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Cardiorex (Diltiazem)

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Cardiorex is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Cardiorex is used to treat hypertension, angina, and certain heart rhythm disorders.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Eldepryl, Myambutol, Kemadrin, Epivir, Effexor, Avodart, Cytoxan, Anxorel, Evonex, Kilpro, Zantid, Taxetil,

Also known as: Diltiazem


Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Diltiazem is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardiorex LA. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardiorex LA dosage information

Side effects

The most common side effects associated with Cardiorex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Cardiorex if you are allergic to diltiazem, or if you have:

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); very low blood pressure; or if you have recently had a heart attack and you have a build-up of fluid in your lungs.

To make sure Cardiorex is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; or if you also take digoxin, or a beta blocker (such as atenolol, carvedilol, metoprolol, propranolol, sotalol, and others).

It is not known whether Cardiorex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Diltiazem can pass into breast milk and may harm a nursing baby. You should not breastfeed while using this medicine.

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Curcumin (50 microM) and quercetin (250 microM) opposed such loss in papain inhibitory activity of GLC-I. In contrast, with HLA antibodies neither activation nor inhibition of the platelet function could be proven. Prognostic factors in peptic ulcer perforations: a retrospective 14-year study. Here, we focus on the impact of another selective sweep in the region of influence of a first one. Preliminary investigation of sequence-independent DNA binding proteins in rat skeletal muscle sarcoplasmic reticulum and their function. Conformational Dynamics of Two Natively Unfolded Fragment Peptides: Comparison of the AMBER and CHARMM Force Fields. Microscopic and biochemical analysis revealed drastic reduction in glycosome number and mislocalization of the glycosomal matrix enzymes to the cytosol. The incidence of neonatal mortality, prematurity, and small-for-gestational-age infants is increased in pregnancies associated with maternal renal replacement therapy. S100A12 is an endogenous receptor ligand of advanced glycation end-products. Immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring Leu-Pro-X-Thr-Gly motif, muramidase-released protein and surface antigen one, were absent in the DeltasrtA.

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During ECMO, starvation of the gut is common practice in many centres as splanchnic ischemia results in loss of intestinal integrity, which in turn predisposes for bacterial translocation and sepsis and eventually necrotizing enterocolitis (NEC) and multiorgan failure. Tissue injury occurs during freezing due to the actual formation of ice crystals within the extracellular fluid. Biological responses of a variety of naturally occurring compounds in vivo were restrained by their poor oral bioavailability. Chronic respiratory symptoms, bronchial responsiveness and dietary sodium and potassium: a population-based study. Ultrasound images included the kidneys, ureters and bladder to be consistent with practice. Our approach allows us to make a stable calculation for larger sets of renormalized coupling constants than either the Swendsen or the Gupta-Cordery methods, thus reducing the effects of truncation in renormalization-group calculations.

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The need for new initiatives in research into ageing in ASD is urgent. Systemic nontyphoidal Salmonella infection in normal infants in Thailand. This study showed that early weight-bearing after reamed static interlocking nailing of Winquist type II, III, and IV femoral fractures is a safe and effective method, and the risk of implant failure does not preclude the procedure. The capacity to respond behaviourally to frustrating conditions thus likely reflects an adaptive response to environmental unpredictability, which has been conserved throughout vertebrate evolution. Streptococcal infection, acute kidney failure and interstitial nephritis. Surprisingly, we found that the core skeletons of flavonoids instead of their substituents determine the extent of inhibiting CYP2D6 by a flavonoid extract.

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To assess the effectiveness of short-wave diathermy (SWD) treatment in the management of knee osteoarthritis (KOA) and to assess whether the effects are related to the induction of a thermal effect. A logistic model was developed to assess the impact of diet and exercise on diabetes diagnosis. Radiostereometric migration analysis of the Cerafit femoral stem: 28 patients followed for 2 years. To evaluate the clinical characteristics, risk factors, management and outcome of major pulmonary embolism (PE) in a tertiary care center of Karachi. However, it is currently unknown which tissue(s) contribute to this glucose-lowering effect. In vivo synthesis of MTH and of its independent domains in the presence of copper only afforded heterometallic copper-zinc species.

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An investigation of language used by children to describe discomfort during dental pulp-testing. Four eyes of three patients underwent technically uneventful LASIK. There was a wide range of measurement techniques and timing of scans. Does neoadjuvant chemotherapy increase optimal cytoreduction rate in advanced ovarian cancer?. Lipid formation by aqueous Fischer-Tropsch-type synthesis over a temperature range of 100 to 400 degrees C. Measles resurgence in Belgium from January to mid-April 2011: a preliminary report. Two useful definitions are proposed for describing motions of the shoulder mechanism. Maximum daily doses were 40 mg for baclofen and 0.8 mg for clonidine.

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South Asia is home to more than 1.5 billion humans representing many diverse ethnicities, linguistic and religious groups and representing almost one-quarter of humanity. This is supported by previous evidence from human psychology, as how much ventolin does it take to overdose well as new analyses demonstrating a positive relationship between allogrooming and facial nucleus volume. However, the emission coupled to the plasmonic modes must then be outcoupled into the far field before it succumbs to ohmic losses. However, in addition to the above conserved residues, Arginine (R60) also plays an important role in S. Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Gemcitabine Plus Cisplatin for Treatment of Metastatic Triple-Negative Breast Cancer After Failure with Anthracyclines and Taxanes. Four hemoparasites of cattle, Anaplasma marginale, Cowdria ruminantium, Theileria parva, and Babesia spp., are all dependent on ticks for biological transmission.

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We suggest that platelet activation, resulting in elevated RANTES release, could be one of the factors responsible for the increase of airway inflammation observed in consequence of EIB in asthmatics. We also describe several new bacterial polylinker vectors derived from pUC21 (ampicillin resistance) and pUK21 (kanamycin resistance). Most water-soluble and small molecules are taken up by substrate-specific channels belonging to the Gram-negative bacteria. Malignant endocrine disorders have been an enigma over the last few decades, from genetic, clinical, and imaging perspectives. The photoactivated Akt conferred protection against nutritional deprivation and H2O2 stresses to the cells significantly. This foot-to-shoe mismatch may result in deformities as well as discomfort and reduced performance or injuries in competitions. Members of a functional (non-coding) RNA family are affected by these variations not only on the sequence, but also on the structural level. Additionally, environmental factors such as perinatal stress and early adversities contribute to the occurrence and severity of ADHD. The assessed flavopiridol and cisplatin regimen displayed clinical activity in platin resistant and sensitive ovarian/primary peritoneal cancers, meriting further study. Therefore, we developed a novel calcium phosphate-binding liposome for a bone-targeting drug delivery system.

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CD40 ligand (CD40L)/CD40 costimulation is an important regulator of Th1 responses. Neither scientific analysis nor warmhearted concern are adequate to provide a practical understanding of how wars affect children. Our data are consistent with a model where Derlin proteins function in a spatially segregated quality control pathway that is used for the recognition and degradation of transmembrane proteins that become misfolded at the plasma membrane and/or in endosomes. A cross sectional study of black and white patients with focal glomerulosclerosis (FGS) or minimal change disease (MCNS) and black and white controls. The validation and the performance of the method are demonstrated through both simulated and actual bilateral auditory-evoked data experiments. Anterior restorations: Crowns, veneers, or direct composite--How do you decide?. We have previously shown that among extracellular signal-regulated protein kinases (ERKs), the 42 and 44 kDa isoforms (ERK1/2) as well as Akt and cytosolic phospholipase 2 (cPLA2) participate in the cellular mitogenic machinery triggered by several VSMCs activators, including insulin (INS). Exploring the Antipolar Nature of Methylammonium Lead Halides: A Monte Carlo and Pyrocurrent Study. Strong similarities in the electroclinical features and outcome between children with early-onset absences and those with CAE support the view that these conditions are part of the wide spectrum of IGE.

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Complexity and function of natural killer T cells with potential application to hepatic transplant survival. Maternal factors are sufficient for both the degradation and protection components of transcript localization. High levels of proteolysis and low levels of water-insoluble calcium were associated with decreased post-melt chewiness and whiteness of low fat Mozzarella cheese. Two hundred and eight patients with a history of allergy to local anaesthesia were referred over a twenty-year period to our Anaesthetic Allergy Clinic. Population pharmacokinetics modeling and analysis of foretinib in adult patients with advanced solid tumors. This study set out to investigate the potential for pharmacodynamic interaction between low-dose ASA and esomeprazole in healthy volunteers, by measuring ASA antiplatelet activity.

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Metallic behavior in the films is attributed to oxygen vacancy formation in the WO3 layer induced by the high electric field at the oxide-ionic liquid interface. Percutaneous transthoracic left atrial access is feasible without instrumenting the left ventricular myocardium. The neural substrates of probabilistic and intertemporal decision making. In vivo microdialysis in awake unrestrained rats was used to measure the effects of systemic administration and local infusion of cocaine on extracellular DA and 5-HT levels simultaneously in the NAc. The taxonomical structure of the polymorphic subgenus Rosa section Caninae is highly complex due to the combination of some unusual features: the unique polyploid chromosomal constitution, the heterogamic canina meiosis, the ability to hybridize interspecifically, and the predominantly matroclinal inheritance. High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease.

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The terminology has been developed by the International Federation of Cervical Pathology and Colposcopy Nomenclature Committee during 2009-2011. The high-resolution CT scan plays a what kind of medication is digoxin central role and makes it possible to prioritize the diagnostic possibilities. Individual amino acids have been implicated in BZD recognition and modulation of the GABA(A) receptor, but the secondary structure of the amino acids contributing to the BZD binding site has not been elucidated. Skin fibroblasts of patients with Cockayne syndrome (CS) are hypersensitive to the lethal or mutagenic effect of ultraviolet light, which may cause genetic instability. A specific inhibitor for histone deacetylase (HDAc) alleviates Evi-1-mediated repression of TGF-beta signaling, suggesting that HDAc is involved in the transcriptional repression by Evi-1. Moreover, in vitro experiments have shown that this protein can interact with the catalytic alpha subunit of casein kinase 2 enzyme, altering its activity.

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