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Alpra (Alprazolam)

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Alpra is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpra, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpra is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Albiz, Alflux, Allam, Alpram, Alpranex, Alzokam, Alzolam, Alzot, Anzilum, Benzolam, Dizeral, Emlol, Enxolam, Fluxozam, Indolam, Luzarn, Mebaspa, Oclam, Onapract, Parazolam, Plxna, Pyrex, Xerodep, Zeecam, Zolyde

Similar Products:
Paxil, Geodon, Precose, Klonopin, Neoral, Terramycin, Taremis, Finzole, Metronidazole, Leukeran, Dianorm,

Also known as: Alprazolam


Alpra is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alpra is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alpra if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alpra or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alpra. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Alpra dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpra XR dosage information

Side effects

The most common side effects associated with Alpra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. Safety and efficacy have not been established.

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Nationwide Assessment of Robotic Lobectomy for Non-Small Cell Lung Cancer. Isolated LV diastolic dysfunction was independently associated with lower peak exercise LV systolic performance in patients without CHF. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity. Although they are histologically benign, these tumors often invade through the cranial base into the infratemporal and pterygopalatine fossae. Using modified Fried frailty phenotype measures, frailty criteria included gait speed, hand-grip strength as measured by a dynamometer, and self-reported exhaustion, low physical activity, and unintended weight loss. Exhaustive extraction and fractionation of wheat flour proteins. PID is highly specific, detecting only those movements which involve a change in location. Heterotrophic plate counts, Pseudomonas aeruginosa, Legionella spp. The problem with interpreters: communicating with Spanish-speaking patients.

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The analgesia resulting from activation of this system is possibly overshadowed by substances that concomitantly stimulate nociceptor hyperalgesic mechanisms. Patients with chronic LBP had more fear-avoidance beliefs for work than patients with acute LBP. The influence of giardiasis on the course of viral hepatitis in children. The broader significance is that this method can be applied to other structural pathology analysis in clinical practice. This study aimed to assess whether CAD incidence varied with season between UK and Australian sites. Diverse classes of non-coding RNAs, including snRNAs (small nuclear RNAs), play fundamental regulatory roles in gene expression. Furthermore, one of the discovered ergothioneine biosynthetic enzymes provides the first example of a rhodanese-like enzyme that transfers sulfur to non-activated carbon. CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. Although the disrupted neural representations and performance of movement have been observed in older age in previous studies, the relationship between the functional integration of sensory-motor (SM) system and aging could be further investigated.

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High shear rates induce decreased fibrin deposition and appearance of fibrin monomers. Online monitoring of trace chlorinated benzenes in flue gas of municipal solid waste incinerator by windowless VUV lamp single photon ionization TOFMS coupled with automatic enrichment system. These coherently aligned catechol-terminated molecules on the atomically smooth gold surface led to significanty more reproducible and thus more physico-chemically meaningful measurements than was possible before by employing rough gold surfaces. We describe six patients with cutaneous manifestations of lupus erythematosus who were treated with isotretinoin, 1 mg/kg/day. The prognostic value of tomographic myocardial perfusion imaging with dipyridamole or adenosine in patients with left bundle-branch block has not been established. To establish whether the concurrent ragweed and mugwort pollen hypersensitivity is the result of co-sensitization or of co-recognition by using purified recombinant allergens. Beyond food: The multiple pathways for inclusion of materials into ancient dental calculus. All types of tumor cells expressed alkaline phosphatase activity to a significant degree. Instrument development, descriptive statistics, and cross-informant variance. By Alkyl Nitriles, Alkyl Acetylenes and Insect Juvenile Hormones.

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At high concentrations of soluble tissue factor no effects of factor XI are seen on coagulation and fibrinolysis. The body flea index of Chinese gerbil foci reveals significant spatial and temporal aggregation characteristics through the employing of spatial autocorrelation. In this study, we found strong immunosuppressive ability of ASC sup in an allergic airway mouse model. Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart. We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period. The alterations of the cell phenotypes in bone marrow, thymus and spleen were determined by immunofluorescent staining using anti-mouse CD3, CD4, CD8a, CD19, IgM or CD45R/220 mAb through FACS analysis. The advent of CT scans has allowed nondestructive sampling of anatomy that cannot otherwise be studied in these extinct lions, leading to a more accurate reconstruction of endocranial morphology and its evolution. There is feedback accommodation mechanism between ROS increasing and MMP elevation in endothelial cells. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. We immediately applied argon plasma coagulation since surgical resection was also considered a high-risk procedure because of the submucosal pus and multiple comorbidities.

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The spread of advantageous transgenic genes from crop plants into wild and weedy relatives is a potential ecological problem. Lactoferrin (LF) is an iron-binding glycoprotein with antioxidant, anti-inflammatory and nitric oxide-dependent vasodilatory properties. Baboon fibronectin has subunit sizes, CNBr and thermolysin peptide patterns and an amino acid composition similar to human fibronectin. These investigations are beneficial to optimizing frequency noise property to promote the wide application of the DBR-SFFLs. In addition, it finalizes policies for the Skilled Nursing Facility Value-Based Purchasing Program that will affect Medicare payment to SNFs beginning in FY 2019. Our objective was to understand how patient experience differs between a PCMH demonstration practice designed for homeless people in Massachusetts and other practices participating in the same statewide initiative.

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A new murine model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone. The aim of this study was to investigate the possible pathogenic nature of a novel SRY mutation (p.Y127H) identified in a 46,XY female patient. This association shows which disorders must be considered, the differential diagnosis and methods of therapy. Incidence of diabetic peripheral neuropathic pain in primary care - a retrospective cohort study using the United Kingdom General Practice Research Database. Chronic thumb-sucking: the psychologic effects and the relative effectiveness of various methods of treatment. Based on the results of the species validation method, we propose that at least two species of Prasiola associate with the lichen-forming fungus Mastodia tessellata. Additionally, these findings suggest the existence of basal phosphorylation that is a dynamic process that involves both phosphorylation and dephosphorylation. Functional MR imaging has promise for more precise anatomic and functional imaging studies of brain interaction than have other imaging modalities.

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The nucleotide sequence of the cDNA clones and the deduced primary amino acid sequence of the carboxy terminal portion of the human L1 are homologous to the corresponding sequences of mouse L1 and rat NILE glycoprotein, with an especially high sequences identity in the cytoplasmic regions of the proteins. The interstitial nucleus of Cajal (iC) also has direct premotor control of vertical extraocular motoneurons and is probably involved in the maintenance of vertical eye position. Using chemical standards and metabolites extracted from serum samples, we optimized the LC-DIA-MS parameters to analyze hydrophilic metabolites and lipids. Clinical experience with Myambutol in the treatment of polyresistant chronic tuberculosis. Each region was assessed on each side separately on bone window scans. Additionally, TBI and PTSD often demonstrate overlapping symptoms. Whether pancreatic and liver steatosis impairs insulin secretion is controversial. Effect of dry matter levels of alfalfa silage on intake and metabolism in the ruminant.

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Involvement of neurotransmitter and neuropeptides in behavioural action of some neurohormones. The two structures revealed that the sequence of TDG that resembles the SUMO-binding motif (SBM) can form an intermolecular beta-sheet with either SUMO-1 or SUMO-3. Speech-language pathologists have the skills and knowledge needed to play an important role in the early identification of children who are at risk for reading difficulties. Seventeen children aged 7-10 years diagnosed with ADHD and 16 healthy children underwent a magnetic resonance scan for cortical thickness measurements. Computationally simpler methods are prone to a variety of aberrations and poor coverage properties. A typology is proposed that characterizes information needs as consciously recognized, unrecognized, and currently satisfied. Through label-free quantification of phosphopeptides, we identified a number of proteins that significantly changed phosphorylation state in response to short-term vasopressin treatment: AQP2, Bclaf1, LRRC47, Rgl3, and SAFB2.

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Murine models of experimentally-induced endotoxaemia and Toll-like receptor-4 deficiency suggest that endotoxin may promote the metabolic disturbances that underpin these diseases. However, many of the adjuvants currently in use can cause adverse events, raising concerns regarding their clinical use, and are geared toward productive immune responses but not necessarily tolerogenic responses. The issue of the burnout of carers of disabled family members has been raising concern for several years. Extracts of 40 different plant species used in the traditional medicine of the Australian Aboriginal people have been investigated for antiviral activity. The stigma of mental health in athletes: are mental toughness and mental health seen as contradictory in elite sport?. Doppler echocardiography showed that there was no significant left ventricular outflow obstruction.

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Isolated reports have documented supply from branch vessels of the abdominal aorta, including the celiac axis and inferior phrenic artery. Successful treatment of a fracture of a huge Achilles tendon ossification with autologous hamstring tendon graft and gastrocnemius fascia flap: a case report. DNA was extracted from paraffin-embedded sural nerve biopsy samples and screened for connexin32 mutations to verify the possible diagnosis of CMTX. While the rectangular form is shown to retain the metallic and superconducting (SC) properties of the bulk, spectacularly contrasting properties emerge in the honeycomb form of NbN: it exhibits (a) semiconducting electronic structure suitable for valleytronics and photocatalysis of water splitting, (b) piezoelectricity with a spontaneous polarization originating from a rare sd(2)-sp(2) type hybridization, and (c) a wide gap in its phonon spectrum making it suitable for use in hot carrier solar cells. Patient engagement has become a major focus of health care improvement efforts nationally. Volumetric Analysis of Carotid Plaque Components and Cerebral Microbleeds: A Correlative Study. In addition, the incidence of relapses of the nodular lesion was reduced with this purified preparation. The patient was a 60-year-old Chinese male with numbness, orthostatic hypotension, and gastrointestinal symptoms. Human dignity and autonomy in the care for patients with dementia: differences among formal caretakers from various cultural backgrounds.

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In our previous work, we fabricated a three-dimensional porous scaffold based on mineralized recombinant human-like collagen, nano-hydroxyapatite/recombinant human-like collagen/poly(lactic acid) (nHA/RHLC/PLA). Detection of Neisseria meningitidis using surface plasmon resonance based DNA biosensor. Occupational exposure generated a distinct plasma metabolome with markedly altered lipid and amino acid metabolites. Populations selected in complex environments evolved into genetically diverse communities. The objective of this study was to study efficacy of PRP therapy in follicular unit extraction (FUE) hair transplant. Survivors and non-survivors were compared regarding injury site, injury type and number of transfusions given. Purification and characterization of a novel caffeine oxidase from Alcaligenes species.

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Inhibitory effect of sucrose ester of lauric acid on the growth of Escherichia coli. Adequately powered, preferably cluster RCTs are needed to confirm these findings. Subsite distribution and incidence of colorectal cancer in New Zealand, 1974-1983. Two-dimensional gel-electrophoretic comparisons of af and wild-type embryos demonstrated that two proteins, having estimated molecular masses of about 38 kDa (pI 6.6) and 78 kDa (pI 7.6), were missing in af embryos. The patient, 49 years old, was admitted to Addiction Treatment Unit, Department of Psychiatry in Bydgoszcz.

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Activity of quinoxidine in experimental mennigitis of rabbits caused by Bacillus pyocyaneous. This study provides, for the first time, insight into genomic networks of obesity and their modulation by electro-acupuncture, which in turn reveals potential mechanisms that explain acupuncture-induced weight-loss. Radioisotope-labeling of organic compounds with C-12(gamma,n)C-11-reaction using breaking radiation by a 35-MeV-betatron. The purpose of this study was to obtain preliminary data regarding the effects of cardiomyoplasty on health-related physical function and quality of well-being. They contained an electron-dense core of storage proteins surrounded by an electron-translucent layer, and some vesicles also contained small vesicle-like structures. DNA microarray technology was used to analyse global transcriptional profile in human lymphoblastoid AHH-1 cells at 4 h after exposure to 0.5 Gy of gamma-ray. For this, we first propose a method of producing the Gibbs sampler using bio-inspired digital noisy integrate-and-fire neurons.

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Most importantly, ZnO-NP-induced ROS may promote global hypomethylation in cells by triggering the expression of TET-enzymes, avoiding DNMT interferences. Plasma proteins as nutritional indicators in the perioperative period. Steroid therapy is a critical component of the treatment algorithm, being administered at high doses and for prolonged periods to switch off immune over-activation. A key message is to promote oral health as part of overall health. Weight gain and edema were more common when muraglitazar was compared with a submaximal dose of pioglitazone. Survival Predictions of Ceramic Crowns Using Statistical Fracture Mechanics. These outermost leaves contained only chlorophyll forms like the mature green leaves. This study aimed to determine the mechanisms of resilience in children exposed to depressive symptoms postnatally. Here, we investigate the expression and role of one such group of modulators, the myomodulins, in the feeding system of Lymnaea stagnalis.

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However, it has not been described after uncomplicated elective extremity surgery. Finally, a numerical simulation example is presented to demonstrate the effectiveness of our proposed approach. Questions of surgical treatment are dealt with shortly when analyzing reoperations in cases of thoracic outlet syndrome. Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer. The outcomes of this what cold medicine can i take with bystolic pilot study will indicate whether DECADE is a promising intervention in the domain of patient-centered prevention of cardiovascular diseases (CVD) and whether a larger multi-center randomized controlled trial is feasible.

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This article describes results of a quality improvement project review of 5 years of capacity evaluations for independent living conducted in one Home-Based Primary Care (HBPC) Program. In order to develop effective interventions for restoring upper extremity function after cervical spinal cord injury, tools are needed to accurately measure hand function throughout the rehabilitation process. The epithelial tumour cells stained positive for cytokeratin (1-8, 10, 14-16, 18 and 19), oestrogen receptor, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA) and gross cystic disease fluid protein 15 (GCDFP-15). Electrostimulation in fecal incontinence: relevance of the sphincteric compound muscle action potential. It is concluded that the high GSH content of SKOV-3 cells provides a significant protection against 4-OH-CP by limiting the breakdown/activation of 4-OH-CP. Analyzing the international literature of the last 25 years, most papers focused on the minimally invasive treatment of pediatric varicocele. All available data support a function of IdiA as an Mn-binding protein that facilitates transport of Mn via the thylakoid membrane into the lumen to provide photosystem II with Mn. In the adult rat, expression levels of p35 mRNA are generally higher in the brain than in the spinal cord, while the converse is observed for p39 mRNA.

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The results indicated that the SYBR Green real-time RT-PCR could detect ISAV of different geographic origins or laboratory sources. Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. The in vivo effect of isocyanate-induced asthma on basophil histamine release. Differentiation of papilloedema from pseudo-papilloedema by fluorescein ophthalmoscopy. Radiologic measurements of adiposity were obtained from preoperative CT scans. Following a standard development process, we could yield a design that meets clinical needs. In addition, this study describes changes in CD77 and CD34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. Cannabinoids and their derivatives have been utilized for their medicinal and therapeutic properties throughout history.

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When the heme biosynthetic pathway was blocked by succinylacetone there was a large increase in both 5-aminolevulinate synthase activity and protein levels, and this was reversed by the addition of exogenous hemin. ORT is found in DME treated with anti-VEGF that may show damage to the outer retina secondary to the severity and chronicity of the DME. Immunoreactive growth hormone in human peripheral T lymphocytes: encoding sequence of cDNA identical to that of the pituitary human growth hormone. However, the clinical significance, oncogenic functions and related mechanisms of CKS2 in colorectal cancer (CRC) remain largely unexplored. All women with available HPV genotyping results were included in the study. To measure the impact of race/ethnicity on cerclage efficacy, as measured by the prevalence of spontaneous preterm birth (PTB), in a cohort of patients with history-indicated, ultrasound-indicated and physical-exam indicated cerclages. Universal Theoretical Approach to Extract Anisotropic Spin Hamiltonians. Management of a perforated endotracheal tube during orthognathic surgery.

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SRs were counted between day 7 and day 10 and on day 14 of posthatch development, with samples at midlight, middark (14L:10D), and constant darkness. At the functional level, we observed significant increases in microbial features related to acetyl xylan esterase and pectinesterase for pericarp degradation during peeling. Sequencing of the D-loop fragment (819 bp) in 122 kaluga specimens collected in Lower Amur revealed 27 unique genotypes. This article presents the evaluation of the environmental effects of the SDM, including fugitive air emissions, leachate, and stormwater quality. Ethanol-induced increase in the metabolic clearance of 1,1,1-trichloroethane in human volunteers. Further, the impact of diffusion and mixing on the isotopic activity ratio lamivudine mg variability are explored. Losartan can alleviate experimental atherosclerosis induced by hyperuricemia.

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Australians are largely supportive of the provision of abortion and its decriminalization. The results suggest that Ginkgol C17:1 is a potent tumor inhibiting compound that acts on EGF-induced signal transduction of the PI3K/Akt signaling pathways, and may represent a clinically interesting candidate for cancer therapy. Here we describe a technique based on single molecule Fluorescence in-situ Hybridization (smFISH) to measure transcription and degradation rates in intact mammalian tissues. 5) The role of operative laparoscopy to perform infertility surgery. The effect of bradykinin on GnRH release is not mediated by the classical major transmitter, glutamate, as glutamate antagonists had no effect on bradykinin requip normal dose stimulation of GnRH release. Genetic, structural, and challenge studies revealed virus mutations and verified the infections.

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