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Baclof

Baclof is not FDA-approved for back pain, but providers will often prescribe it for this as well as other types of pain. This is considered an "off-label" use of Baclof. It might work for you if your back pain is caused by muscle spasms. If your pain is dull and achey or feels like pins and needles, it might not help much.

Other names for this medication:
Bacfen, Baclof, Baclofen, Bacmax, Chinofen, Liofen, Parafon, Riclofen, Spinofen, Spinospas, Tefsole

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Also known as: Baclofen

Description

Intrathecal baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, cerebral palsy, or certain injuries to the spine. Intrathecal baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Intrathecal baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects.

This medicine is delivered by a drug pump directly into the spinal fluid of your back. A doctor will surgically place the pump and monitor the dose of the medication that is delivered by the pump. The dose of intrathecal baclofen will be different for different patients and will depend on the type of muscle tightness that you have.

Intrathecal baclofen is given only by or under the direct supervision of a doctor.

Dosage

This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Baclof. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation: For oral dosage form (solution): Adults and children 12 years of age and older—At first, 5 milliliters (mL) three times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day). Children younger than 12 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Baclof and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze.

Detailed Baclof dosage information

Side effects

The most common side effects associated with Baclof are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Quantitation of group-specific a antigen in hepatitis B vaccines by anti-HBs/a monoclonal antibody. Covalent linking of the conjugated polyelectrolyte moiety into the microgel prevents leakage of the fluorophore while keeping its fluorescence property. S-nitrosoglutathione and sodium nitroprus-side were used as NO donors and H. Comparative effects of University of Wisconsin and Euro-Collins solutions on pulmonary mitochondrial function after ischemia and reperfusion. A multi-institutional, retrospective cohort of 70 patients 45 years of age and under with head and neck squamous cell carcinoma (SCC) presenting over an 11-year period was studied. These adducts include HNE-His Michael adducts (MA), ONE-Lys 4-ketoamide, ONE-Lys pyrrolinone, and a Cys/His-ONE-Lys pyrrole cross-link. In this study, the stimulatory effects of B7RP-1 on cellular and humoral immune responses were investigated giving mice a construct with the extracellular domain of murine B7RP-1 fused with human IgG1 Fc (B7RP-1-Fc). Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder. In reported cases where aortic dissection has been missed, clinician awareness of the disease was not the primary issue but failure to respond to clinical cues suggestive of aortic dissection was.

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This finding, however, appears to be associated with the lack of on-site catheterization facilities at HMO hospitals. To determine the long-term outcomes of children exposed in utero to maternal parvovirus B19 infection. Graft-vs-host disease as a cause of enlargement of the epiglottis in an immunocompromised child. Such biological entities composed of various inorganic and/or organic compounds also contain trace elements. Using volumetric computational II reconstruction, we are able to recognize distorted and occluded objects with correlation based recognition algorithms. Implications for cognition, neuroscience, evolution, development, and artificial intelligence are explored. When selectively addressing a particular dot by quasiresonant phonon-assisted excitation, despite a rapid orientation relaxation on a 1-ps time scale, coherence is partly maintained. Many intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids.

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Solo practitioners, older GPs and female GPs are least likely to avail themselves of this resource. The effects of roasting temperature applied to whole soybeans on site of digestion by steers: II. Population genetics and adaptation to climate along elevation gradients in invasive Solidago canadensis. To investigate the effect of adrenomedullin (ADM) on seminal vesicle smooth muscle contractions in the rat and the specific receptor involved. This approach can be considered when there is heterogeneous perfusion of abdominal viscera by the true and false lumens of the chronically dissected aorta. At 30 days, the same staining intensity was observed in odontoblast-like cells and in pulp cells. The LV portion of the Vif SLV/Ix4Yx9Y motif was found to be required for optimal suppression of A3F, A3C, or A3DE. Meaning of context in recapturing self-care after stroke or spinal cord injury.

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In this overview and the associated reviews, the behavioral, genetic and neural factors that promote over-eating in animals and humans are discussed. The aim of this study was to analyze lymphocyte infiltration using immunohistochemistry in proliferative diabetic retinopathy (PDR) membranes. For the past decade, the medical education community has recognized lifelong learning as a desirable educational outcome. It is considered that tea stalk lignocellulose is an alternative low-cost adsorbent for preparing decaffeinated tea catechins. Aqueous solutions and oily suspensions of paracetamol and prednisolone zithromax antibiotic penicillin were tested in vitro that were also applied in the in vivo study. Deficient, suboptimal, or excessive S affects the growth and biosynthesis of secondary metabolites in adult plants.

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Correlates of plasma total homocysteine in patients with hyperlipidaemia. To assess geographical differences in diet, lifestyle and environmental contaminant exposure among pregnant women in Greenland, blood samples and questionnaire data were collected from 207 pregnant women in five Greenlandic regions (North, Disco Bay, West, South and East). Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. We show that sphingosine, a releasable backbone of sphingolipids, activates synaptobrevin in synaptic vesicles to form the SNARE complex implicated in membrane fusion. Satisfied blood flows in all arterial and venous anastomoses were obtained. We observed marked decrease of WBCs and neutrophils on blood examination.

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Regulation of laminin beta2 chain gene expression in human cancer cell lines. A technique is reported for repair of a bronchopleural fistula and obliteration of an empyema cavity using a combined breast parenchymal and expanded, musculocutaneous pectoralis major flap. The existence of regional endothermy in these groups is supported here by three different effexor weight gain reviews approaches including isotopic-based approximations, swimming speed inferences and the application of a novel methodology for assessing energetic budget and cost of swimming in extinct taxa. Patient age at initial examination ranged from 1 month to 9 years (mean, 2 y). The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells.

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Patients were treated with mastectomy and conventional adjuvant therapy. From global to regional: the importance of pneumococcal disease in Latin America. Infants 1 to 6 months of age with APN caused by bacteria other than E. Recombinant tissue plasminogen activator treatment in two infants with fulminant meningococcemia. Streptococcus pneumoniae strains lacking capsular polysaccharide have been increasingly reported in carriage and disease contexts. (3) This research provided more information about morphogenesis of rabies virus. CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion. NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL. GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity.

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We found highly specific activation of a pathway involving MYCN, LIN28B, Let-7 and HMGA2 in the C5 molecular subtype defined by MYCN amplification and over-expression, over-expression of MYCN targets including the Let-7 repressor LIN28B, loss of Let-7 expression and HMGA2 amplification and over-expression. Stochastic thermodynamics in mesoscopic chemical oscillation systems is discussed on the basis of chemical Langevin equation for the state variables with particular attention paid to a parameter region close nitrofurantoin monohyd macro 100 mg cap nort to the deterministic Hopf bifurcation. The implications of this linkage as well as the relationships between NCI, LI, tumor size and Kras-2 alleles are discussed. Thermoinactivation studies revealed that enzymatic activity diminished significantly at high temperatures, with greater loss of activity observed above 55 degrees C. Tissue factor pathway inhibitor (TFPI) inhibits tissue factor activity and may reduce thrombus formation in this setting. We find that pairwise strategies are effective with both small (cosmid) and large (megaYAC) targets and produce ordered sequence data with a high level of mapping completeness. Understanding the cause of artifacts and method of resolution is paramount in acquiring high-quality digital images.

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