogenic role in HNSCC, ii) RUNX3 expression observed in HNSCC may be caused in part by demethylation during cancer development, and iii) RUNX3 expression can be a useful marker for predicting malignant behavior and the effect of chemotherapeutic drugs in HNSCC.

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Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study. The primary outcome measure was pain relief and the secondary outcome measure was functional improvement. Mitochondria isolated from maize containing cms-T cytoplasm are specifically sensitive to pathotoxins (T-toxins) produced by the fungi Bipolaris maydis race T and Phyllosticta maydis. Contrast-enhanced multidetector cardiac computed tomographic angiography (CCTA) has high sensitivity and specificity for diagnosing anatomic coronary stenoses, but its role in predicting late clinical outcome events has not been well studied. Diagnosis of imported malaria by Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein 2 (PfHRP-2)-based immunocapture assays.

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Synthesis of triazenoazaindoles: a new class of triazenes with antitumor activity. Such marking behavior may be common in birds, and we may now be exploring other questions and mechanisms in territoriality. The placenta is positioned between the maternal and fetal circulation and hence plays a key role in transporting maternal nutrients to the developing fetus. The new grading system of screw misplacement was feasible and in line with the general agreement about the harmlessness of misplacement with minor pedicle breach. This is true in laboratory experiments and clinical trials and pertains to efficacy, safety, and the resulting benefit/risk ratio. The process model for Penicillin production is based on a detailed morphological description of growth of hyphal filaments and pellets. The influence of betahistine on the dynamics of the cutaneous hypersensitivity reaction in patients with grass pollen allergy. The event-specific molecular markers developed in this investigation are crucial for regulatory requirement in some countries and intellectual protection. This result suggests that suppression of Hd3a expression is a principle cause of late heading under low temperature and long-day conditions. However, a broader use of this technology in biomedical research is limited by a lack of protocols that enable the short-term preservation of preassembled liver-on-chip models for stocking or delivery to researchers outside the bioengineering community.

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Early mortality in women after acute myocardial infarction is higher than in men in the RICVAL Register. Finite element analysis of the stability of transverse acetabular fractures in standing and sitting positions by different fixation options. But the plasma aldosterone level which was increased in SHR was not changed by amlodipine. Neurons in one of its subdivisions, the lateral intraparietal area (LIP), have visual responses to stimuli appearing abruptly at particular retinal locations (their receptive fields). The values of the examined parameters of the patients from the experimental group were significantly lower in comparison with those of the patients from the control group. The two transgenic lines show no elevation of NF-L, neurofilament middle chain (NF-M), or neurofilament heavy chain (NF-H), and transgenic NF-L(Asp) represents only a minor proportion of total NF-L protein. This knowledge is particularly important in slow growing organisms, like mycobacteria, where most of the viable anti-tubercular agents are bactericidal. By pulsed field gradient 1H-NMR, the diffusion coefficients of all three components in a cubic phase composed of soybean phosphatidylcholine, diacylglycerol, and heavy water have been determined at 25 and 59 degrees C and also for the corresponding cubic phase composed of the chemically more well defined synthetic components 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dioleoylglycerol (DOG), and heavy water. Cell mediated immunity is important in recovery from CMV infection. Detoxification of a carcinogenic paint preservative by Blumea malcolmii Hook cell cultures.

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Simultaneous measurements of X-ray reflectivity and grazing incidence fluorescence at BL-16 beamline of Indus-2. Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare, benign disease of unknown aetiology. BOLD new directions in myocardial ischemia imaging-myocardial oxygenation assessment by cardiac magnetic resonance. A case control study of 157 high-risk patients, matched on Gleason score and stage with systemic progression or death of prostate cancer as the end point, was used to evaluate the expression of candidate genes and build a multivariate model. In the acute phase of the disease, the titers of anti-GQ1b and GT1a antibodies were elevated. Development of new methods to assess the outcomes of emergency care.

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Three of five patients with persistent disease underwent repeat bone marrow biopsies. In order to identify candidate genes responsible for dominant and submissive behavior, we applied transcriptomic and proteomic studies supported by molecular, behavioral and pharmacological approaches. For each worker, manganese concentrations in blood and urine were measured, and a cumulative exposure index was also calculated. Pesticides have been implicated as potential causative factors for gastroschisis, and use of restricted use pesticides (RUPs) is widespread in Hawaii. The selection of marmoset monkeys (Callithrix jacchus) in pharmaceutical toxicology. The associated alteration of CVR in the absence of other apparent causes of cerebrovascular impairment suggests that cognitive problems may be related to an alteration in cerebral perfusion regulation specifically linked to the disease. The N-terminal 10 amino acid residues contain the signal necessary for translocation through both systems. This article explains why patients may no longer be able to look after their own feet and aims to give health professionals guidance on foot problems, assessment and care, and advise them on when it is appropriate to refer patients for specialist advice. New idea of a small-sized neutron detector with a plastic fibre. ATP-dependent chromatin remodelling activities can facilitate transcription from chromatin templates.

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By studying the electrochemical growth and dissolution of a Ni monolayer on a PdAu bimetallic surface with in situ STM, we demonstrate that Ni grows preferentially on Au(111) in a wide potential range. Rhabdoid tumors (RT) are aggressive pediatric malignancies with poor prognosis. Indeed, PC mapping on topography-less patterned porous-silicon/silicon samples shows that the lateral resolution is only limited by the aperture size which is of the order of 100 nm. Retinol potentiates acetaminophen-induced hepatotoxicity in the mouse: mechanistic studies. After autotransposition the neural function was preserved, albeit the amplitude of the contractile response to EFS was smaller than in controls. Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma. Multicenter Prospective Comparative Study of Robotic Versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma. Here we studied the spatiotemporal mechanisms of band 3 multiprotein complex assembly during erythropoiesis. Even when some aspect of a PACU visit was disturbing, patients and families expressed a desire for visitation. Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.

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However, the ability to culture undifferentiated ES cells without the use of feeder cells as well as means to obtain homogeneous, differentiated cell populations devoid of residual pluripotent ES cells still remain major challenges. The proliferation of T24 cells was significantly inhibited by different concentrations of curcumin combined with cisplatin. This model provides a rapid in vivo test for new agents to treat wound biofilm infections. Sprague-Dawley rats were bled (20 or 15 ml/kg) 4 days after cannulation. Factors including heritability, climate features, co-morbid diseases and methodological differences between studies may underlie variation in the prevalence of restless legs syndrome (RLS). The SPIR group achieved normal speech results at all points of evaluation. Synchrotron X-ray study of lung surfactant-specific protein SP-B in lipid monolayers. The loading behavior of a Cu/Nb multilayer material is used to demonstrate the use of the detector in a strain-stress experiment. Corneodesmosomes are degraded from the central surface area of each cell.

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