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Alfatrim (Trimethoprim)

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Alfatrim is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Sulfamethoxazole is an anti-bacterial sulfonamide, a sulfa drug.

Other names for this medication:
Bacterol, Bactramin, Bactrizol, Bioprim, Bismoral, Chemitrim, Cotribene, Cotrix, Diseptyl, Ectaprim, Editrim, Erphatrim, Escoprim, Globaxol, Groseptol, Ifitrim, Ikaprim, Infectrin, Kaftrim, Kepinol, Linaris, Meprim, Metoxiprim, Momentol, Netocur, Politrim, Primadex, Septra, Septrin, Servitrim, Sigaprim, Spectrem, Sulfamethoxazole, Sulfamethoxazolum, Sulfatrim, Sulfoprima, Sultrim, Sutrim, Tabrol, Theraprim, Trimecor, Trimethoprim, Trimoxsul, Trisulf, Zaxol

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Also known as: Trimethoprim


This medication is used to treat a wide variety of bacterial infections. It is also used to treat a certain type of pneumonia (pneumocystis pneumonia) in patients with a weakened immune system. This medication is a combination of 2 antibiotics: sulfamethoxazole and trimethoprim. It works by stopping the growth of bacteria and the pneumocystis fungus.


Adults: The usual adult dosage in the treatment of urinary tract infections is 1 Alfatrim DS (double strength) tablet or 2 Alfatrim tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.


Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.


Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfatrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Alfatrim is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency.

Alfatrim is contraindicated in pediatric patients less than 2 months of age. Alfatrim is also contraindicated in patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.

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