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Bioglita

Bioglita works by making cells more sensitive to insulin, which is used to regulate the level of glucose in the body. Improving insulin sensitivity (or reducing insulin resistance) makes it easier for sugar (glucose) in the blood to get into the cells.

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Also known as: Pioglitazone

Description

Bioglita is a medication that’s used to treat type 2 diabetes. This is a condition in which where your body has a high level of glucose (sugar) in your blood. Your pancreas normally makes a hormone called insulin, which takes glucose out of your blood and helps you use the sugar as a source of energy. With type 2 diabetes, your pancreas may not be making enough insulin to remove the sugar from your blood.

And if you have type 2 diabetes, your cells may also become insulin resistant. This means that your body makes insulin but isn’t responding to it by removing the sugar from your blood. So people with type 2 diabetes have high blood sugar levels.

What Bioglita does

Bioglita works by making your cells more sensitive to insulin. The goal is for your cells to take the glucose in your blood and use it more effectively as an energy source. Because you’re using your glucose more effectively, your blood glucose levels will decrease.

This lowers your risk of serious complications of type 2 diabetes, including heart disease, nerve damage such as neuropathy, and kidney failure.

How long does it take to work?

After you start using Bioglita, it may take 7 days or longer before you notice any changes in your blood glucose level. It’s important to keep taking Bioglita every day so that it can have the best chance to work in your body.

Dosage

Take Bioglita by mouth with a full glass of water with or without food. The initial dose of Bioglita is 15 mg once a day. In case of inadequate glycemic control, the dose can be increased up to 45 mg once daily. If hypoglycemia occurs in a patient co-administering Bioglita and insulin, the dose of insulin should be decreased by 10% to 25%. Further adjustments to the insulin dose should be individualized based on glycemic response. Take the drug at the same time each day. If you want to achieve the most effective results, do not stop taking Bioglita suddenly.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Bioglita overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bioglita are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Bioglita if you are allergic to pioglitazone, or if you have:

severe or uncontrolled heart failure; or diabetic ketoacidosis (call your doctor for treatment).

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

To make sure Bioglita is safe for you, tell your doctor if you have ever had:

congestive heart failure or heart disease; a heart attack or stroke; eye problems caused by diabetes; bladder cancer; or liver disease.

Bioglita may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Bioglita if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Bioglita. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Bioglita is not approved for use by anyone younger than 18 years old.

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Collectively, these results provide insight into effector mechanisms utilized by protective CTL directed against non-traditional cryptic epitopes during disease protection. These results show that adult CNS fibers are able to sprout and to form new synaptic contacts after a lesion when a growth-permissive microenvironment is provided. Concomitant with resistance to weight gain, lack of NPC1L1 or treatment with ezetimibe also conferred protection against diet-induced hyperglycemia and insulin resistance. The observed alterations in protein expression and cytoplasmic-nuclear partitioning of the GR, Hsp90 and Hsp70 proteins may be related to maladaptive response of the HPA axis under chronic stress. Accordingly, in the context of a high-risk population (The Bahamas) for HIV, a 17-item scale--the Condom-use Skills Checklist (CUSC)--was developed for use among young adolescents and adults.

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On top of these dynamic changes that are linked to the course of the disorder, antipsychotics, and especially antipsychotics inducing hyperprolactinaemia, exert additional enlarging effects on pituitary volume. Gastrostomy feeding is commonly used to support patients with amyotrophic lateral sclerosis who develop severe dysphagia. In vitro lipopolysaccharide (LPS) stimulation of PBMCs induced NF-kappa B translocation. The first group wore a silicone mouthguard for 4 months and an acrylic one for the following 4-month period. A shunting procedure employing cannulation of the lumbar theca through the meningocele sac. This newly described phenomenon is interpreted in terms of waveguide modes of a tapered dielectric slab of a mode index, which is known to decrease with slab thickness.

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