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Actizide

Actizide is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself in type 1 diabetes. It is taken by mouth. Effects generally begin within half an hour and can last for up to a day.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glimet, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

Actizide is a medication consists in a class of drugs called sulfonylureas. Actizide is used to treat type 2 diabetes. Actizide may be used along with diet, exercise and insulin therapy. Actizide is also known as Glipizide, Glytop SR. Actizide works by controlling blood sugar levels in your organism. Generic name of Actizide is Glipizide. Brand names of Actizide are Actizide, Actizide XL.

Dosage

Usual Adult Dose of Actizide for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Actizide XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Actizide XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Actizide for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Actizide dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Actizide XL dosage information

Side effects

The most common side effects associated with Actizide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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To evaluate the effect of spironolactone, a mineralocorticoid receptor antagonist, for nonresolving central serous chorioretinopathy. Viable HCMV in leukocytes (WBC) was detected by shell vial and tube culture methods. NPV was higher in CMP than in NP (p-value 0.024) and EP (p-value 0.002). Interleukin-6 produced by pancreatic carcinoma cells enhances humoral immune responses against tumor cells: a possible event in tumor regression. This amount closely corresponds to a monolayer composed of densely packed globular avidin molecules.

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Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion. Colleagues inclined to do research in correctional facilities can make significant contributions to nursing literature. A transverse loop colostomy to protect a low colorectal anastomosis should be carried out with minimal morbidity and mortality related to its creation and closure. A retrospective review of hospital records of a random sample of children receiving dental treatment under general anaesthesia during the years 1984 and 1996. From the deduced amino acid sequence, it was indicated to be a secreted glycoprotein with a characteristic ZP domain in the C-terminal half of the molecule.

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Connecting the macroscopic world of continuous fields to the microscopic world of discrete molecular events is important for understanding several phenomena occurring at physical boundaries of systems. Validation of vibration testing for the assessment of the mechanical properties of human lumbar motion segments. A measurement approach based on body-fixed sensors apparently may provide sensitive markers that can be used for clinical assessment and for enhancing rehabilitation targeting in post-stroke patients. Endothelin stimulation of ETA and ETB receptors results in different and often opposing effects, which under physiologic conditions, establishes a balance that contributes to the regulation of vascular tone and blood pressure. Based on this assumption we carried out a case control study to determine the association of PTb with the HLA-DR and-DQ antigens among a sample of patients attending a medical unit belonging to the Mexican Social Security System (IMSS). For instance, it is unclear whether prodromal symptoms are useful for predicting relapse. Search for acid-alcohol resistant bacilli in 1222 pathological specimens.

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The AvrBs3 protein of the phytopathogenic bacterium Xanthomonas campestris pv. A unique digital microfluidic electroporation (EP) system successfully demonstrates higher transgene expression than that of conventional techniques, in addition to reliable productivity and feasible integrated processes. Diabetic patients had a longer delay in access to health care, though such delay was not independently related to increased mortality. Rationale for accuracy and consistency in applying standardized definitions for surveillance of health care-associated infections. Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells. Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate. Cumulative gene and chromosome alterations associated with in-vitro neoplastic transformation of human cervical cells. The essence of SSVEP recognition is to recognize the frequency component of target stimulus focused by a subject significantly present in EEG spectrum.

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