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Alfresh (Alprazolam)

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Alfresh is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alfresh, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alfresh is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcalm, Alcicalm, Aldip, Almac, Alpose, Alprawin, Alprine, Alproz, Alzoact, Alzoset, Alzot, Alzotime, Ambusyn, Anxigon, Anxilam, Anxyl, Ateez, Azoslip, Benzax, Benzolam, Depser, Depten, Dipra, Finezol, Fluprax, Fluti, Fluwel, Isorest, Mebaspa, Niravam, Orten, Prozolam, Restyl, Rezolam, Rivcam, Trika, Zolax, Zolyde, Zopax, Zopic

Similar Products:
Motrin, Tofranil, Panadol, Revia, Levlen, Ditropan, Tensapril, Formador, Accrivir, Etrik, Krobicin, Nubrex, Azomycin,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Take Alfresh XR exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Alfresh XR may be habit-forming and should be used only by the person it was prescribed for. Alfresh XR should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not crush, chew, or break a Alfresh extended-release tablet. Swallow the tablet whole. It is specially made to release alprazolam slowly in the body. Breaking the tablet would cause too much alprazolam to be released at one time.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Your symptoms may return when you stop using Alfresh XR after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Alfresh XR.

Withdrawal symptoms may include blurred vision, trouble concentrating, loss of appetite, diarrhea, muscle twitching, numbness or tingling, or increased sensations.

Do not stop using Alfresh XR suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

Store Alfresh XR at room temperature away from moisture, heat, and light. Remove any cotton from the bottle of disintegrating tablets, and keep the bottle tightly closed.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Detailed Alfresh XR dosage information


If you have been prescribed Alfresh for medical reasons, the best way to avoid a Alfresh overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Alfresh consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alfresh XR dosage information

Side effects

The most common side effects associated with Alfresh are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Spasm of cerebral vessels following subarachnoid hemorrhage from the clinical and angiographic viewpoints. Localization of candidate regions for a novel gene for Kartagener syndrome. Cross-sectional, descriptive study of Chagas disease among citizens of Bolivian origin living in Munich, Germany. Relationships of miR-29a/b/c and CDC42 expressions to grade and survival-time in 147 human gliomas were analysed by in situ hybridisation and immunohistochemistry. These factors should be considered in the assessment of asphyxiation and choking risk and management. Finally, current approaches to allogeneic MSC application are discussed. In contrast, at lower temperatures and densities, where the particle-particle interaction dominates, the system behaves structurally and dynamically similar to a hard-core repulsive system.

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We analyzed the data of 589 kidneys used for kidney transplantation from 304 non-heart-beating donors from January 2002 through December 2013 at the Japan Organ Transplant Network West Japan Division. All these data are consistent with the observation that older genes bear relatively higher expression levels and suggest that the evolution of histone modifications could be implicated in transcriptional evolution after gene birth. The main inclusion criteria were randomized controlled trials or interventional studies on use of an injury prevention program that included the NH exercise while the primary outcome was hamstring injury rate. The purpose of our study was to implement AMESING MRSI of the liver at 3T and 7T, derive localized T2 information and compare T2-weighted average spectra in terms of SNR. Indirect sublingual lymphography in the maxillofacial and cervical regions. Discovery versus implementation research on mental disorders in low- and middle-income countries. Moreover, we have studied eight ionizable protein residues close to the active site with MD simulations and determined the most likely protonation states. Mucosal PGE2 decreased at the first week after vagotomy, however, reduced PGE2 recovered up-to the level with non-vagotomized dogs at the second week after thoracic truncal vagotomy and at the third week after abdominal truncal vagotomy, respectively. Results from these analyses suggest that veterans possibly exposed at Khamisiyah experienced different patterns of brain cancer mortality risk compared to the other groups.

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Data were also collected on 2 control groups: 100 pregnant women with normal glucose challenge test results (group B) and all 76 pregnant women who were diagnosed with gestational diabetes mellitus during this period of time (group C). Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials. The patient was discharged on post-operative day 13 following an uneventful recovery. In Study 2, 68 undergraduates were provided positive or negative feedback. These findings indicate that maternal environmental effect should be considered into the model projection of vegetation dynamics in response to ongoing environmental change. Acupoint stimulation manipulation was used for channels and collaterals comprehensive systematic experiment for signing, and changes of voice quality before and after stimulation of acupoints were investigated. The present study has investigated the effects of the main electrospinning parameters on tensile and suture retention strength of polycaprolactone (PCL) scaffolds using response surface methodology. Three new cases compatible with hypnic headache syndrome (HHS) are presented. Toward a zero VAP rate: personal and team approaches in the ICU.

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After ventriculoperitoneal shunt placement, the blood glucose and serum somatomedin-C levels of the patient decreased toward normal. PRMTs are divided into three categories: type I PRMTs which catalyze mono- and asymmetric dimethylation of arginine residues, type II PRMTs which catalyze mono- and symmetric dimethylation of arginine residues, and type III PRMT which catalyzes only monomethylation of arginine residues. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Acute pancreatitis: A 7 year retrospective cohort study of the epidemiology, aetiology and outcome from a tertiary hospital in Jamaica. The initial amount of food eaten each day was positively correlated with weight gain for control birds, but negatively correlated for lead-treated birds. In contrast, the intrauterine pressure values induced by prostaglandin F2 alpha given IV during early and late diestrus were 61 and 58 mm of Hg, respectively, and for oxytocin, were 61 and 51 mm of Hg, respectively. The aim of this article is to review the antimicrobial potential of essential oils secreted from MAPs and their possible mechanisms of action against human pathogens. Neuroendocrine tumours (NET) are rare neoplasms, but the incidence is permanently increasing. Effects of antisense oligodeoxynucleotides to NR1 on suppression of seizures and protection of cortical neurons from excitotoxicity in vivo and in vitro.

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This article reviews controversies surrounding monotherapy studies and the design of comparative monotherapy clinical trials. To report a probable anaphylactoid reaction to pentastarch, a low molecular weight hydroxyethyl starch (HES) colloid solution. The correlation between these levels and the maturity of the oocyte, judged from the morphology of the oocyte corona cumulus complex (OCCC) and the fertilizability of the oocytes was analysed. Reproductive risk factors such as preeclampsia and recurrent miscarriages have been associated with adverse cardiovascular (CV) events. A systematic literature review and a network meta-analysis were conducted to estimate ACR responses to ETN and LFN. CK may be useful in predicting epithelial differentiation and Ki-67 and p53 act as weak indicators of malignant disease progression in oral tissues. When two adenosine uptake inhibitors, dipyridamole and papaverine were injected intravitreally, the ocular blood flow increased in all ocular tissues tested: iris, iris root-ciliary body, retina and choroid. There is little to distinguish thermotolerance in normal and neoplastic cells when compared on an equal basis as demonstrated here, indicating that therapeutic gain in vivo may be largely dependent on tumour physiology.

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The pesticide DDT possesses structural characteristics that would permit it to participate in several types of molecular association. Next-generation sequencing (NGS) approaches are commonly used to identify key regulatory networks that drive transcriptional programs. Current status and future direction in the management of malignant melanoma. Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism. Familiarity strength was, therefore, judged as absent (misses) or present at three levels of increasing strength. Radiation-triggered Sp1 overexpression was responsible for radioresistance of OSCC (oral squamous cell carcinoma) cells. CT imaging of the adrenals confirmed hyperplasia, and ultrasound of the testes confirmed Testicular Adrenal Rest tumour, a rare finding. This clinical report illustrates a multidisciplinary approach for the rehabilitation of a young adult patient affected by a bilateral edentulous space and an anterior deep bite. Hepatic lesions were diagnosed concurrently with the primary lesions in 45 of the 67 patients in the S group. Decidual cell suspensions did not appear to contain significant numbers of functional B or T effector cells.

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The presence of the antiphospholipid antibodies may increase the risk of massive adrenal hemorrhage, particularly in patients who receive anticoagulant drugs. Oxygen and Light Induced Oxidations of Cytochrome, Flavoprotein, and Pyridine Nucleotide in a Chlamydomonas Mutant. In contrast, tolbutamide injections elicited an immediate 3-4-fold increase in fetal plasma insulin concentrations. MCL is positive for CD5, CD19, CD20, CD22, CD79b, kappa, and negative for CD23, CD43, and CD200. In situ synthesis of electroactive conjugated microporous fullerene films capable of supercapacitive energy storage. Electrospun metal-organic framework derived hierarchical carbon nanofibers with high performance for supercapacitors. The aim of this study was to investigate the effect of short-term use of taurolidine on the liver.

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The area under curve produced using the compound statistical model could more accurately discriminate anti what is the drug imuran used to treat -VEGF-treated tumors from untreated tumors than conventional contrast-enhanced ultrasound image processing. Our purpose was to determine the relative accuracy of indicated versus screening second-trimester ultrasonography for detection of fetal anomalies and to assess the cost effectiveness of anomaly screening. Inside the brain: revolutionary discoveries of how the mind works. All dung beetle functional groups had a clear preference for fresh dung. This needs assessment can serve to inform the development of a universal intern curriculum targeting the millennial generation. In such delay systems, noise can give rise to undesirable oscillations at frequencies resonant to the delay times. Long-Term Stability and Clinical Utility of Amplified Atrial Electrograms in a Single-Lead ICD System with Floating Atrial Electrodes. Amblyopic children read more slowly and had more saccades compared with nonamblyopic children with treated strabismus and normal controls. Comparison of rats of the Fischer 344 and Long-Evans strains in their autonomic thermoregulatory response to trimethyltin administration.

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These parameters were used to test for associations between anatomic complexity and SF rates. A viscoelastic material model is assumed for the macromechanical response of the tissue. In both models, we calculated the equilibrium carriage prevalence to predict the impact of control measures (reducing contact and decolonization). No fibers corresponding to the dopaminergic olivocochlear lateral efferent system of guinea pig were found in ISB and TSB within the OC in chinchilla. The 40 patients in the experimental group suffered from subclinical chorioamnionitis, while the 40 patients in the control singulair 10 mg age group exhibited no lesions of the placenta or fetal membrane.

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A model for the behavior of vesicles in density gradients: implications for fractionation. The patients with multiple sclerosis performed significantly worse than controls on most tests of attention and memory during acute relapse and in remission. The beneficial effects of treatment to the majority of patients have been significant. The inhibition of glial cells activity by lidocaine, completely abolished the above-described effects. breviceps from the Mpumalanga Province (Clade 2) were retrieved as sister to A. Additional information on hearing level was obtained by the equivalent hearing loss (EHL) principle and on the visual deterioration by the functional vision score (FVS). Is There a Role for Internal Bracing and Repair of the Anterior Cruciate Ligament?. QOL is a critical element for older adults, and thus, further studies are warranted to assess whether peripheral arterial disease-specific management can improve QOL in older populations. A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Minimally invasive mitral valve repair as a routine approach in selected patients.

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Pacing Strategies and Metabolic Responses During 4-Minute Running Time-Trials. These data suggest a developmental trend of increasing length with age. Failure of brocresine (NSD 1055)--a histidine decarboxylase inhibitor--to influence skin histamine in mice. Contraceptive knowledge, attitudes and behaviors of black adolescent males attending a predominantly black university. Kate had recovered physically but knew she was not ready to take on full-time hours. Large B cell fractions stimulated high MLR to Mls and H-2 determinants, irrespective of whether the stimulators were exposed to irradiation or pretreated with mitomycin C. P-glycoprotein plays an important role in controlling the passage of substances between the blood and brain.

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These changes are interpreted as being due to replacement of the proximal histidine ligand under continuous illumination. Term Familiarity to indicate Perceived and Actual Difficulty of Text in Medical Digital Libraries. Impulsivity serves as an indicator of elevated ADHD symptoms across development periods in boys with FXS, while activity level is just indicative of higher ADHD scores at the preschool age. Radiological resources excluded CT were higher degree of concentration than population distribution, and it showed that they were located relatively more intensively in urban areas than in rural areas. This stimulatory effect of IL-1 was completely inhibited by the addition of IL-1 receptor antagonist (IL-1ra). vasotec 5 mg oral tablet Our results indicate that the complexity of TBI outcomes is due in part to distinct, genetically controlled, age- and diet-regulated mechanisms that promote secondary injuries and that involve a subset of innate immune response genes. Stable transfection of NISH cells with BLG/Human Serum Albumin (HSA) hybrid gene constructs revealed that the relative level of expression was comparable to the in vivo secretion of HSA in transgenic mice carrying these gene sequences. The former was developed using a Scoring Matrix method and the latter based on the Support Vector Machine model. Thus, a change in NF gene expression may be an important component of an effective regenerative response and a critical step at which axonal caliber is regulated in injured neurons. A microstructural investigation of the damage behavior is performed using scanning electron microscopy.

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But, there exists an age-dependent influence on stroke of which the few existing experimental data are complex: the immature brain is, in fact, less resistant to hypoxic-ischemic brain damage than its adult counterpart. Child resistant packaging should be used on all over the counter drugs. Deriving freshwater safety thresholds for hexabromocyclododecane and comparison of toxicity of brominated flame retardants. Pulmonary function as a phenotype physiologic marker of cardiovascular morbidity and mortality. The data suggest that our therapeutic interventions may have influenced seizure frequency in at most a minority of cases. Currently, in the United States (and worldwide), the vast majority of individuals in need of mental health services receive no treatment. In orthopedic practice, it is one of the diseases that are causing implantation of hip replacement at a relatively early age. Many plant cells can be reprogrammed into a pluripotent state that allows ectopic organ development. However, expression of transgenes integrated into the nuclear genome of Chlamydomonas is very poor, probably because of severe transcriptional silencing irrespective of the genomic position. To study the effects of triptolide, a Chinese herb extract, on retinal ganglion cells (RGCs) in a rat model of chronic glaucoma.

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Statins are associated with lower risk of gastrointestinal bleeding in patients with unstable coronary syndromes: analysis of the Orbofiban in Patients with Unstable coronary Syndromes-Thrombolysis In Myocardial Infarction 16 (OPUS-TIMI 16) trial. Recent reports indicate that Vanabin2 binds twenty V(IV) ions at pH 7.5, and that it has a novel bow-shaped conformation. Contrary to naive expectations based on macroscopic magnetometry, our measurements reveal a superparamagnetic state formed by weakly interacting magnetic domains with a characteristic size of a few tens of nanometers. Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins. We compared the activity of BMP-7 with that of BMP-2 on nucleus pulposus (NP) arava classification of drug cell phenotype and function, and investigated how they differentially affect the gene expression profiles of signaling cascade components in human NP cells under degenerative states. We developed a bFGF fusion protein containing the PKD and the CBD of C histolyticum collagenase (bFGF-PKD-CBD), which markedly enhanced bone formation at a relatively low concentration when applied to the surface of rat femurs in a previous study. Theta frequency increased during apnea, prior to return of breathing.

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Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. Postoperative evaluation was performed by an independent observer. Local recurrence and late toxicity rates from 2005 through the end of 2014 are reported. Rate constants for the reactions of CO(3) (-) and O(3) (-) with SO(2) have can you drink alcohol while on roxithromycin been measured between 300 and 1440 K in a high temperature flowing afterglow apparatus. Secondary AG-IOL implantation in 35 eyes including 28 with traumatic cataract and 7 with senile cataract was performed 3 months to 2.5 years after primary cataract extraction. Our results support the notion that despite their extensive sequence variations, all functionally critical amino acid residues and motifs of the intercellular domain of Crb proteins are fully conserved between Drosophila and C. The Role of More Sensitive Helminth Diagnostics in Mass Drug Administration Campaigns: Elimination and Health Impacts.

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Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. The image acquisition time was 120 seconds and the radiation dose approximately one-tenth of a conventional CT scan. To assess the effect of ISDN on ventricular remodeling, 30 SD rats were randomized to three groups: Sham surgery, MI-NS (intratracheal NS 3 ml/kg for 13 days following coronary ligation), and MI-ISDN (intratracheal ISDN 3 mg/kg for 13 days following coronary ligation). Further studies are needed to develop criteria for more selective use of ADM in these patients. To compare sensitivity and specificity of functional and structural changes in glaucoma using two objective tests: the multifocal visual evoked potential (m-VEP) and Heidelberg retinal tomography II (HRT). This phenomenon was histologically demonstrated in our patient, and it may be suggested that its strong enhancement by the antifibrinolytic agent had resulted in the fatal accident. The fate of exogenous materials placed in the middle ear and frontal sinus of cats. The proposed technique has a potential for the future development of inexpensive and environmentally friendly technologies for the production of new pharmaceutical plant-based substances.

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To determine whether the antiapoptotic effect of parkin involves changes in gene expression, we used Affymetrix oligonucleotide microarrays to analyse gene expression in stably transfected PC12 cells which conditionally overexpress parkin, that were treated or not with C2-ceramide. In addition, NCE did not create a clinically significant change in the occlusion effect for bone-conduction testing. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. We examine this phenomenon from a theoretical standpoint using a mathematical model for sequential-step immunoassays in the presence of interferent. This study reviews UK Intensive Care admissions for children with cancer and VCP using data obtained from the Pediatric Intensive Care Audit Network (PICANet) database. The hemoglobin solution was produced by physical hemolysis of human erythrocytes followed by ultracentrifugation and filtration. Entamoeba histolytica: inflammatory process during amoebic liver abscess formation involves cyclooxygenase-2 expression in macrophages and trophozoites.

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However, the degree of trimerization of light-harvesting complex II and the photosynthetic quantum yield of transformed dgd1 plants were only partially restored. Antibody responses to tetanus toxoid (TT), measles vaccines, and environmental antigens amiodarone dose ventricular fibrillation (total IgG levels) were measured in 210 Gambian twin pairs recruited at birth. Further experiments were performed with 0.5 mM L-arginine plus 100 mM or 1000 mM of the NO synthase (NOS) inhibitor NG-nitro-L-arginine methylester (L-NAME) to determine whether or not the effects of L-arginine are mediated through the NO pathway. It is accepted that persons with autism react in an inappropriate way to socially relevant information and that they are unable to benefit from important stimuli from their surroundings. Here, we provide an overview of a selection of their equilibrium and dynamical properties. Fifteen laminin isoforms exist, assembled from various combinations of 5alpha, 3beta, and 3gamma chains. Disorders of brain energy metabolism and neurotransmitter recycling have been implicated in multiple neurological conditions.

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