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Bonestat (Calcitriol)

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Bonestat is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Admax, Alfarich, Alphadol, Apcical, Aristrol, Biocal, Calasto, Calbovic, Calcicare, Calcigra, Calcikind, Calcimet, Caldikind, Caldix, Calzem, Duracal, Fovit, Lctrol, Netxod, Osteobel, Ostonex, Ostriol, Primacal, Qpcal, Roical, Rolsical, Sorvate, Vezocal

Similar Products:
Lodine, Imodium, Noroxin, Dramamine, Viramune, Anafranil, Depakote, Aldactone, Prevacid, Kelvin, Lamisil, Ximocef, Orapaste, Prohair, Histanit, Levogen, Alangel, Zelet, Etosafe,

Also known as: Calcitriol


Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.


Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.


If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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Renal artery stenosis and left ventricular hypertrophy: an updated review and meta-analysis of echocardiographic studies. CHM combined with routine treatment was more effective in increasing serum estradiol levels and reducing progesterone levels than routine treatment alone. Reuse of the fly ash from the municipal solid waste incinerator (MSWI) is a policy of Taiwan EPA. The type of serum used as growth medium supplement did not affect statistically the fertilization or pregnancy rate. The literature search, selection and assessment of the methodological quality of the studies, and the data extraction were performed according to the standard methodology of the Cochrane reviews. Results Decision trees gave better accuracy and specificity than did discriminant analysis. To investigate the induction of antitumor immune response and therapeutic effects of the vaccination with the fused cells between tumor cells and GM-CSF gene -modified dendritic cells. At the same stage, M2 expression also occurred in part of the dorsal diencephalon adjacent to the M2-positive telencephalic region, with caudal extension along the dorsal midline, and in the zona limitans intrathalamica. Experimental results involving cities in China and India show that our proposed framework is effective.

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Differential expression patterns and intracellular signaling pathways of each receptor enable S1P to exert its widespread functions. Statins have been suggested to have a protective effect on venous thromboembolism (which includes deep vein thrombosis and pulmonary embolism), but the evidence is uncertain. However, no standardized form exists in the Armed Forces Medical Services to document initial nursing observations while a patient is being admitted in service hospitals. To investigate the molecular basis of inherited retinal dysplasia in miniature Schnauzers. Analgesia and Sedation Requirements in Mechanically Ventilated Trauma Patients With Acute, Preinjury Use of Cocaine and/or Amphetamines. Observational cohort study of adult patients who had an in-hospital cardiac arrest from January 2000 through December 2014 included in the Get With The Guidelines-Resuscitation registry, a US-based multicenter registry of in-hospital cardiac arrest.

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Many cellular responses are initiated by the binding of an extracellular ligand to receptors at the cell surface. We conducted a case-control study using patient data collected by the Intracranial Hypertension Registry. Research on attitudes about senility in other cultures shows that this is not the only way to conceptualize cognitive change in later life. The aim was to retrospectively analyze if this buffering reduced toxicity and complication rates. LNI and/or LN progression is a rare entity in patients with localized RCC. We have cloned a cDNA for the 12.3kDa polypeptide (light chain 3) and found that this protein is highly homologous to mouse Tctex1, a protein encoded by a member of the multigene family in the t complex region that is involved in male sterility and the development of the germ cells. Effects of thyroid hormones on the multiple molecular forms of mitochondrial malate-dehydrogenase. Furthermore, using the collected data, we developed a physical model to formularize the correlation between diaphragmatic ROS release and time after irradiation, which can be used to predict the biological effects of radiation with a specific dosage.

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Congenital non-progressive myopathy with central axis (central core disease). Most of these symptoms were transient, and no seizures or psychotic reactions occurred. Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression were also significantly reduced. We calculate this for alternative theories of gravity and find that it is always significantly larger than the general relativity prediction. The purification procedure involved ammonium sulfate precipitation followed by chromatography on an anion exchange column. Shoulder impingement syndrome is a general term used to describe multiple underlying lesions and relatively uncommon in young athletes. The clinical observation that we report has the merit of showing the reality of an allergy that is dependent on plasma filler products due to development of a protocol which includes firstly, during anaphylactic shock, measurement of the mediators of immediate hypersensitivity and secondly, after the clinical accident, test of the activation of basophils by flow cytometry (TAB) and measurement of leucotrienes.

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Experimental results and comparisons against other methods indicate that our proposed snakes model owns better ability in terms of infrared image segmentation than other snakes models. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor. Inflammatory Dermatopathology for General Surgical Pathologists. Using whole-cell recording and calcium imaging in rat slices, we find that dendritic voltage-gated sodium channels allow somatic action potentials to activate voltage-gated calcium channels (VGCCs) along the entire dendritic length, with R-type and T-type VGCCs preferentially located distally. On the other hand, electrical and electronic engineers include piezoelectric sensors in electrical circuits to build devices and need electrical models of the sensor element. Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. The endothelium-mediated forearm blood flow response is obtained by the infusion of acetylcholine into the brachial artery, whereas infusion of sodium-nitroprusside provides information about the endothelium-independent vasodilator capacity of the forearm resistance vasculature. Disadvantage does not seem to have pervasive negative effects on quitting. A 260 bp sequence containing exon 3 was amplified using the polymerase chain reaction, and the variant was found to possess a Bsm I cleavage site not present in normal transthyretin. A population of some 35 intersegmental interneurones with somata in the metathoracic ganglion has been characterized by intracellular recording and staining.

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Breast Cancer and Deodorants/Antiperspirants: a Systematic Review. Seven nomenclatural novelties in Penstemon (Plantaginaceae) are proposed for taxa that will be included in the forthcoming treatment of the genus in the Flora of North America North of Mexico series. The optical density is a linear function of dose up to 2500 Gy and then sublinear for the 5.0 eV band, and for the 4.0 eV band it is sublinear with a filling constant of 2.1 x 10(-4) and 6.2 x 10(-4) Gy(-1). Nevertheless, the literature on cerebrovascular disease in this population is scarce and contradictory. This study analyzes the association of infarct size with the diastolic filling pattern and the evolution of the latter during the first postinfarction year. After a live birth, interpregnancy intervals less than two years do not increase the risk of a pregnancy loss. In the etiology a self-protection mechanism of the CNS with the maintenance of higher glucose concentrations in the brain appears to play a central role. This neuronal filling is blocked by prior pretreatment by administration of Bromodeoxyuridine (BrdU) on embryonic day 13. The results of four experiments indicated, however, that the most general version of this assumption is incorrect. Corneal drug penetration was evaluated over 240 min using the isolated pigmented rabbit cornea in the modified Ussing chamber.

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Staphylococcal Enterotoxin Type R Pseudogene Presence in Staphylococcus aureus Reference and Outbreak Strains. Cochrane Review Summary: Interventions to improve return to work in depressed people. Effect of products of enzymatic transformation of monoamines on cell division (experiments on fertilized eggs of sea urchins). Targeting to these compartments is dependent upon recognition of leucine-based endo. Stress tolerance is a key attribute that must be considered when using yeast cells for industrial applications. The Aging Surgeon: Implications for the Workforce, the Surgeon, and the Patient. Glutathione-dependent and ketone body-related enzymes in the selenium-deficient rat. This study aimed to evaluate the prognostic value of F-FDG uptake of portal vein tumor thrombosis (PVTT) for predicting progression-free survival (PFS) and overall survival (OS) in patients with locally advanced hepatocellular carcinoma (HCC). Many hospitals and physicians in Colorado were unwilling to perform abortions. Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults.

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A study of the necrotic actions of the venom of the wolf spider, Lycosa godeffroyi, on mouse skin. We evaluated the expression of XPO-1 in human prostate cancer tissues and cell lines. Intracranial cavernous malformations - natural history and management. Interferon (induction, characteristics, localization, action and significance). Canine intervertebral disk disease: characterization by age, sex, breed, and anatomic site of involvement. The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small-cell lung cancer (SCLC).

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The following electronic databases were searched: PMedline, PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Evidence Based Medicine Reviews, VIP, and CNKI. A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes. Improved Antifouling Properties of Polydimethylsiloxane Films via Formation of Polysiloxane/Polyzwitterion Interpenetrating Networks. The modified piggyback (cavaplasty) technique could prevent the incidence of venae cavae complications effectively. T-tube placement though oesophageal defects can prove to be an effective treatment option to repair both iatrogenic and penetrating injuries of the Oesophagus, whether early or lopressor 25 mg image delayed.

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This suggests that these selected endophytes produce a compound that is toxic to horses, although the toxic principle is currently unknown. This oversight may be compounded by observation of asymptomatic disc protrusions on computed tomographic and magnetic resonance studies. We have placed this lacZ sequence behind the bovine growth hormone (BGH) gene and found that the lacZ product beta-galactosidase synthesized reflects the level of BGH-specific mRNA. In subjects with knee pain, GCQID supplementation was effective for relieving knee pain and improving locomotor functions. In-Plant Protection against Helicoverpa armigera by Production of Long hpRNA in Chloroplasts.

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Acute tolerance in morphine analgesia: continuous infusion and single injection in rats. Whereas the mechanisms orchestrating the formation of these organs are becoming better understood, their impact on atherosclerosis progression remains unclear. Effects of the Mg ion on the ADP respiratory control of the brain mitochondria and on the oxidation-reduction of intramitochondrial PN (pyridine nucleotide). Class I HLA antigens were detected in a larger number of lesions than HLA-DR antigens, which had a significantly higher frequency than HLA-DQ antigens. A sedimentation equilibrium study of platypus insulin: the HB10D mutant does not associate beyond dimer. This study evaluated the cytokine levels in unilateral tear samples from both sides in patients with pediatric lacrimal duct obstruction. Seroprevalence of bluetongue virus antibodies in sheep and goats in Kerala State, India.

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Compared to repair-proficient CHO 10B cells, a reduction was observed in the overall BrdU-mediated radiosensitization in plateau-phase xrs-5 cells for the same degree of thymidine replacement. The current study was designed to two objectives: 1) to analyze the reliability and validity the BDI-II among Korean adolescents and 2) to evaluate the factorial structure in a Korean nonclinical adolescent sample. After ursodeoxycholate administration, both the maximum concentration of cefotiam in the bile and the amount excreted increased significantly. Custom fabricated pressure probes were used to determine the pressure in front of the optical fiber in a small dish and patch pipettes to measure temperature changes. Four further segments were chosen for HRV determination, namely, a 4-h segment from midnight to 4 AM and three 5-min segments: 1 just before awakening, 1 after waking in supine position, and 1 in standing after orthostatic challenge. This is suggestive of a persisting abnormal alpha2-adrenoceptor function in forebrain regions after recovery from an episode of endogenous depression, and may represent a trait marker for this condition.

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Cotton-Dam Wash Cytology:A Technique for Diagnosis and Prevention of Dissemination during Resection of Metastatic Brain Tumors. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. The prilosec generic name omeprazole presence of the PALB2 duplication in the proband affected with high-grade serous ovarian cancer suggests that PALB2 might be associated with a predisposition to ovarian cancer. Agonistic behaviour related to territorial defence is likely to be costly in terms of energy loss and risk of injury. Translocation of Radioactive Isotopes from Various Regions of Roots of Barley Seedlings. Assemblages of metazoan ectoparasites of 79 species and gastrointestinal helminths of eight species of marine fishes were analysed to examine whether nestedness is related to sample size, abundance, species richness, and prevalence of infection, and whether the use of z-scores or Monte Carlo simulations yields different results. Age as a single variable may provide equivalent discriminatory power for operative mortality as the established risk models.

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A QAB disinfectant product is more effective at removing surfactant than a CLB disinfectant product. Bilateral diaphragmatic paresis following pediatric liver transplantation. Comparative effects of prolonged therapy with four calcium ion antagonists (diltiazem, nicardipine, tiapamil and verapamil) in patients with chronic stable angina pectoris. Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy. Results Restriction digestion and DNA sequencing revealed that the eukaryotic expression plasmid of pEGFP-N2-FMR1 was successfully constructed. MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas.

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L69V exhibited 100-fold faster hydrolysis of DFP than the wild-type. Enhanced CDX2 promoter methylation is associated with gene silencing in a subgroup of colorectal cancer patients with lymph node metastasis and shorter survival times. Incorporation of P 32 into various types of mitochondrial, nuclear and cytoplasmic RNA. We report a case of a 4-year-old boy with bilateral renal lesions resembling nephroblastic rests as the first finding of early stage ALL preceding hematological changes and subsequent classic clinical findings by two weeks. Small interfering RNA (siRNA) is an effective tool to silence gene expression post-transcriptionally. Next, filtering operators, using inter-structure relational knowledge, are used in order to find the winner tuple. It has been found that neonatal thymectomy substantially eliminates both PHA reactivity and responsiveness to alloantigens assayed in vitro in host spleen cell populations. what drug class is vasotec In particular, cells respond to nanoscale physical properties of their matrix. Effects of oxygen and carbon monoxide on the intermediate steps of estrogen biosynthesis. and thymidine treatments may be due to thymidine-induced nucleotide pool imbalance with consequent inaccuracies in DNA repair.

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If this approach is found to be effective, it will offer a low-cost, simple method for reducing the personal and societal burdens of LBP. Image Gallery: Cutaneous botryomycosis at an unusual site in an immunocompetent patient. Biochemical laboratory results were retrieved from biochemistry laboratory database while age and sex of patients were retrieved from patient files. Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses. Herein, we apply LC-UVPD-MS methods to analyze post-translational modification along native sequence CTDs. This study aims at bridging this gap with a combined experimental and computational effort. Cold storage of the canine pancreas prior to islet cell preparation and transplantation. We evaluated technical success, safety, initial response rate, progression-free survival (PFS), and overall survival (OS).

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Comparisons of lactate dehydrogenase isoenzymes with human prostatic cancer. Neither DNA damage-responsive pathways nor Pds1/securin are needed for this checkpoint. This mutation activates adenylate cyclase and consequently increases intracellular concentrations of cAMP. The explants included 6 glioblastomas, 4 anaplastic astrocytomas, 5 astrocytomas, 3 ependymal tumors, 2 meningiomas, 1 medulloblastoma. Patients with a diagnosis of acquired brain injury and tracheostomy in situ were included in this study. A familial case of fibrodysplasia ossificans progressiva (myositis ossificans progressiva). This is problematic as latency-reactivating agent-based HIV-1 eradication trials utilize changes in viral transcription as an efficacy biomarker. This results in accurate genome-wide p-value estimates for a wide range of large thresholds with a substantially smaller cost adjusted relative efficiency with respect to standard unweighted simulation.

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Quantitative Analysis of Ingenol in Euphorbia species via Validated Isotope Dilution Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry. In vitro kinase reaction assays revealed that receptor heterodimerization is induced by EGF binding and leads to a dramatic increase in the self-phosphorylation capacity of the dimerized receptors. Parallel shifts of CAP amplitude- and latency-intensity functions were observed. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major pathogens of HFMD. Patients were commenced on aflibercept injections in 1 or both eyes from October 1, 2013 to December 31, 2013. Concern for dependants may be an cyproheptadine periactin medicine important focus for suicide prevention in clinical practice. The aim of this study was to evaluate the prognostic factors and out comes in patients with ovarian carcinosarcoma.

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All of the MR imaging findings were confirmed at surgical biopsy. In vitro effects of toxaphene on mitochondrial calcium ATPase and calcium uptake in selected rat tissues. There is substantial, but not complete, overlap between the genetic factors that influence individual variation in neuroticism and those that increase liability across the internalizing disorders, helping to explain the high rates of comorbidity among the latter. Serum lipids, skin-fold thickness, body bulk, and body weight of native Cape Verdeans, New England Cape Verdeans, and United States factory workers. This work follows our previous studies in which we validated the ability of ONIOM to compute accurate transition energies compared to EOM-CCSD. Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. The success of this approach relies on the use of hydrochloric acid (HCl) to control the reduction rate, and on the presence of bromide ions (Br(-)) to selectively adsorb on certain facets of the PdCu nucleus. Age disorientation in chronic schizophrenia is not associated with pre-morbid intellectual impairment or past physical treatment. Results of culture and toxin, prior antibiotic use, antibiotic treatment history and cost were analyzed. The best strains accumulated 0.37g/l 2-methyl-1-butanol and 2.76g/l 3-methyl-1-butanol in defined medium within 48h under oxygen deprivation conditions, making these strains ideal candidates for additional strain and process optimization.

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