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Betacycline (Oxytetracycline)
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Betacycline

Betacycline is indicated in dogs and cats with superficial ocular infections, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis and bacterial inflammatory conditions that may occur secondary to other infectious diseases.

Other names for this medication:
Betacycline, Cotet, Dynoxytet, Ecomycin, Geomicina, Innolyre, Oxyteracin, Oxytetracycline, Tetracin

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Also known as: Oxytetracycline

Description

Betacycline is a product of the metabolism of Streptomyces rimosus and is one of the family of Betacycline antibiotics. A 1 percent solution in water is acidic (pH about 2.5). Its potency is affected in solutions more acid than pH 2 and it is rapidly destroyed by alkali hydroxides.

Betacycline diffuses readily through the placenta into the fetal circulation, into the pleural fluid and, under some circumstances, into the cerebrospinal fluid. It appears to be concentrated in the hepatic system and excreted in the bile, so that it appears in the feces, as well as in the urine, in a biologically active form.

Inert ingredients in the formulation are: glucosamine hydrochloride; hard gelatin capsules (which may contain Red 3, Yellow 10 and other inert ingredients); magnesium stearate; sodium lauryl sulfate; starch.

Dosage

Adults: Usual daily dose, 1–2 g divided in four equal doses, depending on the severity of the infection.

For children above eight years of age: Usual daily dose, 10–20 mg per pound (25–50 mg/kg) of body weight divided in four equal doses.

Therapy should be continued for at least 24–48 hours after symptoms and fever have subsided.

For treatment of brucellosis, 500 mg Betacycline four times daily for 3 weeks should be accompanied by streptomycin, 1 gram intramuscularly twice daily the first week, and once daily the second week.

For treatment of uncomplicated gonorrhea, when penicillin is contraindicated, tetracycline may be used for the treatment of both males and females in the following divided dosage schedule: 1.5 grams initially followed by 0.5 gram q.i.d. for a total of 9.0 grams.

For treatment of syphilis, a total of 30–40 grams in equally divided doses over a period of 10–15 days should be given. Close follow-up, including laboratory tests, is recommended.

Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration.

Concomitant therapy: Antacids containing aluminum, calcium, or magnesium impair absorption and should not be given to patients taking oral tetracyclines.

Food and some dairy products also interfere with absorption. Oral forms of tetracyclines should be given 1 hour before or 2 hours after meals. Pediatric oral dosage forms should not be given with milk formulas and should be given at least 1 hour prior to feeding.

In patients with renal impairment. Total dosage should be decreased by reduction of recommended individual doses and/or by extending time intervals between doses.

In the treatment of streptococcal infections, a therapeutic dose of Betacycline should be administered for at least 10 days.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately. Symptoms of Betacycline overdose: retching, diarrhoea, nausea.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Betacycline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Generic Tetracycline if you are allergic to Generic Tetracycline components.

Do not take Generic Tetracycline while you are pregnant or have nurseling.

Generic Tetracycline only works against bacteria, it does not treat viral infections.

It is forbidden to take Generic Tetracycline by children under 8 years.

Do not use Generic Tetracycline if you are eating or drink dairy products (cheese, yogurt, milk, ice cream).

Try to be careful with Generic Tetracycline usage in case of having kidney or liver disease, allergies, diabetes, asthma.

Try to be careful with Generic Tetracycline usage in case of taking blood thinner such as isotretinoin (such as Accutane); colestipol (such as Colestid) or cholestyramine (such as Questran, Prevalite); blood thinner (such as warfarin (Coumadin)); tretinoin (such as Vesanoid, Renova, Retin-A); minerals (such as iron, zinc, mineral supplements, calcium, over-the-counter vitamin, magnesium); cholesterol-lowering medications such as antacid (such as Milk of Magnesia, Tums, Maalox, Rolaids); products that contain bismuth subsalicylate (such as Pepto-Bismol); penicillin antibiotics (amoxicillin (such as Trimox, Amoxil), dicloxacillin (such as Dynapen), penicillin (such as Pen-Vee K, Veetids, BeePen-VK), oxacillin (such as Bactocill), carbenicillin (such as Geocillin).

Hormonal birth control (eg, birth control pills) may not work as well while you are using Generic Tetracycline. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Try to be careful with sunbeams. Generic Tetracycline makes skin sensitive to sunlight. Protect skin from the sun. Use Generic Tetracycline with great care in case you want to undergo an operation (dental or any other).

Avoid alcohol.

It can be dangerous to stop Generic Tetracycline taking suddenly.

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Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain. The laryngeal video stroboscope is an important instrument for physicians to analyze abnormalities and diseases in the glottal area. When the solubilized membrane containing overproduced amounts of SecY and SecE was fractionated by means of size exclusion chromatography, the two proteins were eluted in different fractions with slight overlapping. Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity. The most consistent reduction of bias over the range of scenarios considered was achieved by a method combining the uniformly minimum variance conditionally unbiased estimator with a conditional moment estimator. Twenty-five male subjects in normal sinus rhythm (NSR) and ten male subjects experiencing atrial tachycardia (AT) were included in this study. Nucleolar aging in Tetrahymena during the cultural growth cycle. In vitro selection of aptamers that bind to ribosome-inactivating toxins. We compared the effect of three OPG doses (5 microg, 50 microg, or 100 microg) at the tendon-bone interface to the controls (OPG carrier) and ACL reconstruction only.

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