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Daklinza (Daclatasvir)
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Daklinza

Daklinza is approved for use with Sovaldi (sofosbuvir) for the treatment of chronic hepatitis C genotypes 1 and 3. Testing prior to initiation: HCV genotype 1a with cirrhosis, consider testing for the presence of virus with NS5A resistance-associated polymorphisms.

Other names for this medication:
Daclatasvir

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Also known as: Daclatasvir

Description

Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

Daklinza is used in combination with other medications to treat chronic hepatitis C in adults.

Daklinza treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Daklinza must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

Daklinza is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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Identification of the sequence motif of glycoside hydrolase 13 family members. Detection of IgG in cerebrospinal fluid for diagnosis of neurocysticercosis: evaluation of saline and SDS extracts from Taenia solium and Taenia crassiceps metacestodes by ELISA and immunoblot assay. These transcriptional triggers include known and novel regulators that respond to carbon, nitrogen and oxygen limitation. Cultures, habits, traditions, psychiatric illness, and epilepsy are strongly correlated to burn patterns. The ICD/AIS MAP was used to convert all injury related ICD-9-CM diagnosis codes into abbreviated injury scale (AIS) score and injury severity score (ISS). The CCO activity inhibition was highest in the brain, although the cyanide concentration was lowest level. Do time-averaged, whole-building, effective volatile organic compound (VOC) emissions depend on the air exchange rate?. Little research has been conducted analysing the organisational risks that compound and trigger dispensing and medication errors. Although cases with a familial pattern are noted in a few publications, sporadic cases have been reported without a family history.

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To identify factors associated with remaining healthy in older adults. The review finds that while sales promotions lead to significant sales increases over the short-term, this does not necessarily lead to changes in food-consumption patterns. In these tumours, HPV-oncogenes might lead to distinct alterations in metabolic pathways. Endocrine tests demonstrated partial hypopituitarism with alteration of the somatotropic, gonadotropic and corticotropic axis and moderate hyperprolactinaemia. Radiological course of cemented and uncemented trapeziometacarpal prostheses. Trypanosoma cruzi infection is often not detected early on or actively diagnosed, partly because most infected individuals are either asymptomatic or oligosymptomatic. The primary outcome was remission, defined as ratings of less than 8 and less than 6 on the last two consecutive applications of the 16-item Quick Inventory of Depressive Symptomatology--Self-Report. Interestingly, although a similar set of enzymes are modulated in the same direction in mature DCs and Mphis, cell specific genes are also differentially regulated during maturation, a phenomenon that may sustain functional specificities. In this proof-of-concept study, we tested the hypothesis that combined analysis of multiple genetic variants can improve prediction. In microdialysis studies, LY367385 and CPCCOEt substantially enhanced GABA release in the corpus striatum of freely moving animals, whereas MPEP had no effect on GABA but abolished the stimulation of glutamate release induced by NMDA.

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We investigated whether maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), total lesion glycolysis (TLG) and whole-body (WB) SUVmax, WB MTV and WB TLG measured by (18)F-FDG PET/CT could improve prognostic stratification in patients with stage II/III breast cancer (BC). In conclusion, data of the present study indicate that, like CETP, the activity of PLTP is influenced by electrostatic interactions with lipoproteins. Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. Genetic, viral, and lifestyle factors may explain these ethnic differences in the incidence of NPC. Microscopy has become increasingly important for analysis of cells and cell function in recent years.

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PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. The experiments show that the fragmentation is controlled by the S1-lifetime of TBFC and, dependent on the solvent, within 0.8-2.1 ps leads to tert-butyloxy and methylfluorenyl radicals plus CO2 via concerted bond breakage of the O-O and the fluorenyl-C(carbonyl) bond. We also propose to select pixels of smooth area for data embedding and leave rough pixels unchanged. Xylem structure of four grape varieties and 12 alternative hosts to the xylem-limited bacterium Xylella fastidious. The results of our survey suggest that routinely issuing clinical magnets to ICD patients is a safe and effective practice, and a small but significant number of patients were able to utilise their magnets in clinically important situations. Intestinal secretion was monitored electrophysiologically as transmucosal short circuit current (Isc). More particularly very little is known about the role of cell cycle genes p57(kip2) and Rad9 during chemoprevention by turmeric and its derivatives especially in prostate cancer cell lines. Rayner, Fischer, and Pollatsek (1998, Vision Research) demonstrated that reading unspaced text in Indo-European languages produces a substantial reading cost in word identification (as deduced from an increased word-frequency effect on target words embedded in the unspaced vs. Palliative radiotherapy should be offered to elderly patients when needed. The hydrogen bond donating ability of the solvents also assists in protein swelling.

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Water and food intake suffers and pulmonary contamination leads to lung infection. VLA-6 integrin distribution and calcium signalling in capacitated boar sperm. Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences. The results showed that although vaginal isolates did not cluster in any particular genetic subtype, multiple patients were infected dog diarrhea imodium dosage with indistinguishable strains (there were nine distinct strains among 23 isolates). The women targeted by voucher outreach workers were poorer, less educated, and at higher parity. The aim of this study was to examine the quality of handover of patients in the resuscitation room by describing the current perceptions of medical and ambulance staff. Ferrocenecarboxylic acid esters of various alcohols and phenols have been synthesized, separated by reversed-phase HPLC and oxidized (ionized) coulometrically prior to single quadrupole MS analysis using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces. The study tests the effect of acute moderate doses of alcohol on divided and covert attention in right-handed, male volunteers. To evaluate the potential cardiovascular risk of diabetics in performing esophagogastroduodenoscopy (EGD), we compared the autonomic function and cardiovascular parameters during EGD between diabetic and nondiabetic patients. A novel GH-1 gene mutation (GH-P59L) causes partial GH deficiency type II combined with bioinactive GH syndrome.

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Comparative genomic hybridization study of nasal-type NK/T-cell lymphoma. Intron 9 was not retained in normal keratinocytes or cell lines. Chromatographic studies of unusual on-column degradations of aniline compounds on XBridge Shield RP18 column in high pH aqueous mobile phase. Additionally, we validate the use of nasal swabs as an alternative to venous blood or buccal samples from animal subjects for reliably producing high quality genotypes on this platform. The effect of Cx43 on a proapoptotic factor, Bax, was then investigated. Social support may have a protective effect against suicide on a regional level. After 1 year of GH replacement, total and LDL cholesterol and QoL improved in all BMI, WG and FM groups. Improving the affordability of radiotherapy through publicly funded transport and radiotherapy at out of area facilities did not improve BCT uptake in a region where radiotherapy was locally available, albeit at cost to the user.

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Seven lignans (2-8) isolated from the seeds of Hernandia ovigera L. We propose, however, that additional synergetic effects can be achieved by simultaneously combining both approaches. Effects of rice seed surface sterilization with hypochlorite on inoculated Burkholderia vietnamiensis. Scytalidium dimidiatum melanonychia and scaly plantar skin in four patients from the Maghreb: imported disease or outbreak in a Belgian mosque?. These simulations showed that current state-level wetland regulations protecting 30 m or less of surrounding terrestrial habitat are inadequate to support viable populations of pool-breeding amphibians. Detecting angiogenesis in breast tumors: comparison of color Doppler flow imaging with ultrasound-guided diffuse optical tomography. The 10th child had both gastroduodenal and jejunal involvement, but scintigraphy only revealed faint jejunal positivity.

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