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Atorvastatin

Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol. That may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Other names for this medication:
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Description

Atorvastatin (atorvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Atorvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors such as genetically high cholesterol.

Atorvastatin is for use in adults and children who are at least 10 years old.

Dosage

Take Atorvastatin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Atorvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day.

Do not break an Atorvastatin tablet before taking it, unless your doctor has told you to.

You may need to stop using this medicine for a short time if you have:

uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; or surgery or a medical emergency.

It may take up to 2 weeks before your cholesterol levels improve, and you may need frequent blood test. Even if you have no symptoms, tests can help your doctor determine if Atorvastatin is effective.

Atorvastatin is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Atorvastatin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Atorvastatin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Atorvastatin if you are allergic to atorvastatin, or if you have:

liver disease; or if you are pregnant or breastfeeding.

Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking Atorvastatin and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking Atorvastatin.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver problems; muscle pain or weakness; kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Atorvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Atorvastatin is not approved for use by anyone younger than 10 years old.

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Optimal intervention strategy for prevention tuberculosis using a smoking-tuberculosis model. Regardless of the primary trigger, vasculitides entail activation of the complement system as well as the contact/kinin system. Self-report of past depression was more strongly related to concurrent distress than to the earlier interview assessment of history of depression. (i) To evaluate the feasibility of detecting adverse lipid profiles in schoolchildren by measuring capillary dried blood spot apolipoprotein levels, and (ii) to assess the effect of age, sex and ethnicity on apolipoprotein levels. Transfer of flexor carpi ulnaris combined with selective release of the flexor pronator origin was undertaken in 35 patients with hemiplegic cerebral palsy for a pronation flexion deformity of the forearm, hand and wrist. However, signaling remained graded whenever Ste5 was allowed to function at the plasma membrane. Imaging H2(17)O distribution in a phantom and measurement of metabolically produced H2(17)O in live mice by proton NMR. Two hundred and eleven children with a primary anxiety disorder, whose mothers also had an anxiety disorder. The use of MMR status to assist AC recommendations for patients with stage II CC is an accepted practice for most Australian medical oncologists who responded to our survey. The mean TWIST was 27.05 months with CAP, 31.5 months with ChOP and 32.95 months with fludarabine.

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Platelet-derived growth factor receptor-alpha in ventricular zone cells and in developing neurons. Taxonomical and epidemiological aspects are examined in the light of recent results of biochemical analysis of parasites. The netlike pattern of K-structures corresponded well with ACM pattern. In particular, there exists the potential that they will make their way into water systems, e.g. The physical activity level in children with asthma based on a survey among 7-16 year old school children.

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Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Balancing reversion of cytotoxic T-lymphocyte and neutralizing antibody escape mutations within human immunodeficiency virus type 1 Env upon transmission. To that end, various strategies have been explored to increase blood vessel regeneration within defects to facilitate both tissue-engineered and natural repair processes. The small number of unsuccessful cases were related to inability of the catheter to traverse stenotic proximal obstructions within 2 cm of the RCA and LCA origins. The development of the low molecular weight heparin makes treatment at home a possibility.

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Cardiopulmonary functional reserve measured as peak oxygen uptake is predicted better at rest by measures of cardiac diastolic function than by systolic function. Sensitivity of Xanthoria parietina to UV-A: role of metabolic modulators. The intrathecal administration of ketamine also produced wind-up inhibition, the efficacy being higher in the monoarthritic rats. Analyzing a sample of 4,491 US men and 5,326 US women, we find that holding a supervisory position or being in charge of hiring and firing is positively associated with offspring count in men but not in women. Structural and sequence similarities among CA proteins of retroviruses and the CA-like proteins of hepatitis B virus and various retrotransposons suggest that the MHR is involved in an aspect of replication common to these reverse-transcribing elements. NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid. Current Protocols of Corneal Collagen Cross-Linking: Visual, Refractive, and Tomographic Outcomes. With the exception of the left renal artery, steady flow wall shear stresses were higher distal to ostia than proximal. Medical records of 57 patients with breast SSI and 268 randomly selected uninfected control patients were reviewed.

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Antidepressants (serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and nonsedating tricyclic antidepressants) are generally the most appropriate first-line pharmacotherapy for GAD, since they are also effective against comorbid psychiatric disorders and are suitable for long-term use. Using microelectrode recordings, a cortical tonotopic organization can be observed that was consistent with and expanded on the earlier cochleotopic data. Scrambled egg in the boxed lunches contained 20-40 ng/g of SEA, and 3.0 x 10(9)/g of viable S. Loss of adhesion is a fundamental step in the metastatic cascade. To analyze emerging trends in effective utilization of insulin in the treatment of type 2 diabetes. Recent peritonitis associates with mortality among patients treated with peritoneal dialysis.

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Individual models of biological networks (such as metabolism, transcription, and signaling) have played pivotal roles in driving microbial research through the years. In ex vivo coronary arteries, plaque burden by coronary CTA had extremely low inter-/intra-reader variability and correlated significantly with IVUS measurements. The Education Standards Task Force (expert panel) made final decisions in the four instances where this level of consensus was not reached, retaining all four items. Cholestatic hepatitis after liver transplantation is associated with persistently high serum hepatitis C virus RNA levels. Although octreotide leading to bradycardia and heart block has been documented in several case reports, to our knowledge, octreotide-associated asystole has not been described. Lack of knowledge of concussions could therefore be one of the main detriments to concussion prevention in hockey. Because the immune and inflammatory response to Leishmania (Viannia) species defines the outcome of infection and efficacy of treatment, immunomodulation is considered a promising therapeutic strategy. Choice of therapy depends upon the overall assessment of the patient with both conservative and more invasive definitive therapies available.

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Supervised hours requirements in graduated driver licensing: Effectiveness and parental awareness. Localization of EP(3) was examined by staining for beta-galactosidase knocked in at the EP(3) locus in EP(3)-deficient mice. In these cases the diagnosis is established on clinical examination, the results of USG and the aspiration biopsy. Relationship between anti-depressant use and lung cancer survival. These results indicate that the aberrant regulation of synaptic actin filaments and loss of synaptic NMDARs contribute to the manifestation of autism-like phenotypes. Small extracellular electric fields can guide the migration of amoeboid cells, and we established a large-scale screening approach to search for mutants with electrotaxis phenotypes from a collection of 563 Dictyostelium discoideum strains with morphological defects. Hospital mortality, causes of death and long term survival were analysed. The interaction of Iso with muscarinic receptors and endogenous nitric oxide was also investigated. Excessive sleepiness may be associated with respiratory failure, obesity, hypertension and insulin resistance in the cardiometabolic syndrome.

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Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution. Our goals were to describe and quantify redistribution of renal cortical blood flow during systemic hypotension in rabbits using contrast-enhanced power Doppler sonography and to explore the feasibility of creating real-time regional blood flow maps of the kidney. Therefore, the change of lipid amount in the cells, the subcellular localization and the downstream signal in a specific subcellular organelle should be clarified to understand the pathobiological significance of sphingolipids when extracellular stimulation induces a diverse of cell functions such as cell death, proliferation and migration. The mRNA levels of the known HPV16 E6 PDZ protein targets Dlg, Scribble, Magi-1, Magi-3, PSD95, and Mupp1 were not changed by HPV8 E6. The fidelity of treatment delivery can be assessed micardis plus medication in treatment outcome studies: a successful illustration from behavioral medicine.

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Prospective observational study of 102 outpatients with HNCs at a tertiary cancer centre in Melbourne between 1 May 2008 and 30 May 2009. Hierarchical logistic regression models were fitted to all deaths occurring in 2000 through 2004 by suicide. The mechanism underlying this discrepant effect of hypoglycaemia on psychomotor function remains unknown, but may be related to the difference in sympathoadrenal activation observed between the groups. burgdorferi with antibiotics used to treat the disease was distinctly biphasic, with a small subpopulation of surviving cells. Maternal Alcohol Use and Nutrition During Pregnancy: Diet and Anthropometry. A blood test was performed before and after biopsy, and a questionnaire survey was given after the biopsy. immunoglobulin A, plasma protein) in neonates differ from those in adults, which may complicate interpretation of measured drug concentrations. We examined five healthy volunteers and six patients over 6 weeks. Efficacy and safety of midodrine hydrochloride in patients with refractory vasovagal syncope. Evaluation of the self-administered bleeding assessment tool (Self-BAT) in haemophilia carriers and correlations with quality of life.

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Frozen-thawed ovarian cortical fragments (1 mm(3)) were autotransplanted to the uterus of completely ovariectomized goats. Enhancement of neutrophil infiltration in the corpus after failure of Helicobacter pylori eradication. However, absorption often is negligible and phase contrast has not been easily available. Since ectopic mineralization causes tissue dysfunction mineralization inhibitors and promoting factors have to be kept in close balance. Endoscopic ferromagnetic object retrieval by use of a simple magnet (with video). Multilevel analysis showed greater decreases in MPS between 6 and 9 years, and after 12 years of age, than between 9 and 12 years of age. Expanded CUG repeats fold into ds(CUG) hairpins that sequester nuclear proteins including human Muscleblind-like (MBNL) and hnRNP H alternative splicing factors. One-third of VTE events in cancer surgery patients occurred postdischarge.

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