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Calmef (Alprazolam)

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Calmef is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Calmef, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Calmef is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alamflu, Alcalm, Alpraquil, Alzoax, Alzolam, Alzotime, Ansilumirm, Anxigo, Anxigon, Anzilum, Axizox, Azicalm, Calmtec, Deproz, Destres, Dexolam, Emlol, Enxolam, Faxtin, Meloprax, Oclam, Onapract, Plaxid, Plxna, Propnix, Pyrex, Restyl, Rezolam, Sinaday, Stresnil, Texidep, Xanti, Zenax, Zotam

Similar Products:
Plavix, Biaxin, Zudena, Sustiva, Detrol, Xenical, Reminyl, Bystolic, Cefdinirum, Diazariv, Texis, Mecobest, Flunazul, Lecet,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Calmef dosage information


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Calmef XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Calmef XR dosage information

Side effects

The most common side effects associated with Calmef are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Calmef if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Calmef is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Calmef while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Calmef is not approved for use by anyone younger than 18 years old.

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Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability of endogenous antioxidant systems to scavenge ROS, where ROS overwhelms the antioxidant capacity. Loss-of-function experiments indicate that HPAT2, HPAT3 and HPAT5 function in preimplantation embryo development to modulate the acquisition of pluripotency and the formation of the inner cell mass. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. Patients with CD19-negative relapsed leukemia have very poor prognosis and novel approaches to treat and ideally prevent antigen-loss are direly needed. We examined studies that included people older than 16 years of age who had ABI of a non-degenerative nature and were participating in treatment programmes offered in hospital, outpatient, or community settings. TORC1, which is sensitive to rapamycin, regulates translation and cell growth, whereas TORC2, which is insensitive to rapamycin, regulates cell morphology and cell growth. The effects of zeranol, an anabolic agent, on the serum immunoglobulins of rabbits immunized with B.19 brucellosis vaccine. In all cases but one, the condyle was reduced by manual manipulation with the patient in general anaesthesia.

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In the University Hospital of Granada (Spain), 359 trauma surgical patients underwent intraoperative autotransfusion. Wear Improvement of Tools in the Cold Forging Process for Long Hex Flange Nuts. Tuning Zeolite Precursor Interactions by Switching the Valence of Polyamine Modifiers. Antibody-based therapies have garnered considerable success in recent years. Temperature effects on aerobic scope and cardiac performance of European perch (Perca fluviatilis). A new method of controlling lactic acid bacteria contamination was developed with the use of recombinant Saccharomyces cerevisiae strains producing antibacterial peptides. Thus sensitivity to P(FR) was cyclic.The interpretation of our experiments was complicated by quantitative morphological differences resulting from long, as compared to short, far red irradiations. The purpose of this in vivo study was to compare axillary artery blood flow velocity, and maximal handgrip strength and endurance performance in young subjects with and without an axillary arch (AA). The national audits provide a consistent picture of typical patients - an average age of 80 years, with less than a third being men, and a third of all patients having cognitive impairment - but there was surprising variation in the type of fracture, of operation and of anaesthesia and hospital length of stay in different countries. To assess the current evidence of high quality on the effects of acupuncture for patients with FD.

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Intra-Cluster Correlation Estimates for HIV-related Outcomes from Care and Treatment Clinics in Dar es Salaam, Tanzania. After performing single-subject independent component analysis, spatial maps and time courses were assigned to an auditory RS network template from the literature and compared via spatial regression coefficients. Preliminary results indicate several beneficial effects of early reperfusion with intracoronary streptokinase. To characterize the molecular composition of cross-linked actin networks (CLANs) and the regulation of their formation by what does ventolin tablets treat integrins in normal human trabecular meshwork (TM) cells. LX2-CM up-regulated the expression levels of p-ERK1/2, c-Myc, vimentin and down-regulated the expression level of E-cadherin. Although the primary role of autophagy in many organisms is in adaptation to starvation, autophagy is also thought to be important for normal turnover of cytoplasmic contents, particularly in quiescent cells such as neurons. Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers. Conversely seven of 24 patients with acute recurrent pancreatitis had an elevated basal SO pressure, with five patients having pressure elevation only in the pancreatic duct segment while two patients had abnormal basal SO pressure in both segments.

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We report two rare cases of 46, XY DSD, including XY pure gonadal dysgenesis and complete androgen insensitivity syndrome, who underwent a prophylactic gonadectomy. Deciphering the origin of mito-nuclear discordance in two sibling caddisfly species. Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy. A slightly modified commercial motor perfusor was chosen to power this device, which has proved to be good and fail-safe in more than 100 cases. Erratum to: Vertebral abnormality without spine-curvature deformity on prenatal ultrasonography: sonographic findings and postnatal radiographic correlations. This linker is removed in a NEK2A kinase-dependent manner as mitosis begins. Experiences with Calciparin, a new subcutaneously injectable heparin preparation. It is suggested that PACAP27 may exert its modulatory action on NMDA receptor channel activity through the glycine site(s). The Detection of Faking Good on the Personality Diagnostic Questionnaire-4.

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Prediction of nitrogen release from sigmoid-type controlled release fertilizers in greenhouse production of strawberry and cucumber. Particle-impact analysis of the degree of cluster formation of rutile nanoparticles in aqueous solution. Relationship between enzyme activities involved in oxygen metabolism and oxygen tolerance in black-pigmented Bacteroides. Endothelial damage besides other deep structural injury, which is the major concern of this technique have not yet been reported, when applying the standard method. Two-Dimensional Materials as Prospective Scaffolds for Mixed-Matrix Membrane-Based CO2 Separation.

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A mediation analysis between severity of needs, service performance (adequacy of help, continuity of care and recovery orientation of services) and outcomes (personal recovery and quality of life) was carried out using structural equation modelling. Emphasis is placed on synchrotron X-ray topography and its application in studying various crystal imperfections. Alternative technique for repair of sinus venosus atrial septal defect. In this prospective, nonrandomized study, we present the results of 66 patients undergoing one-stage surgery for obstructed left colon carcinoma. Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells. Melanoma is traditionally considered to be a radioresistant tumor. We found that the apparent volume of distribution could be accurately estimated and an adjusted loading dose calculated, with the use of ideal body weight, degree of underweight, and current use of beta-sympathomimetics. Earlier studies demonstrated that antheridiol binds with high affinity to a 9S multiprotein complex from A. Analgesia was obtained at 0.85 mg/kg with fentanyl and 32 mg/kg with morphine. We evaluated the renal effects of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on top of multifactorial care, including renin-angiotensin-system (RAS)-inhibition.

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The selective role of FXIIa in thrombosis, but not hemostasis, offers an exciting novel strategy for safe anticoagulation based on interference with FXIIa. POCR is generally indicated in patients with signs or symptoms of acute or unstable cardiopulmonary disease. Review of the data on chromosomal rearrangements suggests that several genes along the X chromosomes contribute to ovarian function. We retrospectively reviewed a prospective database to identify 67 consecutive patients who underwent VATS lobectomy for lung cancer by a single surgeon. Comparison of Biologic Disease-Modifying Antirheumatic Drug Therapy Persistence Between Biologics Among Rheumatoid Arthritis Patients Switching from Another Biologic. It is able to reduce the interchain disulfide bridges of murine pentameric IgM and porcin insulin and also to activate vegetal NADP-malate dehydrogenase. Comparative Influence of Sport Type on Outcome After Anterior Cruciate Ligament Reconstruction at Minimum 2-Year Follow-up. Strikingly, preventing the HKII interaction with albenza cost at rite aid mitochondria using exogenous peptides triggers apoptosis of infected cells as does inhibiting either PDPK1 or MYC, which also disrupts intracellular development of Chlamydia trachomatis. Examples are given where various data sources and methods have been applied.

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Global access to opioid agonist therapy and HIV treatment is expanding but when concurrently used, problematic pharmacokinetic drug interactions can occur. SEARCH for Diabetes in Youth is a multicenter study of diabetes in youth. With the arrival of the era of Internet of Things (IoT), Wi-Fi Direct is becoming an emerging wireless technology that allows one to communicate through a direct connection between the mobile devices anytime, anywhere. The tumor recurred in the retroperitoneum and was removed, and postoperative radiation therapy was administered. It is essential to identify these variations in normal anatomy so that appropriate treatment can be initiated to address the anomaly. This study aimed to determine the impact of obstructive sleep apnoea (OSA) on quality of life (QOL) and evaluate the utility of polysomnographic parameters in reflecting QOL. Our analysis reveals a complex and specific expression pattern in these lines, paving the way to an identification of different NB-cell populations by means of specific HOX gene expression schemes. Intensive psychiatric community care thus has beneficial, but somewhat different, outcome profiles at different types of hospitals. Precision Construction of 2D Heteropore Covalent Organic Frameworks by a Multiple-Linking-Site Strategy. In clinical work receptor assays have had limited use until now.

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Treatment of fracture in cattle--an experimental and clinical study. We conclude that 6-keto prostaglandin F1 alpha in peritoneal fluid is not associated with macroscopically visible endometriosis. This is a retrospective review of 150 C2 pedicle screw placements. The available crystal structures suggest that at any given time the RNA/DNA substrate interacts with only one active site of the two domains of HIV-1 RT. Together, our findings have identified the role and mechanism of miR-106b in negatively regulating osteogenesis. CSF leukocyte subpopulations and cytokine levels significantly improve with optimized IL-1 blocking treatment, but do not normalize. Use of a fixed dose of vinorelbine with modifications guided by pretreatment measures is worthy of prospective evaluation. The results of our phylogenetic analyses indicate that Rhynchocalamus is a member of the Western Palearctic clade of Colubrinae and is sister to Lytorhynchus, with which it forms a very well supported clade and shares some morphological characters. Genetic characteristics of echovirus type 9 strains: selection and characterization of variants.

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