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Alrest (Clonazepam)

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Alrest is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Alrest works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Almac, Alrest, Azpax, Catier, Cleps, Clodep, Clonapik, Clonoasig, Clonopam, Clonotril, Clotweet, Clozep, Clozipam, Convaclon, Cozil, Deptune, Dipwell, Eminaz, Epicloz, Escitrac, Estalonix, Jasoclam, Jbcloz, Lonazep, Lozep, Meloprax, Onapil, Petril, Prasilife, Rivotril, Zeficar, Zepam, Zeptril, Zozep

Similar Products:
Daklinza, Prilosec, Suprax, Propecia, Coreg, Tramot, Metral, Exermet, Farlutal, Cloplat, Ovitec, Alipid, Hydrodiuril,

Also known as: Clonazepam


Alrest (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Alrest is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Alrest is also used to treat panic disorder (including agoraphobia) in adults.


This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Alrest Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.


Benzodiazepines like Alrest became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Alrest together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Alrest Wafer dosage information

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


For children, the long-term effects on physical and mental/behavioral development are uncertain and may not be seen until after many years. Therefore, discuss the risks and benefits of treatment with Alrest with your doctor.

Older adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

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Assays of glucose entry, glucose transporter amount, and translocation. (99m)Tc-HMPAO WBC scintigraphy may be a useful tool to evaluate response to therapy in patients with active bronchiectasis. Expression and Purification of HCV Core and Core-E1E2 Proteins in Different Bacterial Strains. Inclusion criteria were: written in English, study population of CSE patients, follow-up time of at least 1 year. This study showed that Rutin has neuroprotective effect and reduces cisplatin- neurotoxicity with possible mechanism via the antioxidant pathway. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. Ovarian hyperstimulation syndrome is also becoming common because of treatment of infertility with assisted reproduction techniques. FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Effects of fludrocortisone on water and sodium intake of C57BL/6 mice. Tissues were examined by radioimmunoassay, immunoblotting, or immunohistochemistry for ITF, SP, and transforming growth factor alpha (rat) or ITF and pS2 (human) expression.

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Impact of point-of-care management on the transmission of anogenital gonococcal infections among men who have sex with men in Amsterdam: a mathematical modelling and cost-effectiveness study. These findings suggest that the data from all 6 laboratory locations are consistent with each other and are congruous with those found in other N400 studies and will permit pooling of subject data for future research. Identification of N-terminal autodigestion target site in subtilisin ALP I. To evaluate the psychometric properties of two adapted versions of the interpersonal communication competence scale (ICCS) that were applied to people with acquired brain injury (ABI). Over 500 proteins were identified in the midguts of flies from both feeding groups, 13 of which were shown to be differentially expressed in trypanosome-stimulated vs. MTX-NLC nanogel was prepared by hot-homogenization method and optimized by Design of Experiments. NBUVB, mycophenolate, and methotrexate remain the reasonable first-line systemic treatment options for atopic dermatitis.

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Blood transfusion is considered safe when the infused blood is tested using state of the art viral assays developed over the past several decades. We report here seven male patients with a benign motor neuron syndrome highly analogous to Kennedy disease but with a normal trinucleotide repeat. Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels. Resources should be redirected to mitigate renal injury in high-risk patients. We performed a comparative genomics analysis in order to find genetic determinants responsible for the differences observed. The glycolipopeptide elicited potent humoral and cellular immune responses. The apparent endemism of abelisauroids to southern Gondwana during Pangean times might be due to the presence of a large, central Gondwanan desert. Due to direct impacts on offspring survival and development, however, mosquito choice in oviposition site can have important consequences for population regulation that should be taken into account when designing vector control programs.

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We investigated whether the survival of patients with Dukes C colon cancer treated with adjuvant chemotherapy is influenced by K-ras and TP53 mutations. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21. To investigate the pharmacologic activity of the two enantiomers of cetirizine, we conducted a randomized, double-blind, four-way, crossover study to assess the effect of treatment with 5 mg levocetirizine, 5 mg dextrocetirizine, and 10 mg cetirizine and matched placebo, on histamine-induced changes in the nasal airways of 24 healthy volunteers. Moreover, we found that intestinal P-glycocoprotein has a prominent role in the extrusion of several drugs from the blood into the intestinal lumen, and in preventing drugs in the intestinal lumen from (re-)entering the bloodstream. These data support the hypothesis that PGs produced by Kupffer cells in response to glucagon might participate in a feedback loop inhibiting glucagon-stimulated glycogenolysis in hepatocytes.

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Inuits and the general population in the tropics have similar concentrations. RA enhances endogenous p53 transactivation activity in NT2/D1 but not NT2/D1-R1 cells. OPCML, located at 11q25, is one of the downregulated genes we identified through digital expression subtraction. Strong CD137 expression was found in blood vessel walls, on the endothelial layer, and on the vascular smooth muscle cells. We used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation of therapy and after 6 or/and 12 months of treatment. Findings from subjects with normal and high susceptibility to periodontal disease.

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In conclusion, microbiological bone samples are not suitable as an indicator for the time point of secondary wound closure. Cancer Awareness Resources to go (C.A.R.T.): a project to increase access to cancer patient education at the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. NF-kappaB activity was evaluated by electrophoretic mobility shift assay. Most of the ABC genes and all three SEPALLATA genes encode MADS transcription factors, which bind to DNA as dimers. After the addition of a test sample, we used biotinylated isolectin B4 from Vicia villosa and avidin-peroxydase to act as a detection system. We also briefly review structure-based antigen or immunogen design, with application to rational vaccine development.

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These sub-beams experience a relative time delay, which translates into a phase difference, thus forming a phased array. A key mechanical feature of orb-web design is the high elasticity of the capture spiral. Hirsutism score, serum basal gonadotropin, androgens, estrogen, and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and every 3 months during treatment. Stem Cell Differentiation Stage Factors and Their Role in Triggering Symmetry Breaking Processes during Cancer Development: A Quantum Field Theory Model for Reprogramming Cancer Cells to Healthy Phenotypes. Records of 59 patients with corneal how long does diflucan 150 mg take to work ectasia seen in consultation over 6 months were reviewed. The scent of senescence: age-dependent changes in the composition of the cephalic gland secretion of the male European beewolf, Philanthus triangulum. Pilot Study on the Effect of Ramelteon on Sleep Disturbance After Traumatic Brain Injury: Preliminary Evidence From a Clinical Trial.

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Videofluoroscopic evaluation of adenoid hypertrophy and velopharyngeal closure during speech. Socio-economic deprivation is associated with higher rates of HIV-TB and non-HIV-TB. She was treated with combination chemotherapy and complete remission was achieved. X-ray endoscopic diagnosis and treatment of iatrogenic injuries of the upper urinary tract. Of the steroids examined, hydrocortisone most effectively inhibited the secretion of tenascin-C. In contrast, females exhibited a particularly strong preference for walking-hen stimuli, but only when they had rulide tablets 300mg been trained with it. The trans-2-aryl-3-nitro-tetrahydroquinoline products are obtained in high yields and in good enantioselectivities with a bifunctional tertiary amine-thiourea catalyst. Antibody blocking experiments suggest that a transient interaction between HLA-DM and the MHC class II-CLIP complex is required.

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A multiple logistic regression analysis was performed to estimate the extent to which body-related variables affect female smoking. Both density and proportion of GABA cells were higher in the occipital cortex than the prefrontal cortex between embryonic day 110 and 140, indicating late development of the prefrontal area. Clorgyline (1.0 mg/kg/day) administered via osmotic minipumps blocked the development of locomotor sensitization to the dopamine receptor agonist quinpirole (0.5 mg/kg every 3 days for 8 injections). We evaluated the association between lifelong residential exposure to green space and attention during preschool and early primary school years. NA-5HT increases the steady-state inactivation of Ca(V) 3 channels, reducing the number of channels available to open during depolarization. We present a noteworthy example of the inadequacy of MRI in revealing SCIWORA, a term that is antiquated as we combine the latest imaging techniques with a better understanding of the biomechanics of trauma and spine injury. An SIR epidemiological community-structured model is constructed to investigate the effects of clustered distributions of unvaccinated individuals and the distribution of the primary case relative to vaccination levels.

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Additionally, miR-106b inhibition decreased tartrate-resistant acid phosphatase-positive cell numbers and suppressed murine bone marrow macrophage differentiation. Serum Cr and CysC levels were measured once within 1 month prior the commencement of chemotherapy. Neonates with other congenital deformities, arthrogryposis and myelomeningocele were excluded. Combined surgical therapy of peri-implantitis evaluating two methods of surface debridement and decontamination. Knowledge about family caregiving is valuable for nurses as there is an emphasis on collaboration between family caregivers and professionals. The present study revealed that UTIs in both catheterized and non-catheterized patients was shown very high resistance pattern to amethopterin most of antibiotics in use mainly at Jimma University Teaching Hospital, southwest Ethiopia.

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Resorptive areas and an irregular root surface of the intruded teeth were noticed, according to the same pattern described above. Signal detection responses (correct detections and false alarms) and CBFV declined significantly over time in a linear manner for both modalities. An attempt was made to fit the serum concentrations of PSA-F, PSA-ACT, and PSA-T for each patient to exponential curves by applying one- and two-compartment models for pharmacokinetic analysis. Adhesion re-formation after relaparotomy was found to decrease significantly through the use of PVA-gel. Although these neurons lost their muscle targets and experienced the endocrine cue that normally triggers death, they showed no overt electrophysiological or morphological signs of degeneration. Sympathetic hyperinnervation of the uterus in the estrogen receptor alpha knock-out mouse. After 3 hours the surviving animals were killed, and SAH was confirmed by postmortem examination.

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Therefore, emerging zero-fluoroscopy catheter-guidance techniques are of great interest. Multicenter trials in Southeast Asia have shown better survival rates among patients with severe malaria, particularly those with high parasitemia levels, treated with intravenous (IV) artesunate than among those treated with quinine. Retrieval of inhibitory avoidance has been recently shown to require intact glutamate receptors, protein kinases A and C and mitogen-activated protein kinase in the CA1 region of the rat hippocampus and in the entorhinal, posterior parietal and anterior cingulate cortex. The remaining patient, a 94-year-old man, was unable to ingest food because of dysmasesis. Hemorrhagic shock results in secretion of proinflammatory cytokines into the intestinal lumen.

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However, these same innate immune responses may inadvertently lead to excessive inflammation or apoptosis at the maternal-fetal interface. In vivo acute toxicological studies of an antioxidant extract from Mangifera zebeta generic indica L. In this study we show that a cysteine residue introduced into the gating loop by replacement of Asp-336 displayed a rather high reactivity and was used to monitor structural changes in FhuA upon binding of ferrichrome. Physician reports of treatment plans, presumed causes of observed vital sign abnormalities, and degree of certainty were compared before and after knowledge of point-of-care ultrasonographic findings. In this paper those studies are extended to initially model the concomitant resistance case. Individuals with chronic neck pain with mild disability did not differ from a control group in terms of peak plantar pressure or center of pressure oscillation. Ophthalmologic evaluation and fluorescein angiography gave findings consistent with OIS, while vascular ultrasound evaluation and aortic arch angiography verified right CCA occlusion accompanied by an extensive collateral network.

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Investigations in three-dimensional culture unveiled a modulatory role of c-src during in vitro angiogenesis. The Gim proteins have one function related to alpha-tubulin and another to Tub4p, supported by the finding that the benomyl super-sensitivity is caused by a reduced level of alpha-tubulin while the synthetic lethality with tub4-1 is not. This review presents the development of biomarker monitoring in sports doping control and focuses on the implementation of the Athlete Biological Passport as the current concept of the World Anti Doping Agency for the detection of blood doping (hematological module). As recurrence is common, patients should be fully investigated and followed up long term. Beyond their chemotactic effect on mononuclear leukocytes, chemokines may also interfere with smooth muscle cell migration and growth, as well as platelet activation and other well-defined features of the atherosclerotic process. Antioxidant Therapy: Is it your Gateway to Improved Cardiovascular Health?. Nucleotide sequence of the mitochondrial DNA control region was determined for the formalin-preserved specimen of the individual European vendace, Coregonus albula, belonging to an extinct population. The concentration of these compounds has been evaluated in healthy and Botrytis cinerea infected grape clusters, both in natural vineyard conditions and in response to UV elicitation.

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Improving position-specific predictions of protein functional sites using phylogenetic motifs. However, detailed genetic involvement has not been ascertained in the great majority of cases. As a result, bone mass increases more after exercise when it has been exposed to sex hormones. This study describes the HRQOL and its determinants among black patients diagnosed and treated for Hypertension in Nigeria. Both cell lines were responsive to all genotoxicants, producing concentration-dependent can you take flagyl pill while on your period results with respect to genotoxicity. Therefore, we screened autoimmune sera by immunofluorescence of human fibroblasts and identified one serum that immunostained a distinct nuclear structure with a size and nuclear localization consistent with the Barr body. The MCI patients who lived alone had poorer social relationship QOL. We used modified ANNs to identify a repeated analysed sample out of that data pool. Fine needle aspiration performed on the upper, middle, and lower poles of each testis.

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