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Biproate (Divalproex)

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Biproate is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.

Other names for this medication:
Biproate, Desval, Devot, Dilex, Diproex, Divalex, Divalin, Divalprid, Divalpro, Divalproex, Dixval, Epirate, Epival, Navalin, Nepilex, Proval, Spikalon, Torvate, Trival, Valance, Valate, Valcontin, Valcort, Valcot, Valfox, Valimep, Valop, Valparin, Valpip, Valporate, Valporil, Valporl, Valpret, Valprosh, Valrate, Valric, Valtec, Valtril, Valvo, Velpo, Vinchorate

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Also known as: Divalproex


Biproate is a perfect remedy in struggle against seizure disorders. Biproate acts by increasing the amount of a certain natural substance in the brain. Biproate is also known as Valproate semisodium, Divalproex sodium, Valproic acid, Divaa. It is anticonvulsant. Generic name of Biproate is Divalproex Sodium. Brand names of Biproate are Biproate, Biproate ER, Biproate Sprinkles.


This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Biproate DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Valproic acid dosage information

Side effects

The most common side effects associated with Biproate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Accelerometer sensor module and fall detection monitoring system based on wireless sensor network for e-health applications. The recent advances in genetic studies provide both diagnostic tools and new pathogenetic insights in this rapidly expanding area of human pathology. Common ground and cultural prominence: how conversation reinforces culture. Implications concerning dietary habits of animals is an adjunct consideration in this work. A reproducible membrane-bound configuration emerges from these simulations, despite employing a diverse set of initial configurations. The quantitative EEG method yielded significantly more seizure episodes that were correctly lateralized and there was a trend towards more correctly localized seizures. Municipal waste management: inequities and the role of deliberation. We investigated whether the presence of a high number of uncommon symptoms attenuated the relation between self-reported PTSD symptoms and heart rate variability (HRV).

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