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Aviglen (Glibenclamide)

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Aviglen is an oral diabetes medicine that helps control blood sugar levels. Aviglen is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Betrol, Codica, Combidos, Comdiab, Diabetnil, Diabetrol, Diabnil, Duotrol, Dutrol, Euglucon, Glibenclamide, Glime, Glimsug, Glinil, Glucomin, Gluconil, Glucored, Glucosafe, Glyboral, Glycurb, Glycurub, Glymep, Iscept, Metclam, Monomet, Pionorm, Secrin, Sugnil, Sugronil, Triglucored

Similar Products:
Lopid, Levothroid, Effexor, Zanaflex, Microzide, Exelon, Benzo, Tenaten, Revilife, Fenocap, Bisacodyl, Ecydin, Noritis,

Also known as: Glibenclamide


Aviglen is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Aviglen belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


Usual Adult Dose for Diabetes Type 2:

Standard Aviglen: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Aviglen: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Aviglen, micronized Aviglen, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Aviglen at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Aviglen dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Aviglen dosage information

Side effects

The most common side effects associated with Aviglen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Aviglen and metformin if you are allergic to Aviglen or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Aviglen and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Aviglen and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Aviglen and metformin.

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Rapid tolerance and crosstolerance to motor impairment effects of benzodiazepines, barbiturates, and ethanol. Every drug used in pregnancy carries a risk for teratogenicity and careful risk/benefit assessment should be done before prescribing them. Sedentary rats maintained on KD had increased adiposity and plasma leptin levels and decreased hypothalamic POMC mRNA, as compared to sedentary CH rats. Eighty-four undergraduate students, in dyads, were randomly assigned to one of two conditions (anti-alcohol message vs. Single-strain mobilomic sequence analysis uncovered plasmids and insertion sequence-associated circular intermediates in this environmentally important bacterium and enabled the description of evolutionary models for pesticide degradation in strain MH and related organisms. Serum vitamin D concentration is associated with falls, and vitamin D administration decreases falls. Unilateral congenital third cranial nerve palsy with central nervous system anomalies: report of two cases. A 43-year-old male patient was brought to our emergency room with a severe right chest wall-penetrating metal-rod injury, which had occurred after falling from a height. We present a case of a 63-year-old male who presented with right lower quadrant pain since 24 hours.

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Using data from the 2011-2015 March Current Population Survey Supplements, we compare the changes in insurance coverage and labor market outcomes over time of adults in states that expanded Medicaid and in states that did not. Systemic beta 2-mediated adverse effects also showed tolerance, which was mirrored by downregulation of lymphocyte beta 2 adrenoceptors. The total number for the three samples was 43 from the polar column compared to 39 from the non-polar column. Efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RV5) in healthy Chinese infants: A randomized, double-blind, placebo-controlled trial. The observed association between growth and amylase gene polymorphism is therefore more likely to be related to ingestion than to absorption cleocin dosage efficiency. SiO(-)/Si-OH groups from the mineral particles induce heterogeneous nucleation of apatite by sorption of calcium and phosphate ions. The system can be interpreted as a simple predator-prey metapopulation or as a spatially explicit predator-prey system. Inhalation rewarming from hypothermia: an evaluation in -20 degrees C simulated field conditions. Moreover, this formazan dye had a higher water solubility and more sensitivity. DNA fragmentation increased when cells were pre-stimulated with tumor necrosis factor alpha.

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In the case of massive and submassive PE, anterior and inferior T-wave inversion is the most frequent associated ECG finding. We evaluated the effect of octreotide on responses to noxious colorectal distension in rats. The cost function penalizes for the differences between the analytically derived average number of reaction products and their experimental counterparts. These results suggest that the rCBF values in the 1-compartment analysis were affected by radioactivity in the vessels. Surgery at a high-quality hospital (top quartile rates of radiation after breast-conserving surgery) or high volume (top quartile) hospital and receipt of definitive primary therapy (mastectomy or breast-conserving surgery with radiation).

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Immunohistochemical localization and differentiation of phosphocholine-containing antigens of the porcine, parasitic nematode, Ascaris suum. The immunosuppressive activity of Shigella sonnei differing by the presence of plasmid pSS120. Docking simulation was performed for compounds 7a and 7i into the BCR-ABL kinase structure active site to determine the probable binding model. Universal screening and intervention protocols to address multiple risk behaviors, including violent behaviors and substance use, may be useful to prevent injury among adolescents presenting to the urban ED. In this method, 3 microl of urine are blotted to one dot onto a cellulose acetate membrane, which is stained by a colloidal silver staining reagent, and the optical density of the silver stained urinary protein is measured at 500 nm using a densitometer. Perceived chewing ability increased with increasing number of teeth. TORC2 is a key regulator of lipid biosynthesis and Akt-mediated survival signaling. We synthesized the same radiotracer possessing several hundred to thousand times higher specific activity (high-SA IAZGP) via nucleophilic substitution and compared its biological behavior with that of conventionally produced IAZGP (low-SA IAZGP) to determine if specific activity is a factor influencing cell uptake kinetics, biodistribution and intratumor microregional localization of the radiotracer. A fluorescence assay to check the folding of potassium Kv channels expressed in vitro has been developed. The duration of the oestrous cycle was increased in lithium chloride-treated rat with longer metestrous and diestrous phases.

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The focus of this work is to introduce the typical clinical picture of Usher syndrome, summarize diagnostic options, and give an overview of therapeutic strategies. Human TERT expression was related to the Ki-67 labeling index, indicating that coupling of telomerase activation with cell proliferation was the associated mechanism for tumorigenesis. Although the introduction of azole antifungals for prophylaxis has had a significant impact on the incidence of candidal infections (especially those caused by C. Furthermore, relapse was induced by the injection of SEB at day 24. Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci. A retrospective analysis of all cases of hemipelvectomy was conducted in our institution over eight-year period with particular attention given to the reconstruction choices and associated complications. Low-fat dairy, but not whole-/high-fat dairy, consumption is related with higher serum adiponectin levels in apparently healthy adults.

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Ox-AT generated in the airway interacts directly with epithelial cells to release chemokines IL-8 and MCP-1, which in turn attracts macrophages and neutrophils into the airways. Side effects are more common after exposure to high-osmolar compared with low-osmolar ICM, suggesting that osmolality may be an important physical-chemical property related to nephrotoxicity. Optical reflectometry based on correlation detection and its application to the in-service monitoring of WDM passive optical network. At 3 h, the mucosal surface was completely ablated, by 6 h an epithelial covering was substantially restored and by 1 day there was full re-epithelialisation. All models produced similar predictions, but comparison of nested models indicated that the primary factors generating size-density scaling in mammalian carnivores are prey productivity, predator-prey size ratios, and consumer area of capture. This study was designed to investigate the use and impact of a continuous glucose monitoring system (the FreeStyle Navigator) under home-use conditions in the self-management of type 1 diabetes. Efficacy of an ultrasonic surgical system for laparoscopic adrenalectomy.

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IS ACUTE ANTERIOR POLIOMYELITIS SPREAD BY DIRECT PERSONAL CONTACT?: REPORT OF AN INTERSTING INCIDENT. After a median follow-up of 53 months, 732 pts had disease-related events (114 locoregional, 58 contralateral, and 560 distant metastasis). Both groups had significant improvements on the MSS and measures of strength. An aptamer switch probe (ASP) linking chlorin e6 (Ce6), a photosensitizer molecule, to the surface of gold nanorods (AuNRs) was used to target cancer cells for photodynamic therapy (PDT) and photothermal therapy (PTT). Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. The results showed that: (1) a few denervated Schwann cells survived and sustained their ability to myelinate axons at least 6 months, and (2) the atrophic denervated muscle could be reinnervated by regenerated axons through new muscle-nerve connections. Two weeks after plating, all the experimental groups expressed three germ layer markers and some primitive and definitive endoderm-specific genes. Effects of ORP150 on appearance and function of pancreatic beta cells following acute necrotizing pancreatitis. High-risk HPVs infect keratinocytes (KCs) and successfully suppress host immunity for up to two years despite the fact that KCs are well equipped to detect and initiate immune responses to invading pathogens. Dutch trial registry vasotec mg , under reference number: NTR3015.

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