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Bolodol (Tramadol)

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Bolodol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Bolodol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Acupain, Admadol, Anazac, Arodol, Arrestadol, Damadol, Dolfre, Esgiypyrin, Gemodol, Hyperdol, Inodol, Kevtram, Leedol, Movon, Muzox, Neutram, Nopidol, Ospidol, Painex, Rimol, Ryzolt, Sedate, Soztram, Tandam, Taramol, Tramafen, Tramakind, Tramatas, Tramot, Trazac, Tremtec, Trugesic, Trydol, Urogendo, Veeradol, Victadol, Zamadol, Zotadol

Similar Products:
Xanax, Maxolon, Zudena, Symmetrel, Atarax, Omnicef, Theolair, Diovan, Clonix, Cidazole, Tensaar, Spinospas, Itral,

Also known as: Tramadol


Bolodol (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Bolodol is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Bolodol ER) is for around-the-clock treatment of pain. Bolodol ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Bolodol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Bolodol ER.

Never share Bolodol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Bolodol ER.

Bolodol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Bolodol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Bolodol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Bolodol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Bolodol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Bolodol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Bolodol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Bolodol should not be given to a child younger than 12 years old. Bolodol ER should not be given to anyone younger than 18 years old.

Do not give Bolodol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Bolodol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Bolodol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Inhibition of PKR expression significantly prevents RABV-SG formation and favors viral replication by increasing viral translation. They have gradually become important issues in the course of preventive medicine. Serious somatic disease is rare in patients complaining of tiredness. In addition, the presence of an audible cracking sound during manipulation, especially on external rotation, was associated with better shoulder range of motion. A pilot study on the prevalence of DNA palindromes in breast cancer genomes. In the presence of lanthanum contractions evoked by oxytocin, but not PGF, were augmented 2-3-fold. The recent activity relating to the development of nursing informatics competencies for beginning level nurses has exposed a paucity of understanding of the requirements for nursing informatics competencies for nurse educators.

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Findings show that individuals who practice Tai Chi report a variety of immediate and lasting physical and mental benefits. The axonal pathway, soma, and dendritic distribution of each labeled motor neuron was traced in the thoracic ganglion, and their relative positions were determined. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Homogeneous immunoassay based on dihexadecyl-dimethylammonium bilayer membranes. Unlike other retroviral envelope proteins, however, gp160 also forms a secondary association with the lipid bilayer mediated by one or more regions located in the cytoplasmic tail. Introduction to the special section: Philosophy and personality disorders. Antibody levels were highest among animals immunized during the dark phase of their cycle for both control and shocked animals.

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We confirm that the contribution of suction distance is limited even in this phylogenetically and ecologically broad sample of species, with the extreme suction area of prey-capture space conspicuously unoccupied. These and other data indicate that NM2A filaments are partitioned by the dynamic movements of actin fibres to which they are bound. Various methods have been described for the treatment of the acutely infected total knee arthroplasty. Molecular epidemiology of hepatitis C virus and its relation with persistence or clearance of infection in Hamadan, West-Iran. This review aims to present a thorough discussion of the available evidence-based data which support the use of garlic in the treatment or prevention of cardiovascular diseases, including atherosclerosis, hypertension, and hyperlipidemia. Each group was asked to complete an instrument that assesses perceived social support (Headache Social Support Questionnaire), medication attitudes (Beliefs about Medicines Questionnaire), locus of control (Headache-Specific Locus of Control Scale), and migraine-associated disability (Migraine Disability Assessment Questionnaire). Effect of Topical Morphine on Acute and Chronic Postmastectomy Pain: What Is the Optimum Dose?. Opening of the corneal surface with a flap and use of an excimer laser is no longer necessary. With a single or repeated drug dose complete muscular relaxation could be assured during operation of 25-60-minute duration. Magnolin is the most active ingredient in the herb Magnolia fargesii, which has been traditionally used in oriental medicine to treat headaches and nasal congestion.

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Prevalence rates of overweight and obesity were calculated and logistic regression models, adjusting for confounders, were used to examine the relationship between social class, effects of the recession and childhood obesity. Both sporulation and protease production can be inhibited by growing Bacillus cereus T in a medium containing a high concentration of a mixture of amino acids. Changes in PGE2 urinary excretion and renal function in coronary heart disease. Quantitative in vivo measurements are essential for developing a predictive understanding of cellular behavior. The simulations employed recently derived optical response functions for square-symmetric molecules with doubly degenerate excited states.

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Aortic intramural hematoma is an acute aortic syndrome caused by hemorrhage within the aortic wall and characterized by the absence of an intimal tear and false lumen, which are the main features of classic aortic dissection. Additionally, prior studies have been limited by the fact that HVIP typically rely on self-report or data within their own healthcare system to identify new injuries. The increased failure rate in MoM hip arthroplasty is associated with the generation of biologically active, nanometer sized metal particles from the MoM bearing surfaces and taper junctions, which result in the development of a localized, adverse periprosthetic soft tissue response. Sequence-specific assignments were obtained from sequential nuclear Overhauser enhancement (NOE) connectivities. However, whether steatosis per se promotes liver cancer, and the molecular mechanisms that control the progression in this disease spectrum remain largely elusive.

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These inter-laboratory comparisons demonstrate that the local lymph node assay is a robust and reliable method for the identification of at least moderate and strong contact allergens. There were no examples in any recommendations of RCTs with direct evidence of improved health outcomes. Patients with cervical Ureaplasma Urealyticum and Chlamydia Trachomatis infection undergoing IVF/ICSI-ET: The need for new paradigm. Thus, in the study of valuation related to changes in pesticide use, much attention should be devoted to the design and definition of the context. The surgical management of the N0 neck should therefore not be based on PET/CT findings alone. This injury, although rare in the general population, is seen more commonly in rock climbers. Medical Case Management for Victims of Terror: A Report From Jerusalem. Single photoreceptor cells in the compound eye were impaled, identified by spectral response, and marked with dye-filled microelectrodes. The differences between the histochemical pattern of untreated corneas or corneas treated with some serine protease inhibitors are shown, and the efficacy of these drugs is discussed in light of present knowledge. In this study we investigated changes of heart rate variability parameters in patients before and after PTCA at different time intervals.

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All-digital frequency synthesis using bandpass sigma-delta modulation to achieve spectrally clean single-bit output is presented and mathematically analyzed resulting in a complete model to predict the stability and output spectrum. The DNA sequence and structural organization of the GC2 plasmid from the red alga Gracilaria chilensis. Remarkably, SIRT1 was confirmed as a direct target of miR-138-5p in cervical cancer and miR-138-5p exerted the tumor suppressed functions by suppressing SIRT1 expression. Paroxysmal atrial fibrillation is generally triggered by a PAC, with left atrial origin in two-thirds of cases: CI and neuroendocrine balance are factors affecting the induction of the arrhythmia. The aim of this study was to investigate whether CT can replace SL in the detection of PM. A radioimmunological method is presented for the determination of the quantity of prostaglandin F2 alpha in cut wounds on the skin of guinea pigs. These findings do not support the use of improvisational music therapy for symptom reduction in children with autism spectrum disorder.

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There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Community structure of both communities were assessed via comparisons of morphospecies abundance, diversity, and composition. This lead to the discovery that activin A is a second renal repair factor circulating in increased levels during CKD. The large surface to area ratio inherent in these materials also allows easy functionalization and maximal interaction with the external environment. In contrast to most plasma glycoproteins, asialofibrinogen and aglycofibrinogen manifest relatively normal in vivo survivals, suggesting that molecular determinants other than the carbohydrate may be involved in their catabolism. Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.

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Our study show for the first time a significant up-regulation of DNMT3B levels in 14 RMS tumour samples and 4 RMS cell lines in comparison to normal skeletal muscle. Trial Watch: Immunotherapy plus radiation therapy for oncological indications. The primary objective of this study was to compare treatment of ovarian cancer according to age. Health-related quality-of-life (HR-QOL) may be affected by various factors including injury-related characteristics among individuals with spinal cord injury (SCI). The antibodies used for staining were GABA, GFAP, GAD, and vimentin. Fludarabine has shown encouraging results in these patients and deserves further investigation in combination with other active agents, and in the setting of front-line therapy. We develop a comprehensive supervised learning algorithm to address these issues. Alexander technique in the treatment of stuttering-- a randomized single-case intervention study with ambulatory monitoring. Here, by tracking objective performance (accuracy) and subjective experience (ratings of target visibility and choice confidence) over time and in a large sample of participants, we demonstrate the coexistence of transient and sustained effects of mixing easy trials, which differ markedly in their timescales, in their effects on subjective awareness, and in individual differences.

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Localization and biosynthesis of functional thrombomodulin in human megakaryocytes and a human megakaryoblastic cell line (MEG-01). Growing concern on the increase of antimicrobial resistance force a more rational use of antibiotics and this can be achieved through a correct understanding of the issues related to antibiotic therapy and to the use of antibiotics by both practitioners and farmers. Angiectasias, hamartomas, and vascular neoplasms of the skeleton (angiomas, hemangioendotheliomas, hemangiosarcomas). Some PNPLA2 mutations, such as the one described here, may present with an extended phenotype, including brain involvement. Lung cancer deaths in the United States from 1979 to 1992: an analysis using multiple-cause mortality data. Radiologic and serological investigations attributed her symptoms to bilateral, large echinococcal cysts. The standardised mortality rates (SMR) were higher particularly above 50years of age among most migrant groups compared with native born Danes, and with a higher annual increase. Hyperplastic endometrial processes in patients with albenza dosage pinworms postpartum obesity and disordered menstrual function. We performed this study to determine the contribution of the proinflammatory cytokines to the generalized seizure activity during adenosine and caffeine treatment. Conceptual model, burden of administration, feasibility, reliability, criteria validity and construct validity were assessed.

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PLP 139-151-sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. Modulators of Pgp-MDR are without effect in cells expressing only at-MDR. The survival curve of cells photosensitized to white light by this dye has a pronounced shoulder followed by an exponential decline. Sciatic nerves in rats were given crush injury, and BYHWD was injected by oral administration. Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disease secondary to platelet aggregation. The addition of 100 microM glutamate to the does generic zyrtec work the same culture medium resulted in an increase in GS mRNA in the astrocyte cultures similar to that observed in the cocultures, where the addition of glutamate did not further increase GS mRNA levels. Application of 5 micrograms/ml verapamil, a calcium channels blocking agent, abolished the noticed effect of the venom.

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However, this treatment alone is insufficient to prevent progressive anterior stromal opacification. The golden phenotype segregates as an autosomal recessive, showing no linkage to the sex-linked enzyme marker glucose-6-phosphate dehydrogenase. N-Myristoyltransferase (NMT) catalyzes the transfer of myristate to the amino-terminal glycine of a subset of proteins, a co-translational modification involved in trafficking substrate proteins to membrane locations, stabilization and protein-protein interactions. Throughout the dormancy period, development of intratumoral vessels is impaired. Cardiovascular disease in familial hypercholesterolemia: Validation and refinement of the Montreal-FH-SCORE. Effect of secretin on gastric motility was studied on the preparation of isolated vascular perfused rat stomach. We hypothesized that the indigenous people of Eastern Uganda have used T. hyopneumoniae were significantly higher in nylon-flocked swabs with Ct differences only ranging from 0.5 to 1.7. When autocrine embryotropins such as insulin-like growth factor-I (IGF-I) or platelet activating factor (PAF) bind to their appropriate receptor, the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway will be activated which is important for embryo survival. Neuromodulatory systems activated by training experiences appear to play a role in influencing memory storage processes.

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A major concern by the health decision makers in Gulf Cooperative Council (GCC) countries is the burden of financing healthcare. The microbial communities found in the sampled marine sediments were studied using PCR- albenza cost at rite aid DGGE (denaturing gradient gel electrophoresis) fingerprinting profiles in combination with multivariate analysis. Manganese superoxide dismutase (MnSOD) is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma. Some evidence leads to a hypothesis that awareness of action selection is not directly causing the action execution (or behaviour) but comes afterwards as an effect of unconscious processes of action preparation. We apply this method to multiple genomic data including the expression profiles of miRNAs, TFs and genes on breast cancer obtained from TCGA, priori miRNA-gene regulations, TF-gene regulations and gene-gene interactions.

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We investigated the possible effects of three pedicular screws on axial pull-out strength in pedicular revision surgery. Study protocol: pragmatic randomized control trial of an internet-based intervention (My tools 4 care) for family carers. He was treated with anticoagulant therapy combined with antiplatelet therapy, and his symptoms were quickly resolved. Polyamino acid derivatives of mammalian cytochrome c undecapeptide. Fibrovascular incorporation into surrounding tissues and implant remodeling reduce the risks associated with a persistent foreign body, such as chronic infection, enterocutaneous fistulae, and cutaneous exposure. Restoration of thalamo-cortical connectivity after brain injury: recovery of consciousness, complex behavior, or passage of time?. Additionally, up to 1 in 5 individuals prescribed an antidepressant may not be adherent, suggesting the need for further efforts to reduce treatment nonadherence.

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Improved Dechlorinating Performance of Upflow Anaerobic Sludge Blanket Reactors by Incorporation of Dehalospirillum multivorans into Granular Sludge. Beside the direct cardiac action with blockade of the cardiotoxic effect of the extremely high levels of plasma catecholamines, induction of an upregulation of the down-regulated beta-1-receptors there is attenuation of the activity of the renin-angiotensin-aldosterone system. Remarks on the classification of Rhabdovirales in the Lwoff, Horne and Tournier viruses classification system. Transparent and open discussion of errors does not increase malpractice risk in trauma patients. Sequence analysis of the remaining clones revealed 99 unique clones corresponding to 69 genes. Problems with resection of lung tissue for residual tubercular lesions following antitubercular treatment in negative findings of Mycobacterium tuberculosis in the sputum. Many transplant recipients who are free of graft-versus-host disease (GVHD) and not receiving any immunosuppression more than 1 year after transplantation seem to be able to mount appropriate immune responses to common pathogens and respond adequately to immunizations what is generic plavix called .

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Addition of new antigens, such as adenylate cyclase, to current vaccines might improve some aspects of the immune response to vaccination, but are unlikely to significantly increase the duration of protection. In particular, the presence of a phenolic function, with a possible H-bond donor role, has been confirmed. Evaluation of Partial Cut-out of Sacroiliac Screws From the Sacral Ala Slope via Pelvic Inlet and Outlet View. The results indicate that the extent to which both paradigms lead to similar conclusions regarding the validity of the surrogate, depends on a complex interplay between multiple factors like the ratio of the between and within trial variability and the unidentifiable correlations between the potential outcomes. The authors investigated the value of this test in 213 women with ovarian carcinoma, benign pelvic masses, benign nongynecologic diseases, and healthy controls. Hyperglycemia is an independent risk factor for increased mortality of critically ill surgical patients, but despite the recognized clinical benefits of early insulin treatment, there is a lack of understanding of the cellular and molecular mechanisms behind this phenomenon. Five milliliters of blood and saliva were collected from both the groups.

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After sequential exposure to simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) for 2h almost complete death of free cells was observed however the numbers of surviving cells were 5.15 and 6.67 Log CFU/g for pectin and pectin/starch hydrogel, respectively. Erratum to: Heparin-binding protein is important for vascular leak in sepsis. Rice and maize are important cereal crops that serve as staple foods, feed, and industrial material in China. The basic postural adjustments are selected on the basis of the spatial parameter, whereas fine tuning of the pattern is guided by temporal and quantitative parameters. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.

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However, the effect escaped statistical significance, most likely because of the small sample size. Disease activity parameters for ankylosing spondylitis and lipid levels (total cholesterol, high-density lipoprotein cholesterol (HDLc) and triglycerides) were measured in 45 patients with ankylosing spondylitis for enalapril target dose 6 months after starting treatment with leflunomide or placebo. The vertebrate phototransduction cascade: amplification and termination mechanisms. Monocyte chemoattractant protein 1 (MCP-1) is known to be an important chemokine for macrophage recruitment. This document reviews-according to the Family Planning Official Norm of the Ministry of Health-those different contractive alternatives, that can be used in the postabortion. Activation of consecutive p53 responses separated by a period of recovery led to the selective attenuation of a subset of p53 regulated mRNAs corresponding to those targeted by one or more of the p53-responsive miRNAs. On the basis of our previous work on DNA fluorophores derived from vinylpyridinium-triphenylamine, we explored the structure space around the electron-rich triphenylamine (TP) core by changing the vinyl bond to an oxazole ring. The results suggested that ketamine and norketamine were unstable in gravity and rising main sewers, ketamine was unstable in bulk liquid while norketamine was stable under the same condition. A pilot study of ultrasound-guided electronic brachytherapy for skin cancer. We show that down-regulation of several genes upstream to Runx2 and Osterix is manifested within the calvarial primordia, including Bmp2 and its downstream genes Msx1/2 and Dlx5 By contrast, we find that Gli1, the Hedgehog activity readout gene, is excessively activated in mesenchyme.

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