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Aratan (Losartan)
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Aratan

Aratan and associated names, 12,5 mg, 25mg, 50 mg, 100 mg, film-coated tablets is an orally active angiotensin II (Ang- II) receptor antagonist. Aratan acts on the AT1 receptor subtype and blocks the effect of Ang-II in the renin angiotensin system (RAS) cascade. Aratan is indicated for the treatment of hypertension.

Other names for this medication:
Acetensa, Anreb, Cardon, Cardzaar, Cosart, Covance, Fensartan, Forzaar, Giovax, Hizaar, Lacine, Lifezar, Loben, Loortan, Loplac, Lorista, Lortaan, Losadel, Losamet, Losapot, Losar, Losardil, Losart, Losartas, Losartil, Losazid, Losium, Lospre, Lostankal, Lostat, Lotim, Lozap, Maxartan, Myotan, Niten, Portiron, Psycholanz, Sartens, Sedeten, Simperten, Sortiva, Tanlozid, Tarnasol, Tensiohess, Zartan

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Also known as: Losartan

Description

Aratan is a perfect remedy, which helps to fight against the symptoms of high blood pressure and to reduce the risk of stroke in people with hypertension. Its target is to treat kidney problems in people with type 2 diabetes. Aratan is also known as Losartan potassium, Cosart, Los-Po. Aratan acts by preventing the hormone angiotensin II from constricting the blood vessels, which tends to raise blood pressure. It is angiotensin II receptor antagonists. Generic name of Aratan is Losartan Potassium. Brand name of Aratan is Aratan.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Aratan dosage information

Overdose

If you overdose Aratan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Aratan overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Aratan if you are allergic to losartan.

Do not use Aratan if you are pregnant, and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

To make sure Aratan is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; an electrolyte imbalance (such as high levels of potassium in your blood); if you are on a low-salt diet; or if you are dehydrated.

You should not breast-feed while using Aratan.

Aratan is not approved for use by anyone younger than 6 years old.

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Both the Redistribution and the PathHunter assay could discriminate partial agonists from full agonists, whereas in the Tango assay partial agonists behaved as full agonists. Although measurements of B-type natriuretic peptide (BNP) levels are useful for the monitoring and prediction of outcomes in chronic mitral regurgitation, no data are available on the role of BNP measurements in the assessment of LAVV regurgitation in patients after surgical correction of PAVC. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. In patients with stroke or transient ischemic attack of undetermined origin, a noninvasive strategy of CIMT assessment/plaque screen and transthoracic echocardiography bubble study can identify patients in whom further invasive evaluation with TEE will be of low diagnostic yield. The features of bulbo-spinal serotoninergic reaction in the young rats under the condition of acute somatic paiN. If MR imaging confirms a dermoid or endometrial cyst, further diagnostic procedures may be unnecessary.

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Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. Cancer cells adhered only to the naked area of the submesothelial basement membrane, which was exposed by the shrinkage and exfoliation of mesothelial cells of the omentum. To determine if urinary symptoms are more common in women during the 4 weeks after a routine pelvic examination. SodCI binds to Salmonella and Bacillus peptidoglycan, but not peptidoglycan from Staphylococcus. Here, we map the receptive fields of macaque area V4 neurons during saccadic eye movements and find that receptive fields are remarkably dynamic.

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Understanding direct salt effects on protein crystal polymorphism is addressed by comparing different crystal forms (triclinic, monoclinic, tetragonal and orthorhombic) for hen, turkey, bob white quail and human lysozymes. Reynolds number effects on wavelet components of self-preserving turbulent structures. The present study investigated (a) whether autonomic function would differ in SAR patients and healthy controls, and (b) whether acupuncture treatment would evoke changes in autonomic function compared to sham acupuncture. Cell-to-cell communication mediated by Cx40 may be implicated in the function of renin-secreting cells, hence participating in the control of blood pressure. CC chemokine receptor 2 is expressed on Ly6C(hi) monocytes and plays an essential role in their extravasation and transmigration into the brain after cerebral ischemia. bcl-2 antisense oligodeoxynucleotides (ODNs), bcl-2 sense ODNs, or artificial cerebrospinal fluid (CSF, vehicle) was infused into the lateral ventricle for the 72 hours between the 20-minute ischemic preconditioning and the 60-minute period of ischemia. It is followed by a strip of negative spin density that extends until the crossing of the local Fermi energy with the degeneracy point where the two spin subbands intersect.

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Pay as You Speed, ISA with incentives for not speeding: a case of test driver recruitment. Finally, we evidenced HSA binding to calcium oxalate monohydrate (COM) crystals in a solution similar to urine.(ABSTRACT TRUNCATED AT 250 WORDS). Mitochondrial respiratory chain disorders are the most common disorders among inherited metabolic disorders. In this review, we discuss the role of the endocannabinoid system in gastrointestinal physiology. CONCLUSIONS: The mechanical characteristics and resulting injuries of porcine spinal motion segments were affected as the loading rates changed from quasi-static to dynamic. After the last excitation allergic rhinitis was diagnosed according to the accumulation score about nasal symptom.

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The cystic brain tumor contained proinsulin and insulin at concentrations of 13.6 and 1.22 nmol/L, respectively. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. Identification, characterization, and functional studies of a Pelle gene in the Chinese mitten crab, Eriocheir sinensis. Myocardial efficiency and sympathetic reinnervation after orthotopic heart transplantation: a noninvasive study with positron emission tomography. The phytoplankton functional groups were classified based on the C-R-S growth strategy and its favored habitat. The hydroxyl radical scavenging effect of textile preparation auxiliaries on the photochemical treatment of nonylphenol ethoxylate.

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The value of HMPAO SPECT in predicting treatment response to citalopram in patients with major depression. After acutely treating female rats with lower (7.5 mg/kg) or higher (15 mg/kg) doses of olanzapine, we assessed glucose intolerance using the glucose tolerance test and measured insulin resistance using the homeostatic model assessment of insulin resistance equation. The fourth passage ADSCs were induced to differentiate into adipocytes with adipogenic inducing fluid and determined by Oil Red O staining, into osteoblasts with osteogenic inducing fluid and determined by Von Kossa staining, as well as into smooth-muscle-like cells with inducing fluid containing beta-mercaptoethanol, and the expression of alpha-smooth muscle actin (alpha-SMA) was detected by the immunohistochemical method. Interleukin-1 beta stimulates mitogen-activated protein kinase in U373 astrocytoma cells without the production of lipid second messengers. The smallest quantum code that can correct all one-qubit errors is based on five qubits. ATP-gated P2X(7) purinoceptors are found in most immune cells of the periphery and the brain where their activation leads to multiple downstream events such as cell permeabilization, apoptosis, and/or cytokine release. The antigen recognized by GB3 has been identified as laminin-5, a glycoprotein consisting of three subunits (alpha 3, beta 3 and gamma 2). In addition to a PX (Phox homology) domain that regulates its endosomal localization, SNX27 has a unique PDZ (Psd-95/Dlg/ZO1) domain and an atypical FERM (4.1, ezrin, radixin, moesin) domain that both function to bind short peptide sequence motifs in the cytoplasmic domains of the cargo receptors. Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion. Certain tasks tap weaker representations, while other tasks require stronger representations, leading to dissociations in behavior.

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