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Baclof (Baclofen)

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Baclof is not FDA-approved for back pain, but providers will often prescribe it for this as well as other types of pain. This is considered an "off-label" use of Baclof. It might work for you if your back pain is caused by muscle spasms. If your pain is dull and achey or feels like pins and needles, it might not help much.

Other names for this medication:
Bacfen, Baclof, Baclofen, Bacmax, Chinofen, Liofen, Parafon, Riclofen, Spinofen, Spinospas, Tefsole

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Also known as: Baclofen


Intrathecal baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, cerebral palsy, or certain injuries to the spine. Intrathecal baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Intrathecal baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects.

This medicine is delivered by a drug pump directly into the spinal fluid of your back. A doctor will surgically place the pump and monitor the dose of the medication that is delivered by the pump. The dose of intrathecal baclofen will be different for different patients and will depend on the type of muscle tightness that you have.

Intrathecal baclofen is given only by or under the direct supervision of a doctor.


This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Baclof. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation: For oral dosage form (solution): Adults and children 12 years of age and older—At first, 5 milliliters (mL) three times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day). Children younger than 12 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.


If you overdose Generic Baclof and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze.

Detailed Baclof dosage information

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The most common side effects associated with Baclof are:

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Quantitation of group-specific a antigen in hepatitis B vaccines by anti-HBs/a monoclonal antibody. Covalent linking of the conjugated polyelectrolyte moiety into the microgel prevents leakage of the fluorophore while keeping its fluorescence property. S-nitrosoglutathione and sodium nitroprus-side were used as NO donors and H. Comparative effects of University of Wisconsin and Euro-Collins solutions on pulmonary mitochondrial function after ischemia and reperfusion. A multi-institutional, retrospective cohort of 70 patients 45 years of age and under with head and neck squamous cell carcinoma (SCC) presenting over an 11-year period was studied. These adducts include HNE-His Michael adducts (MA), ONE-Lys 4-ketoamide, ONE-Lys pyrrolinone, and a Cys/His-ONE-Lys pyrrole cross-link. In this study, the stimulatory effects of B7RP-1 on cellular and humoral immune responses were investigated giving mice a construct with the extracellular domain of murine B7RP-1 fused with human IgG1 Fc (B7RP-1-Fc). Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder. In reported cases where aortic dissection has been missed, clinician awareness of the disease was not the primary issue but failure to respond to clinical cues suggestive of aortic dissection was.

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As a consequence, HDL prevented activation of caspases 9 and 3 and apoptotic alterations of the plasma membrane such as increase of permeability and translocation of phosphatidylserine. Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways. Oximetry fails to predict acute mountain sickness or summit success during a rapid ascent to 5640 meters. Developing interventions for chronically ill patients: is coping a where can i buy feldene helpful concept?. Nitrosobenzene-mediated C-C bond cleavage reactions and spectral observation of an oxazetidin-4-one ring system. Conversely, the improvement in race time was directly related to the race distance. Pathological features showed an extensive inflammatory cell infiltration, with predominantly eosinophilic cells throughout the submucosa. Fetal growth is positively affected by maternal BMI during pregnancy. A series of 2-(arylmethyl)pyridoisothiazolones is reported that inhibit the IL-1 beta induced breakdown of bovine nasal septum cartilage in an organ culture assay.

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In this overview and the associated reviews, the behavioral, genetic and neural factors that promote over-eating in animals and humans are discussed. The aim of this study was to analyze lymphocyte infiltration using immunohistochemistry in proliferative diabetic retinopathy (PDR) membranes. For the past decade, the medical education community has recognized lifelong learning as a desirable educational outcome. It is considered that tea stalk lignocellulose is an alternative low-cost adsorbent for preparing decaffeinated tea catechins. Aqueous solutions and oily suspensions of paracetamol and prednisolone zithromax antibiotic penicillin were tested in vitro that were also applied in the in vivo study. Deficient, suboptimal, or excessive S affects the growth and biosynthesis of secondary metabolites in adult plants.

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To investigate the cumulative prevalence of allergic diseases in Japanese university students and to identify explanatory variables including breastfeeding. In the case of an asymmetric field, the boundary profiles are shifted to the vasotec davis drug pdf field centre. Men with intermediate-risk PCa had the same risk of undergoing curative treatment as men with low-risk PCa, without compromising biochemical recurrence-free survival. Although both radial- and convex-arrayed endoscopic ultrasonography (EUS) scopes are widely used for observational EUS examinations, there have been few comparative studies on their power of visualization. Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry.

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To culturally translate and validate the Persian version of Kujala Patellofemoral Scale (KPS) and evaluate the test-retest reliability, internal consistency, construct validity and ceiling or floor effects of this instrument in patients with patellofemoral pain syndrome (PFPS). Energy and fiber intakes were consistently below recommendations, while total fat and saturated fat intakes were generally above recommendations and carbohydrate and polyunsaturated fat intakes were below to borderline low compared with recommendations. Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study. Phase- and polarization-sensitive near-field investigation reveals the characteristic antisymmetric polarization nature of the mode and explains the coupling mechanism. Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Twenty-nine premature infants (median gestational age 28 weeks, range 23-32 weeks) cared for in the neonatal intensive care unit of the King Edward and Princess Margaret Hospital in Perth, Australia, were treated with B breve at a dose of 1.66 billion organisms per day. We hereby define and describe a case of a lupus-like syndrome, which developed following the 4th infliximab infusion in a 62-year-old patient with ankylosing spondylitis (AS). The probe hybridized with the 13- and 8-kb fragments of PstI-digested total DNA in all isolates observed in the epidemic. The role of interleukin (IL)-4 as an important immunomodulatory cytokine is well established. Short communication: Quantifying bias in a single-trait international model ignoring covariances from multiple-trait national models.

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The promise of interprofessional education and outcome studies direct where the future is headed. High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and determining its subtypes. We use two methods 1) the computation of the eigenvalues of the linear operator defined by the linearized equations and 2) the formulation of the problem as a fixed point problem. This study examined the hypothesis that mAChR subtypes are heterogeneously distributed across brain stem nuclei that control breathing. A statewide cost-effectiveness study should be conducted to determine the economic viability of the program. In addition, the superficial layer was permeable to the injected methylene blue. At subsite -1, all of these hydrolases exhibit an aromatic amino acid that interacts with the hexopyranose ring of the monosaccharide undergoing catalysis. For the optimization the reliability analysis of the analytical system and the risk analysis of the measurement error are needed. Tetrabromobisphenol A diallyl ether (TBBPA DAE) was identified as the causative toxicant in sediment samples collected from a river near a brominated flame retardant (BFR) manufacturing plant in South China. Methane to Methanol: Structure-Activity Relationships for Cu-CHA.

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Correlates of plasma total homocysteine in patients with hyperlipidaemia. To assess geographical differences in diet, lifestyle and environmental contaminant exposure among pregnant women in Greenland, blood samples and questionnaire data were collected from 207 pregnant women in five Greenlandic regions (North, Disco Bay, West, South and East). Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. We show that sphingosine, a releasable backbone of sphingolipids, activates synaptobrevin in synaptic vesicles to form the SNARE complex implicated in membrane fusion. Satisfied blood flows in all arterial and venous anastomoses were obtained. We observed marked decrease of WBCs and neutrophils on blood examination.

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Regulation of laminin beta2 chain gene expression in human cancer cell lines. A technique is reported for repair of a bronchopleural fistula and obliteration of an empyema cavity using a combined breast parenchymal and expanded, musculocutaneous pectoralis major flap. The existence of regional endothermy in these groups is supported here by three different effexor weight gain reviews approaches including isotopic-based approximations, swimming speed inferences and the application of a novel methodology for assessing energetic budget and cost of swimming in extinct taxa. Patient age at initial examination ranged from 1 month to 9 years (mean, 2 y). The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells.

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